{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:00:46Z","timestamp":1787900446382,"version":"build-2784847793"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to evaluate the efficacy of Pycnogenol (PYC) and its antioxidant and antiapoptotic effect in an experimental hypoxic\u2013ischemic (HI) rat model.<\/jats:p><jats:p>\n            Study Design\u2003A total of 24 Wistar albino rats who were on the seventh postnatal day were divided into three groups with developed HI brain injury model under the sevoflurane anesthesia: 40\u2009mg\/kg PYC was given to Group A, saline was given to Group B, and the sham group was Group C. Neuronal apoptosis was investigated by terminal deoxynucleotidyl transferase dUTP nick end labeling and immunohistochemically stained manually with primer antibodies of tumor necrosis factor-\u03b1 and interleukin-1\u03b2.<\/jats:p><jats:p>\n            Results\u2003The neuronal cell injury was statistically lower in the PYC treatment group.<\/jats:p><jats:p>\n            Conclusion\u2003This is the first study that investigates the role of PYC in the HI brain injury model. PYC reduces apoptosis and neuronal injury in the cerebral tissue of the rats. PYC may be a protective agent against hypoxic\u2013ischemic encephalopathy.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1730349","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:27:52Z","timestamp":1622161672000},"page":"612-618","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Neuroprotective Effect of Pycnogenol in a Hypoxic\u2013Ischemic Brain Injury Model in Newborn Rats"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8732-7932","authenticated-orcid":false,"given":"Ruya","family":"\u00c7olak","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Division of Pediatric, Medical Park Bahcelievler Hospital, Alt\u0131nbas University Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-6080","authenticated-orcid":false,"given":"Asl\u0131","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, Faculty of Health Sciences, Dokuz Eyl\u00fcl University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-7584","authenticated-orcid":false,"given":"Gulden","family":"Diniz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical Faculty, Izmir Democracy University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-7120","authenticated-orcid":false,"given":"Senem","family":"Alkan \u00d6zdemir","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Dr. Beh\u00e7et Uz Children's Education and Research Hospital, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7817-7576","authenticated-orcid":false,"given":"Osman","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, Faculty of Health Sciences, Dokuz Eyl\u00fcl University, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-2690","authenticated-orcid":false,"given":"Sebnem","family":"Calkavur","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Dr. Beh\u00e7et Uz Children's Education and Research Hospital, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"ref1","first-page":"36","article-title":"Encefalopat\u00eda hip\u00f3xica-isqu\u00e9mica neonatal","volume":"78","author":"O Papazian","year":"2018","journal-title":"Medicina (B 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