{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:19:12Z","timestamp":1783138752554,"version":"3.54.6"},"reference-count":21,"publisher":"Necmettin Erbakan University Press","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Genet"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acetabular protrusion (AP) is present in 33 to 55% of patients with osteogenesis imperfecta (OI). Even though the finding is relatively common, it is poorly described in pediatric patients. The objective of this study was to describe the incidence and associations of AP in pediatric OI patients. We retrospectively and cross-sectionally evaluated clinical histories and radiographic findings of OI patients aged 2 to 19.5 years, recording sex, age, severity, anthropometric measurements, ambulation status, femoral fractures history, and occurrence of orthopaedic surgeries and nephropathy. AP was considered present when the center-edge (CE) angle was more than 35 degrees and the acetabular line crossed the Kohler's line by more than 1 and 3\u2009mm in boys and girls, respectively, and 3 and 6\u2009mm in adult males and females, respectively. The association with risk factors and complications was analyzed through univariate and multivariate logistic regression. A total of 71 children were evaluated. The median age was 8.6 years, and 54.9% of them had moderate to severe forms of OI. In 71.8% of the children, an abnormal CE angle was found, being frequent in mild, moderate, and severe cases. AP was present in 22.5% of all patients and in 41% of children with moderate to severe OI, and was significantly associated with older ages (p\u2009=\u20090.0062) and nonwalking status (p\u2009=\u20090.0093). We found a high prevalence of AP in children with moderate to severe forms of OI, which was present even at younger ages. In addition, we found a significant increase in the number of children with abnormal CE angles even in those with mild forms of OI. The presence of AP was associated with the severity of the OI and age, and in a negative association with the ambulatory status.<\/jats:p>","DOI":"10.1055\/s-0041-1732476","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T18:58:10Z","timestamp":1626980290000},"page":"048-052","source":"Crossref","is-referenced-by-count":3,"title":["Acetabular Protrusion in a Cohort of Patients with Osteogenesis Imperfecta Evaluated in a Pediatric Hospital"],"prefix":"10.53391","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1717-2805","authenticated-orcid":false,"given":"Rosario","family":"Ramos-Mej\u00eda","sequence":"additional","affiliation":[{"name":"Department of Growth and Development, Paediatric Hospital Dr Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Monterroza-Quintana","sequence":"additional","affiliation":[{"name":"Department of Growth and Development, Paediatric Hospital Dr Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Primomo","sequence":"additional","affiliation":[{"name":"Department of Growth and Development, Paediatric Hospital Dr Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-6050","authenticated-orcid":false,"given":"Rodolfo","family":"Goyeneche","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Paediatric Hospital Dr Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-2220","authenticated-orcid":false,"given":"Virginia","family":"Fano","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Paediatric Hospital Dr Juan P. Garrahan, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31409","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"issue":"465","key":"ref1","first-page":"6","article-title":"Intrapelvic protrusion of the acetabulum (Otto pelvis). 1932","volume":"465","author":"M M Pomeranz","year":"2007","journal-title":"Clin Orthop Relat Res"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3109\/00016923509137960","article-title":"Otto's disease and other forms of protrusio acetabuli","volume":"16","author":"K Overgaard","year":"1935","journal-title":"Acta Radiol"},{"key":"ref3","first-page":"w14322","article-title":"Osteogenesis imperfecta: from diagnosis and multidisciplinary treatment to future perspectives","volume":"146","author":"A Bregou Bourgeois","year":"2016","journal-title":"Swiss Med Wkly"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5435\/00124635-200103000-00002","article-title":"Protrusio acetabuli: diagnosis and treatment","volume":"9","author":"M T McBride","year":"2001","journal-title":"J Am Acad Orthop Surg"},{"issue":"S 58","key":"ref5","first-page":"53","article-title":"Studies on dysplastic acetabula and congenital subluxation of the hip joint","volume":"83","author":"G Wiberg","year":"1939","journal-title":"Acta Chir Scand"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/0002-9610(53)90565-0","article-title":"Protrusio acetabuli","volume":"85","author":"Z B Friedenberg","year":"1953","journal-title":"Am J Surg"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1302\/0301-620X.53B1.30","article-title":"Primary protrusio acetabuli","volume":"53-B","author":"D Mac Donald","year":"1971","journal-title":"J Bone Joint Surg."},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1148\/128.1.1","article-title":"The adult hip: an anatomic study. 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Evaluaci\u00f3n cl\u00ednica, funcional y multidisciplinaria de 65 pacientes","volume":"72","author":"V Fano","year":"2010","journal-title":"An Pediatr (Barc)"},{"issue":"03","key":"ref21","first-page":"248","article-title":"Osteogenesis imperfecta: level of independence and of social, recreational and sports participation among adolescents and youth","volume":"114","author":"M Rodr\u00edguez Celin","year":"2016","journal-title":"Arch Argent Pediatr"}],"container-title":["Journal of Pediatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1732476.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T19:46:04Z","timestamp":1758138364000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1732476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,22]]},"references-count":21,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,1,18]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1732476","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2146-4596","2146-460X"],"issn-type":[{"value":"2146-4596","type":"print"},{"value":"2146-460X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,22]]}}}