{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:04:21Z","timestamp":1760385861312,"version":"3.37.3"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n            Objective\u2003The aim of the study is to compare the duration of oxygen therapy by using two methods of weaning from nasal continuous positive airway pressure (nCPAP) in very preterm babies.<\/jats:p><jats:p>\n            Study Design\u2003Between April 2014 and December 2016, 90 preterm &lt;32 weeks and birthweight &gt;1,000\u2009g who, after at least 7 days on nCPAP, were clinically stable on &lt;6\u2009cm H2O and FiO2 &lt;30% were randomly assigned to weaning directly from nCPAP or with nasal high flow therapy (nHFT). In the nCPAP group, pressure was gradually reduced until the infant was stable on 4\u2009cm H2O and then discontinued. In the nHFT group, flow rate was reduced until the infant was stable at 3.l pm and then discontinued.<\/jats:p><jats:p>\n            Results\u2003Eighty-four infants completed the study. There were no differences between the groups for the primary outcome, duration of oxygen therapy (median 33 [14\u201348] versus 28 [15\u201337] days; p\u2009=\u20090.17). The incidence of moderate-to-severe bronchopulmonary dysplasia was similar. Weaning time was shorter in the nCPAP group (p\u2009=\u20090.02), but the failure rate was slightly higher although non-significant. In the nHFT group, we observed better perception of patient comfort and a lower incidence of severe nasal injury.<\/jats:p><jats:p>\n            Conclusion\u2003Weaning by nHFT compared with weaning directly off nCPAP does not prolong duration of oxygen therapy. Rather, it is associated with better perceptions of infant comfort among parents and lower rates of severe nasal injury.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1732422","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T06:30:53Z","timestamp":1629095453000},"page":"937-944","source":"Crossref","is-referenced-by-count":2,"title":["Nasal High-Flow for Weaning Preterm Newborns with Risk of Chronic Lung Disease from nCPAP"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9989-8030","authenticated-orcid":false,"given":"Angela","family":"Gregoraci Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Vall d'Hebron Hospital, Barcelona, Spain"},{"name":"Department of Neonatology, Doctor Josep Trueta Hospital, Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"Comu\u00f1as G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Vall d'Hebron Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olalla","family":"Rodriguez-Losada","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Vall d'Hebron Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Flores Espa\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Vall d'Hebron Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gros Turpin","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Vall d'Hebron Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"P\u00e9rez Hoyos","sequence":"additional","affiliation":[{"name":"Statistics and Bioinformatics Unit, Vall d'Hebron Research Institute, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Castillo Salinas","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Vall d'Hebron Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000499361","article-title":"European Consensus guidelines on the management of respiratory distress syndrome\u20132019 update","volume":"115","author":"D G Sweet","year":"2019","journal-title":"Neonatology"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.clp.2016.07.005","article-title":"Nasal high-flow therapy for preterm infants: review of neonatal trial data","volume":"43","author":"B J Manley","year":"2016","journal-title":"Clin 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