{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:37:15Z","timestamp":1778056635261,"version":"3.51.4"},"reference-count":70,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Corticosteroids have been used for decades in the adjunctive treatment of severe infections in intensive care. The most frequent scenario in intensive care is in septic shock, where low doses of glucocorticoids appear to restore vascular responsiveness to norepinephrine. There is a strong body of evidence suggesting that hydrocortisone reduces time on vasopressor, and may modulate the immune response. In this review, we explore the current evidence supporting the use of corticosteroids in septic shock, its benefits, and potential harms. In addition to landmark clinical trials, we will also describe new frontiers for the use of corticosteroids in septic shock which should be explored in future studies.<\/jats:p>","DOI":"10.1055\/s-0041-1733900","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T22:39:12Z","timestamp":1632177552000},"page":"726-734","source":"Crossref","is-referenced-by-count":8,"title":["What Is the Role of Steroids for Septic Shock in 2021?"],"prefix":"10.1055","volume":"42","author":[{"given":"Wagner","family":"Nedel","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"},{"name":"Intensive Care Unit, Grupo Hospitalar Concei\u00e7\u00e3o, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"Lisboa","sequence":"additional","affiliation":[{"name":"Critical Care Department, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ciencias Pneumologicas, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade e Desenvolvimento Humano, Universidade Unilasalle, Canoas, Brazil"},{"name":"Instituto de Pesquisa, HCOR, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge I.F.","family":"Salluh","sequence":"additional","affiliation":[{"name":"Department of Critical Care and Postgraduate Program in Translational Medicine, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Cl\u00ednica M\u00e9dica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 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