{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:56:19Z","timestamp":1759564579627},"reference-count":66,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sudden cardiac arrest (SCA) is one of the leading causes of mortality and morbidity in the United States, and survivors are frequently left with severe disability. Of the 10% successfully resuscitated from SCA, only around 10% of these live with a favorable neurologic outcome. Survivors of SCA commonly develop post\u2013cardiac arrest syndrome (PCAS). PCAS is composed of neurologic, myocardial, and systemic injury related to inadequate perfusion and ischemia\u2013reperfusion injury with free radical formation and an inflammatory cascade. While targeted temperature management is the cornerstone of therapy, other intensive care unit\u2013based management strategies include monitoring and treatment of seizures, cerebral edema, and increased intracranial pressure, as well as prevention of further neurologic injury. In this review, we discuss the scientific evidence, recent updates, future prospects, and knowledge gaps in the treatment of post\u2013cardiac arrest patients.<\/jats:p>","DOI":"10.1055\/s-0041-1731310","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T22:30:27Z","timestamp":1629412227000},"page":"388-397","source":"Crossref","is-referenced-by-count":4,"title":["Updates on the Management of Neurologic Complications of Post\u2013Cardiac Arrest Resuscitation"],"prefix":"10.1055","volume":"41","author":[{"given":"Yunis","family":"Mayasi","sequence":"additional","affiliation":[{"name":"Division of NeuroCritical Care, Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota-University of South Dakota Medical School, Sioux Falls, South Dakota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romergryko G.","family":"Geocadin","sequence":"additional","affiliation":[{"name":"Division of Neurosciences Critical Care, Neurology, Neurosurgery and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/jama.2019.1696","article-title":"In-hospital cardiac arrest: a review","volume":"321","author":"L W Andersen","year":"2019","journal-title":"JAMA"},{"issue":"24","key":"ref2","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1136\/heartjnl-2015-307450","article-title":"Post-resuscitation care following out-of-hospital and in-hospital cardiac arrest","volume":"101","author":"S Girotra","year":"2015","journal-title":"Heart"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-2006-948317","article-title":"Mechanisms of injury in hypoxic-ischemic encephalopathy: implications to therapy","volume":"26","author":"D M Greer","year":"2006","journal-title":"Semin Neurol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/01.STR.0000196957.55928.ab","article-title":"Time is brain--quantified","volume":"37","author":"J L Saver","year":"2006","journal-title":"Stroke"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1055\/s-0036-1597833","article-title":"The brain after cardiac arrest","volume":"37","author":"J Elmer","year":"2017","journal-title":"Semin Neurol"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0196-0644(00)82028-4","article-title":"Molecular mechanisms of ischemic neuronal injury","volume":"36","author":"R W Neumar","year":"2000","journal-title":"Ann Emerg Med"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/jnr.24033","article-title":"Cortical spreading depolarizations in the postresuscitation period in a cardiac arrest male rat model","volume":"95","author":"F B Hansen","year":"2017","journal-title":"J Neurosci Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainres.2007.06.070","article-title":"Cortical spreading depression releases ATP into the extracellular space and purinergic receptor activation contributes to the induction of ischemic tolerance","volume":"1168","author":"S C Schock","year":"2007","journal-title":"Brain Res"},{"issue":"05","key":"ref9","first-page":"362","article-title":"Post-cardiac arrest syndrome","volume":"76","author":"A Binks","year":"2010","journal-title":"Minerva Anestesiol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4266\/acc.2019.00654","article-title":"Management of post-cardiac arrest syndrome","volume":"34","author":"Y Kang","year":"2019","journal-title":"Acute Crit Care"},{"issue":"23","key":"ref11","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1161\/CIRCULATIONAHA.108.190652","article-title":"Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. 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