{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:38:18Z","timestamp":1777937898504,"version":"3.51.4"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n            Objective\u2003This study was aimed to assess the association between ovarian hyperstimulation syndrome (OHSS) and pregnancy complications among women who conceived following fertility treatment.<\/jats:p><jats:p>\n            Study Design\u2003A retrospective population-based cohort study, including all singleton deliveries of patients conceived following ovulation induction (OI) or in vitro fertilization (IVF) between 1988 and 2016, was conducted. All births occurred in a single tertiary medical center. A comparison was performed between deliveries of women who had experienced OHSS at early gestation and subsequently had a pregnancy and women without OHSS. Women lacking prenatal care, multiple gestations, and stillbirths were excluded from the analyses. A multivariable logistic regression model was used to control for confounders.<\/jats:p><jats:p>\n            Results\u2003During the study period, 351,373 deliveries met the inclusion criteria, of which 6,748 were deliveries of infants who were conceived by either IVF or OI. Of this study population, 105 cases (1.6%) composed the exposed group, that is, women who had experienced OHSS with a subsequent live birth. In the multivariate analyses, after controlling for confounders, OHSS was not found as an independent risk factor for preeclampsia, gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR), preterm delivery (both &lt;37 and &lt;34 weeks), low birth weight (LBW), very LBW (VLBW), small for gestational age (SGA), and caesarean delivery. In a subanalysis conducted solely on the IVF population, similar results were found, aside from the association between OHSS and preterm delivery before 34 weeks of gestation which was statistically significant (adjusted odds ratio [AOR]\u2009=\u20092.3 95% confidence interval [CI]: 1.0\u20135.3, p\u2009=\u20090.049).<\/jats:p><jats:p>\n            Conclusion\u2003In our population, OHSS was not found as a risk factor for adverse pregnancy and perinatal outcome. In IVF patients, OHSS is a risk factor for preterm delivery before 34 weeks of gestation.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1732458","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T05:14:56Z","timestamp":1627622096000},"page":"1088-1095","source":"Crossref","is-referenced-by-count":4,"title":["The Association between Ovarian Hyperstimulation Syndrome and Pregnancy Complications following Fertility Treatments"],"prefix":"10.1055","volume":"40","author":[{"given":"Shirah","family":"Vainer-Rotbart","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Health Sciences Ben Gurion University of the Negev, Givatayim, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Harlev","sequence":"additional","affiliation":[{"name":"Fertility and IVF Unit, Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Health Sciences Ben Gurion University of the Negev, Givatayim, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/01.AOG.0000114989.84822.51","article-title":"Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis","volume":"103","author":"R A Jackson","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"13","key":"ref2","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.3109\/14767058.2013.856415","article-title":"Perinatal outcome of pregnancies following in vitro fertilization and ovulation induction","volume":"27","author":"T Silberstein","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/ppul.24428","article-title":"Fertility treatments and the risk of pediatric obstructive sleep apnea in the offspring-Results from a population-based cohort study","volume":"54","author":"M Imterat","year":"2019","journal-title":"Pediatr Pulmonol"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"314.e1","DOI":"10.1016\/j.ajog.2017.01.015","article-title":"Fertility treatments and pediatric neoplasms of the offspring: results of a population-based cohort with a median follow-up of 10 years","volume":"216","author":"T Wainstock","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1196\/annals.1365.021","article-title":"Prevention and management of ovarian hyperstimulation syndrome","volume":"1092","author":"N F Vlahos","year":"2006","journal-title":"Ann N Y Acad Sci"},{"issue":"07","key":"ref6","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.fertnstert.2016.08.048","article-title":"Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline","volume":"106","author":"S Pfeifer","year":"2016","journal-title":"Fertil Steril"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/humupd\/8.6.559","article-title":"Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review","volume":"8","author":"A Delvigne","year":"2002","journal-title":"Hum Reprod Update"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1056\/NEJMoa030065","article-title":"A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome","volume":"349","author":"C Vasseur","year":"2003","journal-title":"N Engl J Med"},{"issue":"08","key":"ref9","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1056\/NEJMoa030064","article-title":"Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor","volume":"349","author":"G Smits","year":"2003","journal-title":"N Engl J Med"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0015-0282(98)00221-0","article-title":"Changes in vascular endothelial growth factor levels and the risk of ovarian hyperstimulation syndrome in women enrolled in an in vitro fertilization program","volume":"70","author":"P G Artini","year":"1998","journal-title":"Fertil Steril"},{"key":"ref11","first-page":"CD008605","article-title":"Dopamine agonists for preventing ovarian hyperstimulation syndrome","volume":"11","author":"H Tang","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"07","key":"ref12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ogrm.2012.03.003","article-title":"Ovarian hyperstimulation syndrome: Clinical features, prevention and management","volume":"22","author":"H Borase","year":"2012","journal-title":"Obstetrics, Gynaecol Reprod Med"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/S0015-0282(98)00350-1","article-title":"Obstetric outcome of in vitro fertilized pregnancies complicated by severe ovarian hyperstimulation syndrome: a multicenter study","volume":"70","author":"Y Abramov","year":"1998","journal-title":"Fertil Steril"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.fertnstert.2010.12.015","article-title":"Obstetric outcome of women with in vitro fertilization pregnancies hospitalized for ovarian hyperstimulation syndrome: a case-control study","volume":"95","author":"B Courbiere","year":"2011","journal-title":"Fertil Steril"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.rbmo.2014.04.015","article-title":"Is severe OHSS associated with adverse pregnancy outcomes? Evidence from a case-control study","volume":"29","author":"J Haas","year":"2014","journal-title":"Reprod Biomed Online"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.fertnstert.2009.05.092","article-title":"Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome","volume":"94","author":"B Luke","year":"2010","journal-title":"Fertil Steril"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.fertnstert.2006.04.038","article-title":"Factors influencing adverse perinatal outcomes in pregnancies achieved through use of in vitro fertilization","volume":"86","author":"K Chung","year":"2006","journal-title":"Fertil Steril"},{"issue":"23","key":"ref18","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.4103\/0366-6999.170280","article-title":"Pregnancy outcomes of in vitro fertilization with or without ovarian hyperstimulation syndrome: A retrospective cohort study in Chinese patients","volume":"128","author":"X Jiang","year":"2015","journal-title":"Chin Med J (Engl)"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/humrep\/deh713","article-title":"Outcome of pregnancies complicated by severe ovarian hyperstimulation syndrome (OHSS): a follow-up beyond the second trimester","volume":"20","author":"A Wiser","year":"2005","journal-title":"Hum Reprod"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.fertnstert.2017.07.1160","article-title":"Severe ovarian hyperstimulation syndrome modifies early maternal serum beta-human chorionic gonadotropin kinetics, but obstetrical and neonatal outcomes are not impacted","volume":"108","author":"C Choux","year":"2017","journal-title":"Fertil Steril"},{"issue":"08","key":"ref21","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1471-0528.2000.tb10393.x","article-title":"Is ovarian hyperstimulation syndrome associated with a poor obstetric outcome?","volume":"107","author":"R S Mathur","year":"2000","journal-title":"BJOG"},{"issue":"02","key":"ref23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0301-2115(97)00178-4","article-title":"Decisions regarding pregnancy termination among Bedouin couples referred to third level ultrasound clinic","volume":"76","author":"E Sheiner","year":"1998","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00404-011-2153-x","article-title":"Lack of prenatal care in a traditional community: trends and perinatal outcomes","volume":"285","author":"S Abu-Ghanem","year":"2012","journal-title":"Arch Gynecol Obstet"},{"issue":"08","key":"ref25","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2105\/AJPH.92.8.1323","article-title":"The impact of the increasing number of multiple births on the rates of preterm birth and low birthweight: an international study","volume":"92","author":"B Blondel","year":"2002","journal-title":"Am J Public Health"},{"issue":"09","key":"ref26","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s40618-017-0646-6","article-title":"Analysis of the main risk factors for gestational diabetes diagnosed with International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria in multiple pregnancies","volume":"40","author":"M Cozzolino","year":"2017","journal-title":"J Endocrinol Invest"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/jhh.2012.13","article-title":"Assisted reproductive technology and pregnancy-related hypertensive complications: a systematic review","volume":"27","author":"C Thomopoulos","year":"2013","journal-title":"J Hum Hypertens"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10815-017-1074-4","article-title":"A novel oocyte maturation trigger using 1500\u2009IU of human chorionic gonadotropin plus 450\u2009IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols","volume":"35","author":"Y Anaya","year":"2018","journal-title":"J Assist Reprod Genet"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s10815-017-1010-7","article-title":"GnRH antagonist administered twice the day before hCG trigger combined with a step-down protocol may prevent OHSS in IVF\/ICSI antagonist cycles at risk for OHSS without affecting the reproductive outcomes: a prospective randomized control trial","volume":"34","author":"Y Prapas","year":"2017","journal-title":"J Assist Reprod Genet"},{"issue":"05","key":"ref30","first-page":"CD002811","article-title":"Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome","volume":"5","author":"A D'Angelo","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"01","key":"ref31","first-page":"CD012103","article-title":"Interventions for the prevention of OHSS in ART cycles: an overview of Cochrane reviews","volume":"1","author":"S Mourad","year":"2017","journal-title":"Cochrane Database Syst Rev"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1732458.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:09:24Z","timestamp":1689034164000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1732458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,7,10]]},"published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1732458","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]}}}