{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:33:48Z","timestamp":1787452428085,"version":"build-2736575974"},"reference-count":24,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Pulmonary toxicity due to chemotherapeutic agents can occur with many established and new drugs. Strong clinical suspicion is important as the clinical presentation is usually with nonspecific symptoms like cough, dyspnea, fever, and pulmonary infiltrates. Timely discontinuation of the offending agent alone can improve the condition.<\/jats:p>\n                  <jats:p>Methods A prospective observational study on patients receiving chemotherapy at an 800-bedded tertiary care hospital was performed from 2014 to 2016. Consecutive patients on chemotherapy, presenting with nonresolving respiratory symptoms were evaluated with contrast-enhanced computerized tomography of chest, diffusion lung capacity for carbon monoxide (DLCO), fiberoptic bronchoscopy with lavage, and biopsy, after excluding all causes for pulmonary infections. Descriptive data has been depicted.<\/jats:p>\n                  <jats:p>Results A total of 18 patients were evaluated for persistent symptoms of dry cough, dyspnea, and fever among 624 who received chemotherapy during the study period. Ground-glass opacities on high-resolution CT was the most common imaging finding, others being patchy subpleural consolidation and pleural effusion. Lymphocyte-predominant bronchoalveolar lavage was detected in nine. Eight of the 15 patients who underwent DLCO, had abnormal results. Seven had significant histopathological findings on bronchoscopic lung biopsy, which revealed organizing pneumonia as the most common pattern. Paclitaxel, fluorouracil, gemcitabine, and tyrosine kinase inhibitors were the common culprit drugs. Discontinuation alone of the culprit drug was effective in 15 and 3 needed oral corticosteroids for relief of symptoms. None of the patients died due to the toxicity.<\/jats:p>\n                  <jats:p>Conclusion An incidence of 2.8% for chemotherapy-induced lung injury was seen in our observational study of 3 years, with parenchymal, interstitial, and pleural involvement due to various chemotherapeutic agents. Oral steroids maybe required in a subset of patients not responding to discontinuation of the culprit agent.<\/jats:p>","DOI":"10.1055\/s-0041-1731581","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T19:02:17Z","timestamp":1636657337000},"page":"255-260","source":"Crossref","is-referenced-by-count":10,"title":["Chemotherapy-Associated Pulmonary Toxicity\u2014Case Series from a Single Center"],"prefix":"10.25259","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-8346","authenticated-orcid":false,"given":"Tilak","family":"TVSVGK","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Armed Forces Medical College (AFMC), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Medicine, INHS Asvini, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department Medicine, Command Hospital Air Force (CHAF), Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Mutreja","sequence":"additional","affiliation":[{"name":"Department of Pathology, Armed Forces Medical College (AFMC), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Armed Forces Medical College (AFMC), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1378\/chest.07-0851","article-title":"Pulmonary complications of novel antineoplastic agents for solid tumors","volume":"133","author":"B Vahid","year":"2008","journal-title":"Chest"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/hon.2900060407","article-title":"Severe lung toxicity with a weekly low dose chemotherapy regimen in patients with non-Hodgkin\u2019s lymphoma","volume":"6","author":"M Quigley","year":"1988","journal-title":"Hematol Oncol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00001813-199801000-00005","article-title":"Mechanism of transient dyspnea induced by pegylated-liposomal doxorubicin (Doxil)","volume":"9","author":"K M Skubitz","year":"1998","journal-title":"Anticancer Drugs"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0272-5231(03)00123-0","article-title":"Chemotherapy-induced lung disease","volume":"25","author":"A H Limper","year":"2004","journal-title":"Clin Chest Med"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1365-2354.2005.00589.x","article-title":"Acute interstitial pneumonitis during chemotherapy for haematological malignancy","volume":"14","author":"K Nakase","year":"2005","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/1078155211429384","article-title":"Chemotherapy-induced infiltrative pneumonitis cases in breast cancer patients","volume":"18","author":"S Kim","year":"2012","journal-title":"J Oncol Pharm Pract"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ccm.2004.05.006","article-title":"Drug-induced and iatrogenic infiltrative lung disease","volume":"25","author":"P Camus","year":"2004","journal-title":"Clin Chest Med"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJM199008093230604","article-title":"Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood","volume":"323","author":"B R O\u2019Driscoll","year":"1990","journal-title":"N Engl J Med"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.5858\/2007-131-407-TBIITP","article-title":"Transbronchial biopsy interpretation in the patient with diffuse parenchymal lung disease","volume":"131","author":"K O Leslie","year":"2007","journal-title":"Arch Pathol Lab Med"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1053\/sroe.2002.0000","article-title":"Drug-induced lung injury","volume":"37","author":"J J Erasmus","year":"2002","journal-title":"Semin Roentgenol"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2214\/ajr.176.3.1760718","article-title":"Paclitaxel-induced hypersensitivity pneumonitis: radiographic and CT findings","volume":"176","author":"P Wong","year":"2001","journal-title":"AJR Am J Roentgenol"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000011873","article-title":"Paclitaxel-induced cell-mediated hypersensitivity pneumonitis. Diagnosis using leukocyte migration test, bronchoalveolar lavage and transbronchial lung biopsy","volume":"55","author":"K Fujimori","year":"1998","journal-title":"Oncology"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1177\/106002809703101205","article-title":"Paclitaxel-induced acute bilateral pneumonitis","volume":"31","author":"A Khan","year":"1997","journal-title":"Ann Pharmacother"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1378\/chest.110.1.289","article-title":"Pulmonary infiltrates following administration of paclitaxel","volume":"110","author":"R K Ramanathan","year":"1996","journal-title":"Chest"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/1060028014566446","article-title":"Characteristics of and risk factors for interstitial lung disease induced by chemotherapy for lung cancer","volume":"49","author":"T Sakurada","year":"2015","journal-title":"Ann Pharmacother"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1093\/annonc\/mdq061","article-title":"Clinical features of interstitial lung disease induced by standard chemotherapy (FOLFOX or FOLFIRI) for colorectal cancer","volume":"21","author":"T Shimura","year":"2010","journal-title":"Ann Oncol"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00280-009-1167-6","article-title":"Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma","volume":"65","author":"F H Galv\u00e3o","year":"2010","journal-title":"Cancer Chemother Pharmacol"},{"issue":"06","key":"ref18","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s10147-012-0494-5","article-title":"Current status of DILD in molecular targeted therapies","volume":"17","author":"Y Saito","year":"2012","journal-title":"Int J Clin Oncol"},{"issue":"06","key":"ref19","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1080\/10428190600555868","article-title":"Dasatinib-related alveolar pneumonia responsive to corticosteroids","volume":"47","author":"F Radaelli","year":"2006","journal-title":"Leuk Lymphoma"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3892\/etm.2014.1495","article-title":"Gefitinib-induced interstitial pneumonia: a case report and review of the literature","volume":"7","author":"C Luo","year":"2014","journal-title":"Exp Ther Med"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2302\/kjm.2011-0009-OA","article-title":"Gefitinib, but not erlotinib, is a possible inducer of Fra-1-mediated interstitial lung disease","volume":"61","author":"Y Takada","year":"2012","journal-title":"Keio J Med"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"760","DOI":"10.5414\/CP201759","article-title":"Successful treatment with erlotinib after gefitinib-induced interstitial lung disease: a case report and literature review","volume":"50","author":"Y Koma","year":"2012","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"07","key":"ref23","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/JTO.0b013e3181d89ac2","article-title":"Successful treatment with erlotinib after gefitinib-induced severe interstitial lung disease","volume":"5","author":"M Takeda","year":"2010","journal-title":"J Thorac Oncol"},{"issue":"01","key":"ref24","first-page":"36","article-title":"The role of transbronchial lung biopsy for the diagnosis of diffuse drug-induced lung disease: a case series of 44 patients","volume":"25","author":"M Romagnoli","year":"2008","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1731581.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:13:25Z","timestamp":1781176405000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/chemotherapy-associated-pulmonary-toxicity-case-series-from-a-single-center\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,11]]},"references-count":24,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,12,31]]},"published-print":{"date-parts":[[2021,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1731581","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,11]]}}}