{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:52:47Z","timestamp":1791337967218,"version":"4.3.1"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background\u2003Childhood stroke is rare and can predispose to post-stroke epilepsy. The purpose of this study was to evaluate long-term quality of life (QoL) in patients with childhood stroke, focusing on epileptic aspects.<\/jats:p><jats:p>Method\u2003This involves a retrospective study of 98 patients with childhood stroke (pre- and neonatal strokes excluded), who had been inpatients between 1986 and 2003 for early rehabilitation. Data were obtained via interviews using a standardized questionnaire: QoL evaluation with KINDL, functional outcome with Barthel Index, and motor handicaps-assessment with modified Rankin Score.<\/jats:p><jats:p>Results\u2003Forty-nine of 98 patients (31 males, mean follow-up 16 years, range 8\u201325 years) were included. Six patients passed away (three of sudden unexpected death in epilepsy). At least one epileptic seizure occurred in 27\/49 patients (occurrence: 2 days\u201313 years.; mean 3.3 years.). Epilepsy manifested in 19\/49 patients. No correlation was found between the development of epilepsy and the location or etiology of the stroke. The presence of functional independence was significantly higher in seizure-free patients and in patients without epilepsy. For the external assessment (filled in for the patient by the parent\/caregiver), there was no significant difference in QoL in patients with and without epilepsy; however, in the in-person KINDL questionnaire a significantly lower QoL was noted in epilepsy patients compared with patients without epilepsy.<\/jats:p><jats:p>Conclusion\u2003One important finding in our study is that in the long-term course 39% of patients developed epilepsy after a childhood stroke. It occurred as late as 13 years after the acute episode and affected the QoL especially in cognitively less handicapped patients.<\/jats:p>","DOI":"10.1055\/s-0041-1731805","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T13:54:43Z","timestamp":1626184483000},"page":"469-474","source":"Crossref","is-referenced-by-count":9,"title":["Childhood Stroke: Long-Term Outcomes and Health-Related Quality of Life with a Special Focus on the Development of Epilepsy"],"prefix":"10.1055","volume":"52","author":[{"given":"C.","family":"von St\u00fclpnagel","sequence":"additional","affiliation":[{"name":"Institute for Transition, Rehabilitation and Palliation, Paracelsus Private Medical University of Salzburg, Salzburg, Austria"},{"name":"Comprehensive Epilepsy Program for Children, Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, University Hospital Munich, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kutschker","sequence":"additional","affiliation":[{"name":"Office for General Medicine, Rott am Inn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Sperl","sequence":"additional","affiliation":[{"name":"University Hospital for Children and Adolescents, Landeskrankenhaus, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Berweck","sequence":"additional","affiliation":[{"name":"Institute for Transition, Rehabilitation and Palliation, Paracelsus Private Medical University of Salzburg, Salzburg, Austria"},{"name":"Center for Pediatric Neurology, Neurorehabilitation and Epileptology; Sch\u00f6n Clinic, Vogtareuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Staudt","sequence":"additional","affiliation":[{"name":"Center for Pediatric Neurology, Neurorehabilitation and Epileptology; Sch\u00f6n Clinic, Vogtareuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Berndt","sequence":"additional","affiliation":[{"name":"Institute for Medical Education, University Hospital, LMU Munich, Munich, Germany"},{"name":"Richard W. 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ed."},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1059131102001437","article-title":"Stroke and status epilepticus: stroke type, type of status epilepticus, and prognosis","volume":"12","author":"N Afsar","year":"2003","journal-title":"Seizure"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ana.25718","article-title":"Predicting recovery and outcome after pediatric stroke: results from the International Pediatric Stroke Study","volume":"87","author":"R J Felling","year":"2020","journal-title":"Ann Neurol"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejpn.2016.12.007","article-title":"Early seizures predict the development of epilepsy in children and adolescents with stroke","volume":"21","author":"I Breitweg","year":"2017","journal-title":"Eur J Paediatr Neurol"},{"key":"ref9","first-page":"56","article-title":"Functional evaluation: the Barthel index","volume":"14","author":"F I Mahoney","year":"1965","journal-title":"Maryland State Med J"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.STR.19.5.604","article-title":"Interobserver agreement for the assessment of handicap in stroke patients","volume":"19","author":"J C van Swieten","year":"1988","journal-title":"Stroke"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1023\/A:1008853819715","article-title":"Assessing health-related quality of life in chronically ill children with the German KINDL: first psychometric and content analytical results","volume":"7","author":"U Ravens-Sieberer","year":"1998","journal-title":"Qual Life Res"},{"key":"ref12","first-page":"653","article-title":"News from the KINDL-Questionnaire\u2014a new version for adolescents","volume":"7","author":"U Ravens-Sieberer","year":"1998","journal-title":"Qual Life Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1007\/s00103-007-0244-4","article-title":"Gesundheitsbezogene Lebensqualit\u00e4t von Kindern und Jugendlichen in Deutschland","volume":"50","author":"U Ravens-Sieberer","year":"2007","journal-title":"Bundesgesundheitsbl-Gesunheitsforsch-Gesundheitsschutz"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jpeds.2011.07.048","article-title":"Seizures in acute childhood stroke","volume":"160","author":"R K Singh","year":"2012","journal-title":"J Pediatr"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1001\/jamaneurol.2013.1033","article-title":"Pediatric intracerebral hemorrhage: acute symptomatic seizures and epilepsy","volume":"70","author":"L A Beslow","year":"2013","journal-title":"JAMA Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.yebeh.2018.08.012","article-title":"Clinical and 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