{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:54:07Z","timestamp":1756461247186,"version":"3.37.3"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"S 02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Diagnostic criteria for otogenic skull base osteomyelitis (SBO) have been conflicting among researchers. We aimed to propose clinically useful diagnostic criteria and a staging system for otogenic SBO that is associated with infection control and mortality.<\/jats:p><jats:p>\n          Design\u2003The present study is designed as a retrospective one.<\/jats:p><jats:p>\n          Setting\u2003This study was conducted at the University Hospital.<\/jats:p><jats:p>\n          Participants\u2003Thirteen patients with otogenic SBO who met the novel rigorous diagnostic criteria consisted of symptomatic and radiological signs on high-resolution computed tomography (HRCT) and magnetic resonance imaging (MRI). Simple refractory external otitis was not included. A staging system according to disease extent revealed by HRCT and MRI is proposed: lesions limited to the temporal bone (stage 1), extending to less than half (stage 2), exceeding the midline (stage 3), and extending to the whole of the clivus (stage 4). All patients received long-term antibiotic therapy. Patients were divided into infection-uncontrolled or -controlled groups based on symptoms, otoscopic findings, and C-reactive protein level at the last follow-up. The mean follow-up period was 27.7 months.<\/jats:p><jats:p>\n          Main Outcome Measures\u2003Possible prognostic factors, such as immunocompromised status and symptoms, including cranial nerve palsy, pretreatment laboratory data, and treatments, were compared between the infection-uncontrolled and -controlled groups. Disease stages were correlated with infection control and mortality.<\/jats:p><jats:p>\n          Results\u2003The infection-uncontrolled rate and mortality rate were 38.5 and 23.1%, respectively. There were no significant differences in possible prognostic factors between the infection-uncontrolled and -controlled groups. HRCT-based stages significantly correlated with infection control and mortality.<\/jats:p><jats:p>\n          Conclusion\u2003We proposed here the clinically useful diagnostic criteria and staging systems that can predict infection control and prognosis of otogenic SBO.<\/jats:p>","DOI":"10.1055\/s-0041-1732308","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T07:39:14Z","timestamp":1657525154000},"page":"e484-e491","source":"Crossref","is-referenced-by-count":3,"special_numbering":"S","title":["Optimal Diagnostic Criteria and a Staging System for Otogenic Skull Base Osteomyelitis"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-7728","authenticated-orcid":false,"given":"Kuniyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ogi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoriko","family":"Nonomura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiko","family":"Kitazawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arata","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1288\/00005537-195910000-00006","article-title":"Pyocyaneous osteomyelitis of the temporal bone, mandible and zygoma","volume":"69","author":"P Meltzer","year":"1959","journal-title":"Laryngoscope"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1288\/00005537-196808000-00002","article-title":"Malignant external otitis","volume":"78","author":"J R Chandler","year":"1968","journal-title":"Laryngoscope"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1288\/00005537-198603000-00003","article-title":"Osteomyelitis of the base of the skull","volume":"96","author":"J R Chandler","year":"1986","journal-title":"Laryngoscope"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/000348947208100505","article-title":"Pathogenesis and treatment of facial paralysis due to malignant external otitis","volume":"81","author":"J R Chandler","year":"1972","journal-title":"Ann Otol Rhinol 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