{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:46:01Z","timestamp":1792759561428,"version":"4.5.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Plantar fasciitis (PF) is a chronic degenerative condition causing marked thickening and fibrosis of the plantar fascia, and collagen necrosis, chondroid metaplasia and calcification. There is little convincing evidence in support of various approaches, including homeopathy, for treating PF. This study was undertaken to examine the efficacy of individualized homeopathic medicines (IHMs) compared with placebo in the treatment of PF.<\/jats:p><jats:p>\n          Methods\u2003A double-blind, randomized, placebo-controlled trial was conducted at the outpatient departments of Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, West Bengal, India. Patients were randomized to receive either IHMs or identical-looking placebo in the mutual context of conservative non-medicinal management. The Foot Function Index (FFI) questionnaire, as an outcome measure, was administered at baseline, and every month, up to 3 months. Group differences (unpaired t-tests) and effect sizes (Cohen's d) were calculated on an intention-to-treat sample. The sample was analyzed statistically after adjusting for baseline differences.<\/jats:p><jats:p>\n          Results\u2003The target sample size was 128; however, only 75 could be enrolled (IHMs: 37; Placebo: 38). Attrition rate was 9.3% (IHMs: 4, Placebo: 3). Differences between groups in total FFI% score favored IHMs against placebo at all the time points, with large effect sizes: month 1 (mean difference, \u221210.0; 95% confidence interval [CI], \u221215.7 to \u22124.2; p\u2009=\u20090.001; d\u2009=\u20090.8); month 2 (mean difference, \u221214.3; 95% CI, \u221220.4 to \u22128.2; p &lt;0.001; d\u2009=\u20091.1); and month 3 (mean difference, \u221223.3; 95% CI, \u221230.5 to \u221216.2; p &lt;0.001; d\u2009=\u20091.5). Similar significant results were also observed on three FFI sub-scales (pain%, disability%, and activity limitation%). Natrum muriaticum (n\u2009=\u200914; 18.7%) and Rhus toxicodendron and Ruta graveolens (n\u2009=\u200911 each; 14.7%) were the most frequently prescribed medicines. No harms, serious adverse events, or intercurrent illnesses were recorded in either of the groups.<\/jats:p><jats:p>\n          Conclusion\u2003IHMs acted significantly better than placebo in the treatment of PF; however, the trial being underpowered, the results should be interpreted as preliminary only. Independent replications are warranted.<\/jats:p><jats:p>\n          Trial registration\u2003CTRI\/2018\/10\/016014.<\/jats:p>","DOI":"10.1055\/s-0041-1731383","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T22:52:08Z","timestamp":1631055128000},"page":"022-030","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of Individualized Homeopathic Medicines in Plantar Fasciitis: Double-blind, Randomized, Placebo-Controlled Clinical Trial"],"prefix":"10.1055","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-1645","authenticated-orcid":false,"given":"Sana","family":"Shahid","sequence":"additional","affiliation":[{"name":"Department of Case Taking and Repertory, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhamoy","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardhendu Shekhar","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Case Taking and Repertory, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukdeb","family":"Maiti","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satarupa","family":"Sadhukhan","sequence":"additional","affiliation":[{"name":"Department of Organon of Medicine and Homoeopathic Philosophy, National Institute of Homoeopathy, Ministry of AYUSH, Govt. of India, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munmun","family":"Koley","sequence":"additional","affiliation":[{"name":"Department of Organon of Medicine and Homoeopathic Philosophy, State National Homoeopathic Medical College and Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhranil","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Case Taking and Repertory, D.N. De Homoeopathic Medical College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"ref3","volume-title":"Harrison's Principles of Internal Medicine","author":"D L Kasper","year":"2015","edition":"19th ed."},{"key":"ref4","volume-title":"How do you manage plantar fasciitis?","author":"J Ryan","year":"2007","edition":"2nd ed."},{"key":"ref5","volume-title":"Current Medical Diagnosis & Treatment 2012","author":"S J McPhee","year":"2012","edition":"51st ed."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"ITC 1-1","DOI":"10.7326\/0003-4819-156-1-201201030-01001","article-title":"Plantar fasciitis","volume":"156","author":"C Young","year":"2012","journal-title":"Ann Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1056\/NEJMcp032745","article-title":"Clinical practice. 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