{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:40Z","timestamp":1740126820096,"version":"3.37.3"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to evaluate if early (within the first 3\u2009hours after birth) transient neonatal hypoglycemia (TNH) is associated with poor academic performance in infants at-risk for hypoglycemia.<\/jats:p><jats:p>\n            Study Design\u2003This was a retrospective cohort study of at risk-infants (late preterm infants, small and large for gestational age infants, and infants of diabetic mothers [IDMs]) who were born in 1998 and 1999 at the University of Arkansas for Medical Sciences and had \u22651 recorded glucose concentration. The outcome measure was proficiency on 4th grade literacy and mathematics achievement tests. Three glucose concentration cutoffs for defining hypoglycemia (&lt;35, &lt;40, and &lt;45\u2009mg\/dL) were investigated. Logistic regression models were developed to examine the association between early TNH and achievement test proficiency based on perinatal factors.<\/jats:p><jats:p>\n            Results\u2003Among 726 infants, 472 had one, 233 had two, and 21 had three risk factor(s). Early TNH (glucose concentration &lt;35, &lt;40, and &lt;45\u2009mg\/dL) was observed in 6.3, 11.6, and 20.5% of the study cohort, respectively. Irrespective of the cutoff used, the frequency of early TNH (number of patients with early TNH in a risk category divided by the total number of patients in that category) was significantly greater among infants with multiple risk factors. After controlling for perinatal factors, early TNH (cutoffs &lt;35 and &lt;40\u2009mg\/dL) was significantly associated with decreased probability of proficiency in literacy but not mathematics. Despite that early TNH was more common in IDMs and infants with three risk factors, the category or number of risk factors did not impact academic proficiency.<\/jats:p><jats:p>\n            Conclusion\u2003Early TNH (&lt;35 and &lt;40\u2009mg\/dL) was associated with lower adjusted probability of proficiency on 4th grade literacy achievement tests in at-risk infants. The impact of early TNH on academic performance was similar irrespective of category or number of risk factors.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1732380","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:45:07Z","timestamp":1627692307000},"page":"1096-1105","source":"Crossref","is-referenced-by-count":7,"title":["Early Transient Hypoglycemia and Test Performance in At-Risk Newborns"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0868-8420","authenticated-orcid":false,"given":"Nahed O.","family":"ElHassan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neonatal-Perinatal Medicine), University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric W.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Penn State College of Medicine, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basilia","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Lifelong Medicare Care, Richmond, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1972-7002","authenticated-orcid":false,"given":"Thomas","family":"Nienaber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neonatal-Perinatal Medicine), University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-0132","authenticated-orcid":false,"given":"Luc P.","family":"Brion","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neonatal-Perinatal Medicine), University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (Neonatal-Perinatal Medicine) and Obstetrics and Gynecology, Penn State Health Children's Hospital, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jpeds.2009.06.044","article-title":"Knowledge gaps and research needs for understanding and treating neonatal hypoglycemia: workshop report from Eunice Kennedy Shriver National Institute of Child Health and Human Development","volume":"155","author":"W W Hay Jr","year":"2009","journal-title":"J Pediatr"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1542\/peds.105.5.1141","article-title":"Controversies regarding definition of neonatal 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