{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:59:09Z","timestamp":1792364349245,"version":"4.4.0"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n            Objective\u2003The study aimed to determine the association of surgical necrotizing enterocolitis (NEC) and its timing, with the development and timing of retinopathy of prematurity (ROP).<\/jats:p><jats:p>\n            Study Design\u2003This was a secondary data analysis of 7,483 preterm infants from the Postnatal Growth and Retinopathy of Prematurity Study. Associations between infants with surgical NEC, early-onset surgical NEC (8\u201328 days), and late-onset surgical NEC (over 28 days) with ROP were evaluated by using multivariable logistic regression models, controlling for birth weight, gestational age, small for gestational age status, chronic lung disease, intraventricular hemorrhage, hydrocephalus, patent ductus arteriosus, and periventricular leukomalacia.<\/jats:p><jats:p>\n            Results\u2003Three hundred fifty-six (4.8%) infants had surgical NEC, with 56% having early surgical NEC. Infants with surgical NEC had a higher risk of any ROP and severe ROP (adjusted odds ratio [OR]: 2.7; 95% CI: 1.9\u20133.7) and 2.5 (95% CI: 1.9\u20133.3), respectively; p\u2009&lt;\u20090.001) compared with infants without surgical NEC. Infants with early surgical NEC were at the highest risk of developing ROP and severe ROP (adjusted OR: 3.1 [95% CI: 2.1\u20134.8], and 3.3 [95% CI: 2.3\u20134.7] respectively, p\u2009&lt;\u20090.001). Infants with late surgical NEC were also at increased risk of developing ROP and severe ROP (adjusted OR: 2.1 [95% CI: 1.3\u20133.4], and 1.9 [95% CI: 1.3\u20132.8] respectively, p\u2009&lt;\u20090.001) compared with infants without surgical NEC.<\/jats:p><jats:p>\n            Conclusion\u2003Infants with surgical NEC, especially early surgical NEC, are at higher risk of ROP and severe ROP.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1733785","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T22:46:30Z","timestamp":1628030790000},"page":"1178-1184","source":"Crossref","is-referenced-by-count":25,"title":["Association of Surgical Necrotizing Enterocolitis and Its Timing with Retinopathy of Prematurity"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3531-0239","authenticated-orcid":false,"given":"Jennifer B.","family":"Fundora","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Binenbaum","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Center for Preventative Ophthalmology and Biostatistics, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-shuang","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Center for Preventative Ophthalmology and Biostatistics, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Global Newborn Society, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Donohue","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jpedsurg.2017.10.029","article-title":"Severe neurodevelopmental disability and healthcare needs among survivors of medical and surgical necrotizing enterocolitis: A prospective cohort study","volume":"53","author":"B S Fullerton","year":"2017","journal-title":"J Pediatr Surg"},{"issue":"09","key":"ref2","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/sj.jp.7211165","article-title":"Necrotizing enterocolitis and neurodevelopmental outcome in extremely low birth weight infants <1000\u2009g","volume":"24","author":"W A Salhab","year":"2004","journal-title":"J Perinatol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/1573396315666190312093119","article-title":"Necrotizing enterocolitis: long term complications","volume":"15","author":"C Bazacliu","year":"2019","journal-title":"Curr Pediatr Rev"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. 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