{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:26:10Z","timestamp":1791822370970,"version":"4.3.4"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim\u2003The prevalence of congenital cerebral palsy (CP) worldwide ranges from 0.15 to 0.4%. CP causes several gastrointestinal complications that inhibit normal eating behavior. This single-center observational study aimed to determine the tolerability and benefits of percutaneous endoscopic gastrostomy (PEG) in pediatric CP patients with malnutrition.<\/jats:p><jats:p>\n          Materials and Methods\u2003The study included 41 pediatric CP patients with malnutrition. All patient data were retrospectively obtained from Bak\u0131rk\u00f6y Dr. Sadi Konuk Research and Training Hospital, Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Istanbul, Turkey. In addition to baseline measurements of weight, height, triceps skinfold thickness, 1,25-hydroxyvitamin D3, folate, iron, zinc, vitamin B12, hemoglobin, and mean corpuscular volume, data analyzed included follow-up measurements recorded at 3 and 6 months of PEG (standard polymeric enteral supplementation as 1.0 kcal mL\u20131).<\/jats:p><jats:p>\n          Results\u2003There was significant improvement in both height, weight, and triceps skinfold thickness in all patients at 3 and 6 months of PEG (p\u2009&lt;\u20090.05). In terms of blood parameters, there was not significant improvement, except that the number of patients with a low hemoglobin count significantly decreased at 3 and 6 months of (p\u2009=\u20090.022). Moreover, the number of patients with vomiting after PEG also significantly decreased at 3 and 6 months of (p\u2009=\u20090.004).<\/jats:p><jats:p>\n          Conclusion\u2003PEG significantly improves malnutrition in pediatric CP patients and does not cause any major complications. Based on these findings, we think PEG is a beneficial and cost-effective intervention with a high rate of tolerability in pediatric CP patients with malnutrition.<\/jats:p>","DOI":"10.1055\/s-0041-1731007","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T23:00:59Z","timestamp":1625094059000},"page":"326-332","source":"Crossref","is-referenced-by-count":7,"title":["Percutaneous Endoscopic Gastrostomy Feeding in Children with Cerebral Palsy"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-9722","authenticated-orcid":false,"given":"Hasret Ayyildiz","family":"Civan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Bak\u0131rk\u00f6y Dr. Sadi Konuk Research and Training Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-3964","authenticated-orcid":false,"given":"Gonca","family":"Bektas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Bak\u0131rk\u00f6y Dr. Sadi Konuk Research and Training Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-2737","authenticated-orcid":false,"given":"Ali Evrim","family":"Dogan","sequence":"additional","affiliation":[{"name":"Nutricia, Advanced Medical Nutrition, Medical Department, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0163-318X","authenticated-orcid":false,"given":"Fatih","family":"Ozdener","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Bahcesehir University, School of Medicine, Istanbul, 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Dev"},{"issue":"06","key":"ref8","first-page":"534","article-title":"Gastrostomy feeding in cerebral palsy: a systematic review","volume":"89","author":"G Sleigh","year":"2004","journal-title":"Arch Dis Child"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.7861\/clinmedicine.10-6-624","article-title":"Malnutrition: causes and consequences","volume":"10","author":"J Saunders","year":"2010","journal-title":"Clin Med (Lond)"},{"key":"ref11","first-page":"3","article-title":"Existence, causes and consequences of disease-related malnutrition in the hospital and the community, and clinical and financial benefits of nutritional intervention","volume":"18","author":"C Green","year":"1999","journal-title":"Clin Nutr"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.nut.2011.05.015","article-title":"Malnutrition as an independent predictor of clinical outcome in critically ill 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Metab"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4103\/ijri.IJRI_393_17","article-title":"Percutaneous gastrostomy placement by intervention radiology: techniques and outcome","volume":"28","author":"B Karthikumar","year":"2018","journal-title":"Indian J Radiol Imaging"},{"issue":"02","key":"ref29","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1469-8749.2011.04166.x","article-title":"Nutritional rehabilitation increases the resting energy expenditure of malnourished children with severe cerebral palsy","volume":"54","author":"F E Arrowsmith","year":"2012","journal-title":"Dev Med Child Neurol"},{"issue":"05","key":"ref30","first-page":"2062","article-title":"Energy expenditure in children with cerebral palsy and moderate \/ severe malnutrition during nutritional recovery","volume":"31","author":"A A Garc\u00eda-Contreras","year":"2015","journal-title":"Nutr 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