{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:29:47Z","timestamp":1789777787274,"version":"4.0.1"},"reference-count":42,"publisher":"American Academy of Audiology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j am acad audiol"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p><jats:bold>Abstract<\/jats:bold>  <jats:bold>Background<\/jats:bold>\u2003Neurological, structural, and behavioral abnormalities are widely reported in individuals with autism spectrum disorder (ASD); yet there are no objective markers to date. We postulated that by using dominant and nondominant ear data, underlying\n differences in auditory evoked potentials (AEPs) between ASD and control groups can be recognized. <jats:bold>Purpose<\/jats:bold>\u2003The primary purpose was to identify if significant differences exist in AEPs recorded from dominant and nondominant ear stimulation in (1) children with ASD and their\n matched controls, (2) adults with ASD and their matched controls, and (3) a combined child and adult ASD group and control group. The secondary purpose was to explore the association between the significant findings of this study with those obtained in our previous study that evaluated the\n effects of auditory training on AEPs in individuals with ASD. <jats:bold>Research Design<\/jats:bold>\u2003Factorial analysis of variance with interaction was performed. <jats:bold>Study Sample<\/jats:bold>\u2003Forty subjects with normal hearing between the ages of 9 and 25 years were included. Eleven children and\n 9 adults with ASD were age- and gender-matched with neurotypical peers. <jats:bold>Data Collection and Analysis<\/jats:bold>\u2003Auditory brainstem responses (ABRs) and auditory late responses (ALRs) were recorded. Adult and child ASD subjects were compared with non-ASD adult and child control subjects,\n respectively. The combined child and adult ASD group was compared with the combined child and adult control group. <jats:bold>Results<\/jats:bold>\u2003No significant differences in ABR latency or amplitude were observed between ASD and control groups. ALR N1 amplitude in the dominant ear was significantly\n smaller for the ASD adult group compared with their control group. Combined child and adult data showed significantly smaller amplitude for ALR N1 and longer ALR P2 latency in the dominant ear for the ASD group compared with the control group. In our earlier study, the top predictor of behavioral\n improvement following auditory training was ALR N1 amplitude in the dominant ear. Correspondingly, the ALR N1 amplitude in the dominant ear yielded group differences in the current study. <jats:bold>Conclusions<\/jats:bold>\u2003ALR peak N1 amplitude is proposed as the most feasible AEP marker in the evaluation\n of ASD.<\/jats:p>","DOI":"10.1055\/s-0041-1730365","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T23:54:03Z","timestamp":1635983643000},"page":"379-385","source":"Crossref","is-referenced-by-count":3,"title":["Characteristic Deviations of Auditory Evoked Potentials in Individuals with Autism Spectrum Disorder"],"prefix":"10.3766","volume":"32","author":[{"given":"Kamakshi V.","family":"Gopal","sequence":"first","affiliation":[{"name":"Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C.","family":"Schafer","sequence":"additional","affiliation":[{"name":"Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Nandy","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, University of North Texas Health Science Center, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Department of Audiology and Speech-Language Pathology, University of North Texas, Denton, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Audiology and Speech-Language Pathology, University of North Texas, 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children at risk for central auditory processing disorders","volume":"28","author":"K V Gopal","year":"1999","journal-title":"Scand Audiol"},{"key":"ref4","volume-title":"SCAN: A Screening Test for Auditory Processing Disorders","author":"R W Keith","year":"1986"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrneurol.2017.15","article-title":"Translational use of event-related potentials to assess circuit integrity in ASD","volume":"13","author":"M E Modi","year":"2017","journal-title":"Nat Rev Neurol"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0165-1781(80)90052-9","article-title":"An electrophysiologic indication of auditory processing defects in autism","volume":"3","author":"B Novick","year":"1980","journal-title":"Psychiatry Res"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/WNN.0000000000000154","article-title":"Auditory brainstem pathology in autism spectrum disorder: a review","volume":"31","author":"J P Pillion","year":"2018","journal-title":"Cogn Behav Neurol"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/aur.1946","article-title":"Click-evoked auditory brainstem responses and autism spectrum disorder: a meta-analytic review","volume":"11","author":"N M Talge","year":"2018","journal-title":"Autism Res"},{"issue":"07","key":"ref9","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.clinph.2018.04.599","article-title":"Role of inter-trial phase coherence in atypical auditory evoked potentials to speech and nonspeech stimuli in children with autism","volume":"129","author":"L Yu","year":"2018","journal-title":"Clin Neurophysiol"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.ijporl.2014.10.039","article-title":"The correlation between central auditory processing in autistic children and their language processing abilities","volume":"78","author":"H G Azouz","year":"2014","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/aur.1561","article-title":"Prolonged auditory brainstem responses in infants with autism","volume":"9","author":"O Miron","year":"2016","journal-title":"Autism Res"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1469-8749.2011.04149.x","article-title":"Evidence for atypical auditory brainstem responses in young children with suspected autism spectrum disorders","volume":"54","author":"D A Roth","year":"2012","journal-title":"Dev Med Child Neurol"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF02207329","article-title":"Brainstem auditory evoked potential study in children with autistic disorder","volume":"21","author":"V Wong","year":"1991","journal-title":"J Autism Dev Disord"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF01837899","article-title":"Event-related brain potential correlates of the processing of novel visual and auditory information in autism","volume":"15","author":"E Courchesne","year":"1985","journal-title":"J Autism Dev Disord"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/aur.1495","article-title":"Audiometric profiles in autism spectrum disorders: does subclinical hearing loss impact communication?","volume":"9","author":"C Demopoulos","year":"2016","journal-title":"Autism Res"},{"issue":"02","key":"ref16","first-page":"21","article-title":"Brainstem auditory evoked potentials in boys with autism: still searching for the hidden truth","volume":"9","author":"A Ververi","year":"2015","journal-title":"Iran J Child Neurol"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02408559","article-title":"A comparison of autistic syndromes with and without associated neurological problems","volume":"14","author":"B Garreau","year":"1984","journal-title":"J Autism Dev Disord"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1176\/ajp.147.12.1609","article-title":"Brainstem auditory evoked response and subcortical abnormalities in autism","volume":"147","author":"J Thivierge","year":"1990","journal-title":"Am J Psychiatry"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3109\/14992020903289790","article-title":"The effect of rate stress on the auditory brainstem response in autism: a preliminary report","volume":"49","author":"S Fujikawa-Brooks","year":"2010","journal-title":"Int J Audiol"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/aur.1886","article-title":"Auditory brainstem response in infants and children with autism spectrum disorder: a meta-analysis of wave V","volume":"11","author":"O Miron","year":"2018","journal-title":"Autism Res"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bandl.2012.04.007","article-title":"The effect of gender on the N1-P2 auditory complex while listening and speaking with altered auditory feedback","volume":"122","author":"S Swink","year":"2012","journal-title":"Brain Lang"},{"issue":"07","key":"ref22","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1044\/2017_JSLHR-H-16-0056","article-title":"Stability of the cortical sensory waveforms, the P1-N1-P2 complex and T-complex, of auditory evoked potentials","volume":"60","author":"M Wagner","year":"2017","journal-title":"J Speech Lang Hear Res"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10803-008-0652-9","article-title":"Event related potentials in the understanding of autism spectrum disorders: an analytical review","volume":"39","author":"S S Jeste","year":"2009","journal-title":"J Autism Dev Disord"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"48R","DOI":"10.1203\/PDR.0b013e3182130c54","article-title":"Sensory processing in autism: a review of neurophysiologic findings","volume":"69","author":"E J Marco","year":"2011","journal-title":"Pediatr Res"},{"issue":"08","key":"ref25","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s10803-009-0737-0","article-title":"Effects of background noise on cortical encoding of speech in autism spectrum disorders","volume":"39","author":"N Russo","year":"2009","journal-title":"J Autism Dev Disord"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s10803-013-1948-y","article-title":"Attenuated auditory event-related potentials and associations with atypical sensory response patterns in children with autism","volume":"45","author":"F CL Donkers","year":"2015","journal-title":"J Autism Dev Disord"},{"issue":"02","key":"ref27","first-page":"96","article-title":"Effects of auditory training on electrophysiological measures in individuals with autism spectrum disorder","volume":"31","author":"K V Gopal","year":"2020","journal-title":"J Am Acad Audiol"},{"key":"ref28","volume-title":"Comprehensive Test of Nonverbal Intelligence","author":"D D Hammill","year":"2009","edition":"2nd edition."},{"issue":"02","key":"ref29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/1469-8986.3720127","article-title":"Guidelines for using human event-related potentials to study cognition: recording standards and publication criteria","volume":"37","author":"T W Picton","year":"2000","journal-title":"Psychophysiology"},{"issue":"05","key":"ref30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3766\/jaaa.18062","article-title":"Effects of auditory training and remote microphone technology on the behavioral performance of children and young adults who have autism spectrum disorder","volume":"30","author":"E C Schafer","year":"2019","journal-title":"J Am Acad Audiol"},{"issue":"07","key":"ref31","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3766\/jaaa.14096","article-title":"Age- and gender-specific normative information from children assessed with a dichotic words test","volume":"26","author":"D Moncrieff","year":"2015","journal-title":"J Am Acad Audiol"},{"issue":"01","key":"ref32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3766\/jaaa.20.1.6","article-title":"Recognition of randomly presented one-, two-, and three-pair dichotic digits by children and young adults","volume":"20","author":"D W Moncrieff","year":"2009","journal-title":"J Am Acad Audiol"},{"issue":"03","key":"ref33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijpsycho.2004.04.001","article-title":"Cortical auditory evoked potentials in autism: a review","volume":"53","author":"M D Bomba","year":"2004","journal-title":"Int J Psychophysiol"},{"issue":"04","key":"ref34","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3346\/jkms.2007.22.4.656","article-title":"Electrophysiologic assessment of central auditory processing by auditory brainstem responses in children with autism spectrum disorders","volume":"22","author":"S Kwon","year":"2007","journal-title":"J Korean Med Sci"},{"issue":"01","key":"ref35","first-page":"31","article-title":"Study of auditory evoked potentials in autism","volume":"22","author":"F CL Magliaro","year":"2010","journal-title":"Pro Fono"},{"issue":"04","key":"ref36","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/01.aud.0000224981.60575.d8","article-title":"Auditory characteristics of children with autism","volume":"27","author":"A M Tharpe","year":"2006","journal-title":"Ear Hear"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S1388-2457(99)00149-2","article-title":"Auditory associative cortex dysfunction in children with autism: evidence from late auditory evoked potentials (N1 wave-T complex)","volume":"110","author":"N Bruneau","year":"1999","journal-title":"Clin Neurophysiol"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10484-009-9074-5","article-title":"Event-related potential study of novelty processing abnormalities in autism","volume":"34","author":"E Sokhadze","year":"2009","journal-title":"Appl Psychophysiol Biofeedback"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0167-8760(88)90032-3","article-title":"Event-related potentials in autistic and healthy children on an auditory choice reaction time task","volume":"6","author":"R D Oades","year":"1988","journal-title":"Int J Psychophysiol"},{"issue":"07","key":"ref40","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.rasd.2013.03.007","article-title":"Early and late auditory event-related potentials in cognitively high functioning male adolescents with autism spectrum disorder","volume":"7","author":"S Andersson","year":"2013","journal-title":"Res Autism Spectr Disord"},{"issue":"03","key":"ref41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1207\/s15324826an0403_5","article-title":"Dichotic listening: elimination of the right ear advantage under a dual task procedure","volume":"4","author":"M Gadea","year":"1997","journal-title":"Appl 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