{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:25:22Z","timestamp":1784294722478,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"04","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glob Med Genet"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effects of environmental and genetic factors. Although various linkage and genome-wide association studies for mandibular prognathism have identified multiple strongly associated regions and genes, the causal genes and variants responsible for the deformity remained ambiguous.<\/jats:p><jats:p>\n          Aim\u2003This research work was aimed to study the association between polymorphism rs10850110 of the MYO1H gene and skeletal class-III malocclusion in our local population.<\/jats:p><jats:p>\n          Materials and Methods\u2003Thirty patients with skeletal class III due to mandibular prognathism in the study group and 30 patients with skeletal class I in the control group were selected for this study. These patients were from both sexes and above age 10 years. Based on the cephalometric values, patients were categorized into study and control groups. SNB (angle between sella, nasion and point B at nasion) greater than 82\u2009degrees with an ANB (angle between point A, nasion and point B at nasion) of less than 0\u2009degrees in the study group and ANB (angle between point A, nasion and point B at nasion) of 2 to 4\u2009degrees in the control group were categorized. The polymorphism (rs10850110) of the MYO1H gene was genotyped using polymerase chain reaction and restriction fragment length polymorphism. Associations were tested with SNP exact test using SNPstats software.<\/jats:p><jats:p>\n          Results\u2003The single-nucleotide polymorphism rs10850110 showed a statistically significant association with mandibular prognathism. The G allele of marker rs10850110 (5\u2032 of myosin1H - MYO1H) was overrepresented when compared with the \u201cA\u201d allele in mandibular prognathism cases (p\u2009&lt;\u20090.0001), and this was very significant.<\/jats:p><jats:p>\n          Conclusion\u2003These results suggest that the rs10850110 polymorphism of the MYO1H gene is associated with an increased risk for mandibular prognathism.<\/jats:p>","DOI":"10.1055\/s-0041-1731066","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T22:43:45Z","timestamp":1624661025000},"page":"156-161","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism"],"prefix":"10.1016","volume":"08","author":[{"given":"Anjana","family":"Atteeri","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Neela","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan Kumar","family":"Mamillapalli","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasu M.","family":"Sesham","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekanth","family":"Keesara","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udayini","family":"Monica","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasavi","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhangi","family":"Miryala","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Makthal","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/(SICI)1098-2353(1999)12:5<382::AID-CA9>3.0.CO;2-0","article-title":"Morphologic determinants in the etiology of class III malocclusions: a review","volume":"12","author":"G D Singh","year":"1999","journal-title":"Clin Anat"},{"key":"ref2","first-page":"505","article-title":"A survey of handicapping dentofacial anomalies among Chinese in Hong Kong","volume":"14","author":"W C Allwright","year":"1964","journal-title":"Int Dent J"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1177\/00220345650440053301","article-title":"Prevalence of Class 1, Class 2, and Class 3 malocclusions (Angle) in an urban population. 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