{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T04:52:22Z","timestamp":1758862342358},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003We aimed to find the clinical significance of brain abnormalities on magnetic resonance imaging (MRI) in epilepsy and the lateralization of these findings with electroencephalogram (EEG).<\/jats:p><jats:p>\n          Methods\u2003We retrospectively analyzed the results of all EEGs and brain MRIs of 600 consecutive epilepsy patients from 1998 to 2020.<\/jats:p><jats:p>\n          Results\u2003Data were available for 563 cases (267 females). Ninety percent of the patients were 18 years old or younger. A total of 345 patients (61.3%) had focal epilepsy, 180 (32%), generalized, and 38 (6.7%), inconclusive. In 187 (33.2%), the first MRI was abnormal and in 81 (out of 108 repeated MRI), the second was pathological. The most frequent brain abnormalities were cortical dysplasia in 41 (18.1%), other structural abnormalities in 25 (11%), various phacomatoses in 23 (10.1%), and mesial temporal sclerosis in 17 (7.5%). Among 226 patients with abnormal MRI, 171 (75.6%) had focal epilepsy when compared with 36 (15.9%) with generalized epilepsy (p &lt;0.001). In 121 patients (53.5%), the result of the abnormal MRI contributed significantly to the understanding of the epilepsy etiology. The side of abnormality was lateralized to the EEG focus in 120 cases (53%); in 10\/15 cases with infantile spasms (66%), MRI was significantly abnormal. In 33, in whom the first MRI was normal, a second MRI revealed a significant abnormality.<\/jats:p><jats:p>\n          Conclusion\u2003Brain MRI is an important tool in epilepsy diagnosis, mainly in focal seizures and infantile spasms. A repeat MRI is mandatory in intractable focal cases to improve the yield of this test.<\/jats:p>","DOI":"10.1055\/s-0041-1732325","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T05:13:07Z","timestamp":1627621987000},"page":"015-019","source":"Crossref","is-referenced-by-count":3,"title":["Yield of Brain Magnetic Resonance Imaging in Epilepsy Diagnosis from 1998 to 2020: A Large Retrospective Cohort Study"],"prefix":"10.1055","volume":"53","author":[{"given":"Tomer","family":"Stern","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liora","family":"Kornreich","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Neurology Department, Imaging Department, Schneider Children's Medical Center of Israel, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadassa","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Neurology Department, Epilepsy Center, Schneider Children's Medical Center of Israel, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neurol.2015.11.003","article-title":"Epidemiology of epilepsy","volume":"172","author":"C Behr","year":"2016","journal-title":"Rev Neurol (Paris)"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/WCO.0b013e328328f260","article-title":"The current status of neuroimaging for epilepsy","volume":"22","author":"J Duncan","year":"2009","journal-title":"Curr Opin Neurol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/jnnp-2011-301763","article-title":"Trends in presurgical evaluation and surgical treatment of epilepsy at one centre from 1988-2009","volume":"84","author":"C G Bien","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/WCO.0000000000000539","article-title":"MRI in epilepsy: clinical standard and evolution","volume":"31","author":"T R\u00fcber","year":"2018","journal-title":"Curr Opin Neurol"},{"issue":"09","key":"ref5","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/j.1528-1167.2011.03155.x","article-title":"Epilepsy imaging study guideline criteria: commentary on diagnostic testing study guidelines and practice parameters","volume":"52","author":"W D Gaillard","year":"2011","journal-title":"Epilepsia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1093\/brain\/awp187","article-title":"Frequency, prognosis and surgical treatment of structural abnormalities seen with magnetic resonance imaging in childhood epilepsy","volume":"132","author":"A T Berg","year":"2009","journal-title":"Brain"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1528-1157.2001.081421.x","article-title":"Advances in neuroimaging: surgical localization","volume":"42","author":"G D Cascino","year":"2001","journal-title":"Epilepsia"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","article-title":"Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009","volume":"51","author":"A T Berg","year":"2010","journal-title":"Epilepsia"},{"key":"ref9","volume-title":"BMDP Statistical Software","author":"W J Dixon","year":"1993"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology","volume":"58","author":"I E Scheffer","year":"2017","journal-title":"Epilepsia"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1684\/epd.2009.0262","article-title":"Imaging of malformations of cortical development","volume":"11","author":"N Colombo","year":"2009","journal-title":"Epileptic Disord"},{"issue":"17","key":"ref12","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1056\/NEJMoa1703784","article-title":"EEBB consortium. 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