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Th17 cells differentiate from Th0 na\u00efve T-cells in response to transforming growth factor \u03b21 (TGF-\u03b21) and IL-6, the cytokines which also drive development of liver fibrosis, require activation of transcription factor retinoic acid receptor-related orphan nuclear receptor gamma t (ROR\u03b3t). IL-17A signals through the ubiquitously expressed receptor IL-17RA. Expression of IL-17RA is upregulated in patients with hepatitis B virus\/hepatitis C virus (HBV\/HCV) infections, nonalcoholic steatohepatitis (NASH), alcohol-associated liver disease (AALD), hepatocellular carcinoma (HCC), and experimental models of chronic toxic liver injury. The role of IL-17 signaling in the pathogenesis of NASH- and AALD-induced metabolic liver injury and HCC will be the focus of this review. The role of IL-17A\u2013IL-17RA axis in mediation of the cross-talk between metabolically injured hepatic macrophages, hepatocytes, and fibrogenic myofibroblasts will be discussed.<\/jats:p>","DOI":"10.1055\/s-0041-1730926","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T18:50:18Z","timestamp":1623783018000},"page":"507-515","source":"Crossref","is-referenced-by-count":60,"title":["Interleukin-17 in Liver Disease Pathogenesis"],"prefix":"10.1055","volume":"41","author":[{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai University of Medicine & Health Sciences, Shanghai, P.R. China"},{"name":"Department of Medicine, University of California, San Diego, La Jolla, CA"},{"name":"Department of Surgery, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego, La Jolla, CA"},{"name":"Department of Surgery, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Fuji","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Diego, La Jolla, CA"},{"name":"Department of Surgery, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kisseleva","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, San Diego, La Jolla, 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