{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:50:21Z","timestamp":1758639021099,"version":"3.37.3"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81800581"],"award-info":[{"award-number":["81800581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Basic Research Program of Shaanxi","award":["2019JQ-952"],"award-info":[{"award-number":["2019JQ-952"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["xjj2018276"],"award-info":[{"award-number":["xjj2018276"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institutional Foundation of the University","award":["2019QN-17"],"award-info":[{"award-number":["2019QN-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Systemic inflammation contributes to cardiac surgery\u2013associated acute kidney injury (AKI). Cardiomyocytes and other organs experience hypothermia and hypoxia during cardiopulmonary bypass (CPB), which induces the secretion of cold-inducible RNA-binding protein (CIRP). Extracellular CIRP may induce a proinflammatory response.<\/jats:p><jats:p>\n          Materials and Methods\u2003The serum CIRP levels in 76 patients before and after cardiac surgery were determined to analyze the correlation between CIRP levels and CPB time. The risk factors for AKI after cardiac surgery and the in-hospital outcomes were also analyzed.<\/jats:p><jats:p>\n          Results\u2003The difference in the levels of CIRP (\u0394CIRP) after and before surgery in patients who experienced cardioplegic arrest (CA) was 26-fold higher than those who did not, and 2.7-fold of those who experienced CPB without CA. The \u0394CIRP levels were positively correlated with CPB time (r\u2009=\u20090.574, p\u2009&lt;\u20090.001) and cross-clamp time (r\u2009=\u20090.54, p\u2009&lt;\u20090.001). Multivariable analysis indicated that \u0394CIRP (odds ratio: 1.003; 95% confidence interval: 1.000\u20131.006; p\u2009=\u20090.027) was an independent risk factor for postoperative AKI. Patients who underwent aortic dissection surgery had higher levels of CIRP and higher incidence of AKI than other patients. The incidence of AKI and duration of mechanical ventilation in patients whose serum CIRP levels more than 405 pg\/mL were significantly higher than those less than 405 pg\/mL (65.8 vs. 42.1%, p\u2009=\u20090.038; 23.1\u2009\u00b1\u200918.2 vs. 13.8\u2009\u00b1\u20099.2\u2009hours, p\u2009=\u20090.007).<\/jats:p><jats:p>\n          Conclusion\u2003A large amount of CIRP was released during cardiac surgery. The secreted CIRP was associated with the increased risk of AKI after cardiac surgery.<\/jats:p>","DOI":"10.1055\/s-0041-1730450","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T22:55:43Z","timestamp":1625698543000},"page":"542-547","source":"Crossref","is-referenced-by-count":6,"title":["CIRP Secretion during Cardiopulmonary Bypass Is Associated with Increased Risk of Postoperative Acute Kidney Injury"],"prefix":"10.1055","volume":"69","author":[{"given":"Wenyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Blood Purification, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Operation and Anesthesia, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-0098","authenticated-orcid":false,"given":"Xinglong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(19)32563-2","article-title":"Acute kidney injury","volume":"394","author":"C 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