{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:19:14Z","timestamp":1771993154525,"version":"3.50.1"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Aarhus University, Aarhus, Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Remote ischemic conditioning (RIC) is administered with an inflatable tourniquet by inducing brief, alternating cycles of limb ischemia and reperfusion. RIC possibly impacts the hemostatic system, and the intervention has been tested as protective therapy against ischemia-reperfusion injury and thrombotic complications in cardiac surgery and other surgical procedures. In the present systematic review, we aimed to investigate the effect of RIC on intraoperative and postoperative bleeding complications in meta-analyses of randomized controlled trials including adult patients undergoing surgery. A systematic search was performed on November 7, 2020 in PubMed, Embase, and the Cochrane Central Register of Controlled Trials. Randomized controlled trials comparing RIC versus no RIC in adult patients undergoing surgery that reported bleeding outcomes in English publications were included. Effect estimates with 95% confidence intervals were calculated using the random-effects model for intraoperative and postoperative bleeding outcomes. Thirty-two randomized controlled trials with 3,804 patients were eligible for inclusion. RIC did not affect intraoperative bleeding volume (nine trials; 392 RIC patients, 399 controls) with the effect estimate \u22120.95 [\u22129.90; 7.99] mL (p\u2009=\u20090.83). RIC significantly reduced postoperative drainage volume (seven trials; 367 RIC patients, 365 controls) with mean difference \u221283.6 [\u2212134.9; \u221232.4] mL (p\u2009=\u20090.001). The risk of re-operation for bleeding was reduced in the RIC group (16 trials; 838 RIC patients, 839 controls), albeit not significantly, with the relative risk 0.65 [0.39; 1.09] (p\u2009=\u20090.10). In conclusion, RIC reduced postoperative bleeding measured by postoperative drainage volume in this meta-analysis of adult patients undergoing surgery.<\/jats:p>","DOI":"10.1055\/s-0041-1732468","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T22:54:41Z","timestamp":1629845681000},"page":"229-239","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Remote Ischemic Conditioning on Bleeding Complications in Surgery: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"48","author":[{"given":"Andreas E.","family":"Krag","sequence":"additional","affiliation":[{"name":"Thrombosis and Hemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Plastic and Breast Surgery, Aarhus University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine L.","family":"Hvas","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte J.","family":"Kiil","sequence":"additional","affiliation":[{"name":"Department of Plastic and Breast Surgery, Aarhus University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Thrombosis and Hemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"C E Murry","year":"1986","journal-title":"Circulation"},{"issue":"23","key":"ref2","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1161\/01.CIR.0000043806.51912.9B","article-title":"Transient limb ischemia induces remote ischemic preconditioning in vivo","volume":"106","author":"R K Kharbanda","year":"2002","journal-title":"Circulation"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00000658-200008000-00001","article-title":"Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans","volume":"232","author":"P A Clavien","year":"2000","journal-title":"Ann Surg"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/01.sla.0000098620.27623.7d","article-title":"A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning","volume":"238","author":"P A Clavien","year":"2003","journal-title":"Ann Surg"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"H1883","DOI":"10.1152\/ajpheart.00617.2006","article-title":"Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning","volume":"292","author":"M R Schmidt","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"05","key":"ref6","first-page":"404","article-title":"Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors","volume":"100","author":"F Kerendi","year":"2005","journal-title":"Basic Res Cardiol"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1111\/j.1538-7836.2012.04914.x","article-title":"Remote ischemic preconditioning reduces thrombus formation in the rat","volume":"10","author":"D M R\u00f8pcke","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.113.005336","article-title":"Effect of remote ischemic preconditioning on platelet activation and reactivity induced by ablation for atrial fibrillation","volume":"129","author":"A Stazi","year":"2014","journal-title":"Circulation"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.amjcard.2015.10.056","article-title":"Effect of remote ischemic preconditioning on platelet activation induced by coronary procedures","volume":"117","author":"G A Lanza","year":"2016","journal-title":"Am J Cardiol"},{"issue":"07","key":"ref10","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1055\/s-0037-1604088","article-title":"Ischemic conditioning as a hemostatic intervention in surgery and cardiac procedures: a systematic review","volume":"43","author":"A E Krag","year":"2017","journal-title":"Semin Thromb Hemost"},{"issue":"15","key":"ref11","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa1413579","article-title":"A multicenter trial of remote ischemic preconditioning for heart surgery","volume":"373","author":"P Meybohm","year":"2015","journal-title":"N Engl J Med"},{"issue":"15","key":"ref12","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1056\/NEJMoa1413534","article-title":"Remote ischemic preconditioning and outcomes of cardiac surgery","volume":"373","author":"D J Hausenloy","year":"2015","journal-title":"N Engl J Med"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"e0219496","DOI":"10.1371\/journal.pone.0219496","article-title":"Effect of remote ischemic preconditioning on hemostasis and fibrinolysis in head and neck cancer surgery: a randomized controlled trial","volume":"14","author":"A E Krag","year":"2019","journal-title":"PLoS One"},{"issue":"02","key":"ref14","first-page":"79","article-title":"Ischemic preconditioning improves postoperative outcome after liver resections: a randomized controlled study","volume":"13","author":"O Heizmann","year":"2008","journal-title":"Eur J Med Res"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.surg.2015.10.011","article-title":"A network meta-analysis comparing perioperative outcomes of interventions aiming to decrease ischemia reperfusion injury during elective liver resection","volume":"159","author":"C Simillis","year":"2016","journal-title":"Surgery"},{"issue":"48","key":"ref16","doi-asserted-by":"crossref","first-page":"e8217","DOI":"10.1097\/MD.0000000000008217","article-title":"Meta-analysis of ischemic preconditioning (IP) on postoperative outcomes after liver resections","volume":"96","author":"X Guo","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"13","key":"ref17","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/bjs.9277","article-title":"Meta-analysis of ischaemic preconditioning for liver resections","volume":"100","author":"S O'Neill","year":"2013","journal-title":"Br J Surg"},{"issue":"07","key":"ref18","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"J PT Higgins","year":"2011","journal-title":"BMJ"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/eurheartj\/eht346","article-title":"Does remote ischaemic preconditioning with postconditioning improve clinical outcomes of patients undergoing cardiac surgery? Remote Ischaemic Preconditioning with Postconditioning Outcome Trial","volume":"35","author":"D M Hong","year":"2014","journal-title":"Eur Heart J"},{"issue":"05","key":"ref21","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1007\/s00268-016-3823-4","article-title":"Effect of remote ischaemic preconditioning on liver Injury in patients undergoing major hepatectomy for colorectal liver metastasis: a pilot randomised controlled feasibility trial","volume":"41","author":"S Kanoria","year":"2017","journal-title":"World J Surg"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12916-017-0898-1","article-title":"Impact of ischemic preconditioning on surgical treatment of brain tumors: a single-center, randomized, double-blind, controlled trial","volume":"15","author":"A HA Sales","year":"2017","journal-title":"BMC Med"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.healun.2014.04.022","article-title":"Safety, feasibility, and effect of remote ischemic conditioning in patients undergoing lung transplantation","volume":"33","author":"E Lin","year":"2014","journal-title":"J Heart Lung Transplant"},{"issue":"02","key":"ref24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/ALN.0000000000000266","article-title":"Limb remote ischemic preconditioning attenuates lung injury after pulmonary resection under propofol-remifentanil anesthesia: a randomized controlled study","volume":"121","author":"C Li","year":"2014","journal-title":"Anesthesiology"},{"issue":"05","key":"ref25","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1053\/j.jvca.2014.04.018","article-title":"Remote ischemic preconditioning does not affect the incidence of acute kidney injury after elective abdominal aortic aneurysm repair","volume":"28","author":"N Murphy","year":"2014","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/aas.13724","article-title":"The effect of remote ischaemic preconditioning on endothelial function after hip fracture surgery","volume":"65","author":"S Ekeloef","year":"2021","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.thromres.2020.01.004","article-title":"Effect of remote ischaemic conditioning on coagulation function as measured by whole blood impedance aggregometry and rotational thromboelastometry in off-pump coronary artery bypass surgery: a randomised controlled trial","volume":"187","author":"T K Kim","year":"2020","journal-title":"Thromb Res"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jtcvs.2018.08.116","article-title":"Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection","volume":"157","author":"H Gasparovic","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00395-019-0723-4","article-title":"Remote ischaemic preconditioning ameliorates sinus rhythm restoration rate through Cox maze radiofrequency procedure associated with inflammation reaction reduction","volume":"114","author":"Q Jiang","year":"2019","journal-title":"Basic Res Cardiol"},{"issue":"05","key":"ref30","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/ejcts\/ezy404","article-title":"Remote ischaemic preconditioning in isolated aortic valve and coronary artery bypass surgery: a randomized trial","volume":"55","author":"M Moscarelli","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"issue":"06","key":"ref31","first-page":"587","article-title":"The effect of remote ischemic preconditioning on the incidence of acute kidney injury in patients undergoing coronary artery bypass graft surgery: a randomized controlled trial","volume":"43","author":"S Bagheri","year":"2018","journal-title":"Iran J Med Sci"},{"issue":"05","key":"ref32","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.bja.2018.07.035","article-title":"Remote ischaemic conditioning for prevention of acute kidney injury after valvular heart surgery: a randomised controlled trial","volume":"121","author":"J W Song","year":"2018","journal-title":"Br J Anaesth"},{"key":"ref33","first-page":"103","article-title":"Remote preconditioning might protect the kidney in heart surgery","volume":"24","author":"F Yildirim","year":"2018","journal-title":"GKDAD Derg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ijcard.2016.10.111","article-title":"Effects of delayed remote ischemic preconditioning on peri-operative myocardial injury in patients undergoing cardiac surgery\u2014a randomized controlled trial","volume":"227","author":"T K Kim","year":"2017","journal-title":"Int J Cardiol"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jss.2015.06.053","article-title":"Multiorgan protection of remote ischemic perconditioning in valve replacement surgery","volume":"200","author":"Q Hu","year":"2016","journal-title":"J Surg Res"},{"issue":"01","key":"ref36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jjcc.2015.06.007","article-title":"Remote ischemic preconditioning in aortic valve surgery: results of a randomized controlled study","volume":"67","author":"F Pinaud","year":"2016","journal-title":"J Cardiol"},{"issue":"01","key":"ref37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/j.jvca.2015.06.027","article-title":"Is \u201cattenuation of oxidative stress\u201d helpful to understand the mechanism of remote ischemic preconditioning in cardiac surgery?","volume":"30","author":"F Yildirim","year":"2016","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"02","key":"ref38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/ki.2014.259","article-title":"Remote ischemic preconditioning has a neutral effect on the incidence of kidney injury after coronary artery bypass graft surgery","volume":"87","author":"S M Gallagher","year":"2015","journal-title":"Kidney Int"},{"issue":"03","key":"ref39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/14017431.2015.1010565","article-title":"Remote ischemic preconditioning and incidence of postoperative atrial fibrillation","volume":"49","author":"L E Krogstad","year":"2015","journal-title":"Scand Cardiovasc J"},{"issue":"04","key":"ref40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/14017431.2014.923930","article-title":"Conditioning techniques and ischemic reperfusion injury in relation to on-pump cardiac surgery","volume":"48","author":"F E Holmberg","year":"2014","journal-title":"Scand Cardiovasc J"},{"issue":"05","key":"ref41","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4097\/kjae.2013.65.5.418","article-title":"Effect of remote ischemic preconditioning on cognitive function after off-pump coronary artery bypass graft: a pilot study","volume":"65","author":"K W Joung","year":"2013","journal-title":"Korean J Anesthesiol"},{"issue":"01","key":"ref42","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/icvts\/ivs118","article-title":"Remote ischaemic preconditioning does not protect the heart in patients undergoing coronary artery bypass grafting","volume":"15","author":"V V Lomivorotov","year":"2012","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"01","key":"ref43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jtcvs.2010.11.018","article-title":"Effect of remote ischemic preconditioning on renal dysfunction after complex valvular heart surgery: a randomized controlled trial","volume":"142","author":"Y S Choi","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"01","key":"ref44","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jss.2010.06.016","article-title":"Remote perconditioning reduces myocardial injury in adult valve replacement: a randomized controlled trial","volume":"164","author":"L Li","year":"2010","journal-title":"J Surg Res"},{"issue":"04","key":"ref45","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/SLA.0000000000003498","article-title":"Effect of remote ischemic preconditioning conducted in living liver donors on postoperative liver function in donors and recipients following liver transplantation: a randomized clinical trial","volume":"271","author":"K W Jung","year":"2020","journal-title":"Ann Surg"},{"issue":"05","key":"ref46","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/jcm8050713","article-title":"Impact of remote ischemic preconditioning conducted in living kidney donors on renal function in donors and recipients following living donor kidney transplantation: a randomized clinical trial","volume":"8","author":"J Y Bang","year":"2019","journal-title":"J Clin Med"},{"issue":"31","key":"ref47","doi-asserted-by":"crossref","first-page":"e1316","DOI":"10.1097\/MD.0000000000001316","article-title":"A double blind randomized clinical trial of remote ischemic conditioning in live donor renal transplantation","volume":"94","author":"M L Nicholson","year":"2015","journal-title":"Medicine (Baltimore)"},{"issue":"05","key":"ref48","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/TP.0000000000000098","article-title":"The effect of remote ischemic postconditioning on graft function in patients undergoing living donor kidney transplantation","volume":"98","author":"W H Kim","year":"2014","journal-title":"Transplantation"},{"issue":"11","key":"ref49","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/lt.23960","article-title":"Effect of remote ischemic postconditioning on patients undergoing living donor liver transplantation","volume":"20","author":"W H Kim","year":"2014","journal-title":"Liver Transpl"},{"issue":"09","key":"ref50","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.hpb.2019.12.002","article-title":"Effect of remote ischemic preconditioning on liver injury in patients undergoing liver resection: the ERIC-LIVER trial","volume":"22","author":"J Y Teo","year":"2020","journal-title":"HPB (Oxford)"},{"issue":"03","key":"ref51","first-page":"252","article-title":"Effect of remote ischemic preconditioning on hepatic ischemia-reperfusion injury in patients undergoing liver resection: a randomized controlled trial","volume":"86","author":"G Wu","year":"2020","journal-title":"Minerva Anestesiol"},{"issue":"06","key":"ref52","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1213\/ANE.0000000000004434","article-title":"Effect of remote ischemic preconditioning in patients undergoing hepatectomy with portal triad clamping: a randomized controlled trial","volume":"129","author":"X Liu","year":"2019","journal-title":"Anesth Analg"},{"issue":"17","key":"ref53","doi-asserted-by":"crossref","first-page":"e6719","DOI":"10.1097\/MD.0000000000006719","article-title":"Remote ischemic preconditioning improves the cognitive function of elderly patients following colon surgery: a randomized clinical trial","volume":"96","author":"Z He","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"ref54","doi-asserted-by":"crossref","first-page":"e003916","DOI":"10.1161\/JAHA.116.003916","article-title":"Cardiac remote ischemic preconditioning prior to elective vascular surgery (CRIPES): a prospective, randomized, sham-controlled phase II clinical trial","volume":"5","author":"S Garcia","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"04","key":"ref55","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/ALN.0b013e3182850da5","article-title":"Limb remote ischemic preconditioning for intestinal and pulmonary protection during elective open infrarenal abdominal aortic aneurysm repair: a randomized controlled trial","volume":"118","author":"C Li","year":"2013","journal-title":"Anesthesiology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"l6395","DOI":"10.1136\/bmj.l6395","article-title":"The effect of remote ischaemic preconditioning on myocardial injury in emergency hip fracture surgery (PIXIE trial): phase II randomised clinical trial","volume":"367","author":"S Ekeloef","year":"2019","journal-title":"BMJ"},{"issue":"02","key":"ref57","doi-asserted-by":"crossref","first-page":"115","DOI":"10.7150\/ijms.17227","article-title":"Impact of remote ischaemic preconditioning on cerebral oxygenation during total knee arthroplasty","volume":"14","author":"C S Oh","year":"2017","journal-title":"Int J Med Sci"}],"container-title":["Seminars in Thrombosis and Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1732468.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:53:40Z","timestamp":1646096020000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1732468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":57,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,2,28]]},"published-print":{"date-parts":[[2022,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1732468","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0094-6176","1098-9064"],"issn-type":[{"value":"0094-6176","type":"print"},{"value":"1098-9064","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,24]]}}}