{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:57:13Z","timestamp":1790769433088,"version":"4.1.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"name":"National Institutes of Health (NIH)\/National Institute of Neurological Disorders and Stroke","award":["K23 NS111086"],"award-info":[{"award-number":["K23 NS111086"]}]},{"DOI":"10.13039\/100009633","name":"NIH\/NICHD","doi-asserted-by":"crossref","award":["R01 HD072071"],"award-info":[{"award-number":["R01 HD072071"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Virginia Brain Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n            Objective\u2003Severe intraventricular hemorrhage (sIVH, grades 3 and 4) is a serious complication for very low birth weight (VLBW) infants and is often clinically silent requiring screening cranial ultrasound (cUS) for detection. Abnormal vital sign (VS) patterns might serve as biomarkers to identify risk or occurrence of sIVH.<\/jats:p><jats:p>\n            Study Design\u2003This retrospective study was conducted in VLBW infants admitted to two level-IV neonatal intensive care units (NICUs) between January 2009 and December 2018. Inclusion criteria were: birth weight &lt;1.5\u2009kg and gestational age (GA) &lt;32 weeks, at least 12\u2009hours of systemic oxygen saturation from pulse oximetry (SpO2) data over the first 24\u2009hours and cUS imaging. Infants were categorized as early sIVH (sIVH identified in the first 48\u2009hours), late sIVH (sIVH identified after 48\u2009hours and normal imaging in the first 48\u2009hours), and no IVH. Infants with grades 1 and 2 or unknown timing IVH were excluded. Mean heart rate (HR), SpO2, mean arterial blood pressure (MABP), number of episodes of bradycardia (HR\u2009&lt;\u2009100\u2009bpm), and desaturation (SpO2\u2009&lt;\u200980%) were compared.<\/jats:p><jats:p>\n            Results\u2003A total of 639 infants (mean: 27 weeks' gestation) were included (567 no IVH, 34 early sIVH, and 37 late sIVH). In the first 48\u2009hours, those with sIVH had significantly higher HR compared with those with no IVH. Infants with sIVH also had lower mean SpO2 and MABP and more desaturations &lt;80%. No significant differences in VS patterns were identified in early versus late sIVH. Logistic regression identified higher HR and greater number of desaturations &lt;80% as independently associated with sIVH.<\/jats:p><jats:p>\n            Conclusion\u2003VLBW infants who develop sIVH demonstrate VS differences with significantly lower SpO2 and higher mean HR over the first 48\u2009hours after birth compared with VLBW infants with no IVH. Abnormalities in early VS patterns may be a useful biomarker for sIVH. Whether VS abnormalities predict or simply reflect sIVH remains to be determined.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1733955","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T22:57:01Z","timestamp":1630105021000},"page":"1193-1201","source":"Crossref","is-referenced-by-count":10,"title":["Early Vital Sign Differences in Very Low Birth Weight Infants with Severe Intraventricular Hemorrhage"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-7043","authenticated-orcid":false,"given":"Santina A.","family":"Zanelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Abubakar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Andris","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Patwardhan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Newborn Medicine, Washington University, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen D.","family":"Fairchild","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Vesoulis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Newborn Medicine, Washington University, St. Louis, 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