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As active participants in these physiological processes, platelets become involved in signaling pathways and pathological reactions that contribute to diseases that are defined by inflammation (including by pathogen-derived stimuli), vascular dysfunction, and coagulation. These diseases include Alzheimer's and Parkinson's disease, the two most common neurodegenerative diseases. Despite their unique pathological and clinical features, significant shared pathological processes exist between these two conditions, particularly relating to a central inflammatory mechanism involving both neuroinflammation and inflammation in the systemic environment, but also neurovascular dysfunction and coagulopathy, processes which also share initiation factors and receptors. This triad of dysfunction\u2014(neuro)inflammation, neurovascular dysfunction, and hypercoagulation\u2014illustrates the important roles platelets play in neuropathology. Although some mechanisms are understudied in Alzheimer's and Parkinson's disease, a strong case can be made for the relevance of platelets in neurodegeneration-related processes.<\/jats:p>","DOI":"10.1055\/s-0041-1733960","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:33:35Z","timestamp":1633826015000},"page":"382-404","source":"Crossref","is-referenced-by-count":5,"title":["Platelet Behavior Contributes to Neuropathologies: A Focus on Alzheimer's and Parkinson's Disease"],"prefix":"10.1055","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2479-9182","authenticated-orcid":false,"given":"Martin J.","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, Private Bag X1 Matieland, South 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Mielke","year":"2007","journal-title":"Neurology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3389\/fneur.2018.00162","article-title":"Hypertension and diagnosis of Parkinson's disease: a meta-analysis of cohort studies","volume":"9","author":"L Hou","year":"2018","journal-title":"Front Neurol"},{"issue":"02","key":"ref54","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3233\/JAD-140666","article-title":"Association between stroke and Alzheimer's disease: systematic review and meta-analysis","volume":"43","author":"J Zhou","year":"2015","journal-title":"J Alzheimers Dis"},{"issue":"08","key":"ref55","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s12031-020-01524-9","article-title":"Association between stroke and Parkinson's disease: a meta-analysis","volume":"70","author":"Y Liu","year":"2020","journal-title":"J Mol Neurosci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neubiorev.2016.03.005","article-title":"Diabetes and Alzheimer's disease crosstalk","volume":"64","author":"D Baglietto-Vargas","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"issue":"02","key":"ref57","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1212\/WNL.0000000000005771","article-title":"Association between diabetes and subsequent Parkinson disease: a record-linkage cohort study","volume":"91","author":"E De Pablo-Fernandez","year":"2018","journal-title":"Neurology"},{"issue":"04","key":"ref58","doi-asserted-by":"crossref","first-page":"e01601","DOI":"10.1002\/brb3.1601","article-title":"Association between atherosclerosis and Alzheimer's disease: a systematic review and meta-analysis","volume":"10","author":"B Xie","year":"2020","journal-title":"Brain Behav"},{"issue":"09","key":"ref59","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1182\/bloodadvances.2018017798","article-title":"Abnormal clotting of the intrinsic\/contact pathway in Alzheimer disease patients is related to cognitive ability","volume":"2","author":"G L Suidan","year":"2018","journal-title":"Blood Adv"},{"issue":"01","key":"ref60","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3233\/JAD-200358","article-title":"Increased levels of coagulation factor XI in plasma are related to Alzheimer's disease diagnosis","volume":"77","author":"E Begic","year":"2020","journal-title":"J Alzheimers Dis"},{"issue":"05","key":"ref61","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/jth.13209","article-title":"The Alzheimer's disease peptide \u03b2-amyloid promotes thrombin generation through activation of coagulation factor XII","volume":"14","author":"D Zamolodchikov","year":"2016","journal-title":"J Thromb 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04","key":"ref68","doi-asserted-by":"crossref","first-page":"S537","DOI":"10.3233\/JAD-141557","article-title":"Targeting thrombin: an inflammatory neurotoxin in Alzheimer's disease","volume":"42","author":"P Grammas","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3389\/fimmu.2018.01731","article-title":"The coagulation factors fibrinogen, thrombin, and factor XII in inflammatory disorders\u2014a systematic review","volume":"9","author":"K G\u00f6bel","year":"2018","journal-title":"Front Immunol"},{"issue":"04","key":"ref70","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3233\/JAD-200610","article-title":"Anticoagulants for treatment of Alzheimer's disease","volume":"77","author":"K Grossmann","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0022-510X(03)00101-1","article-title":"Coagulation-fibrinolysis abnormalities 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Leiter","year":"2020","journal-title":"Front Immunol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"101695","DOI":"10.1016\/j.pneurobio.2019.101695","article-title":"Platelets: the missing link between the blood and brain?","volume":"183","author":"O Leiter","year":"2019","journal-title":"Prog Neurobiol"},{"issue":"02","key":"ref79","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3390\/jcm8020162","article-title":"Platelet depletion is effective in ameliorating anxiety-like behavior and reducing the pro-inflammatory environment in the hippocampus in murine experimental autoimmune encephalomyelitis","volume":"8","author":"P Kocovski","year":"2019","journal-title":"J Clin Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.expneurol.2015.03.018","article-title":"Lesion-induced accumulation of platelets promotes survival of adult neural stem \/ progenitor cells","volume":"269","author":"I Kazanis","year":"2015","journal-title":"Exp Neurol"},{"issue":"01","key":"ref81","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1567202612666150102124703","article-title":"Platelets in the Alzheimer's disease brain: do they play a role in cerebral amyloid angiopathy?","volume":"12","author":"K M Kniewallner","year":"2015","journal-title":"Curr Neurovasc Res"},{"issue":"09","key":"ref82","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.cellsig.2014.05.019","article-title":"Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease","volume":"26","author":"A Jarre","year":"2014","journal-title":"Cell Signal"},{"issue":"04","key":"ref83","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archneur.55.4.530","article-title":"Platelet activation in Alzheimer disease","volume":"55","author":"S Sevush","year":"1998","journal-title":"Arch Neurol"},{"issue":"12","key":"ref84","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.cellsig.2016.08.017","article-title":"Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease","volume":"28","author":"I Canobbio","year":"2016","journal-title":"Cell Signal"},{"issue":"03","key":"ref85","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.trsl.2008.07.001","article-title":"Rate of progression in Alzheimer's disease correlates with coated-platelet levels\u2013a longitudinal study","volume":"152","author":"C I Prodan","year":"2008","journal-title":"Transl Res"},{"issue":"03","key":"ref86","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1212\/WNL.0b013e3182074bd2","article-title":"Coated-platelet levels and progression from mild cognitive impairment to Alzheimer disease","volume":"76","author":"C I Prodan","year":"2011","journal-title":"Neurology"},{"issue":"34","key":"ref87","doi-asserted-by":"crossref","first-page":"35284","DOI":"10.18632\/oncotarget.6074","article-title":"Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)","volume":"6","author":"J Bester","year":"2015","journal-title":"Oncotarget"},{"issue":"03","key":"ref88","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neurobiolaging.2005.12.011","article-title":"Determinants of platelet activation in Alzheimer's disease","volume":"28","author":"G Ciabattoni","year":"2007","journal-title":"Neurobiol Aging"},{"issue":"16","key":"ref89","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/j.febslet.2013.06.041","article-title":"Immobilized amyloid A\u03b2 peptides support platelet adhesion and activation","volume":"587","author":"I Canobbio","year":"2013","journal-title":"FEBS Lett"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ejphar.2008.04.040","article-title":"Amyloid beta peptide-activated signal pathways in human platelets","volume":"588","author":"M Y Shen","year":"2008","journal-title":"Eur J Pharmacol"},{"issue":"02","key":"ref91","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.phrs.2008.01.004","article-title":"Expression of amyloid beta peptide in human platelets: pivotal role of the phospholipase Cgamma2-protein kinase C pathway in platelet activation","volume":"57","author":"M Y Shen","year":"2008","journal-title":"Pharmacol Res"},{"issue":"03","key":"ref92","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/BJ20140307","article-title":"Amyloid \u03b2-peptide-dependent activation of human platelets: essential role for Ca2+ and ADP in aggregation and thrombus formation","volume":"462","author":"I Canobbio","year":"2014","journal-title":"Biochem 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Sonkar","year":"2014","journal-title":"FASEB J"},{"issue":"643","key":"ref96","doi-asserted-by":"crossref","first-page":"eaba9872","DOI":"10.1126\/scisignal.aba9872","article-title":"The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of \u03b2-amyloid","volume":"13","author":"L Donner","year":"2020","journal-title":"Sci Signal"},{"issue":"02","key":"ref97","doi-asserted-by":"crossref","first-page":"e90523","DOI":"10.1371\/journal.pone.0090523","article-title":"Blood platelets in the progression of Alzheimer's disease","volume":"9","author":"N S Gowert","year":"2014","journal-title":"PLoS One"},{"issue":"01","key":"ref98","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/bbrc.1995.2103","article-title":"Platelets are the primary source of amyloid beta-peptide in human blood","volume":"213","author":"M Chen","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"issue":"01","key":"ref99","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1182\/blood.V84.1.133.133","article-title":"Membrane-associated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelet and brain: surface expression on the activated human platelet","volume":"84","author":"Q X Li","year":"1994","journal-title":"Blood"},{"issue":"03","key":"ref100","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1212\/01.WNL.0000106953.49802.9C","article-title":"Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease","volume":"62","author":"F Colciaghi","year":"2004","journal-title":"Neurology"},{"issue":"05","key":"ref101","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.neurobiolaging.2006.11.003","article-title":"Platelet beta-secretase activity is increased in Alzheimer's disease","volume":"29","author":"J A Johnston","year":"2008","journal-title":"Neurobiol Aging"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000345983","article-title":"ADAM10 as a biomarker for Alzheimer's disease: a study with Brazilian elderly","volume":"35","author":"P R Manzine","year":"2013","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"01","key":"ref103","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/09537100802334434","article-title":"Platelet alpha- and beta-secretase activities: a preliminary study in normal human subjects","volume":"20","author":"C C Smith","year":"2009","journal-title":"Platelets"},{"issue":"10","key":"ref104","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.neurobiolaging.2007.12.009","article-title":"Differential processing and secretion of Abeta peptides and sAPPalpha in human platelets is regulated by thrombin and prostaglandine 2","volume":"30","author":"A Smirnov","year":"2009","journal-title":"Neurobiol Aging"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neuroscience.2018.11.025","article-title":"The cAMP\/PKA pathway inhibits beta-amyloid peptide release from human platelets","volume":"397","author":"C Sep\u00falveda","year":"2019","journal-title":"Neuroscience"},{"issue":"04","key":"ref106","first-page":"461","article-title":"Secretion of Alzheimer's disease Abeta amyloid peptide by activated human platelets","volume":"78","author":"Q X Li","year":"1998","journal-title":"Lab Invest"},{"issue":"26","key":"ref107","doi-asserted-by":"crossref","first-page":"15977","DOI":"10.1016\/S0021-9258(18)55493-4","article-title":"The amyloid precursor protein of Alzheimer's disease is released by human platelets","volume":"265","author":"A I Bush","year":"1990","journal-title":"J Biol Chem"},{"issue":"09","key":"ref108","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1038\/mp.2017.204","article-title":"Blood-derived amyloid-\u03b2 protein induces Alzheimer's disease pathologies","volume":"23","author":"X L Bu","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"01","key":"ref109","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1742-4933-9-20","article-title":"Alzheimer disease and platelets: how's that relevant","volume":"9","author":"S Catricala","year":"2012","journal-title":"Immun Ageing"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/2051-5960-2-65","article-title":"Platelets, a reliable source for peripheral Alzheimer's disease biomarkers?","volume":"2","author":"M Veitinger","year":"2014","journal-title":"Acta Neuropathol Commun"},{"issue":"01","key":"ref111","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0022-510X(94)90056-6","article-title":"Platelet morphology in Parkinson's disease: an electron microscopic study","volume":"122","author":"S A Factor","year":"1994","journal-title":"J Neurol Sci"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"986254","DOI":"10.1155\/2013\/986254","article-title":"Assessment of platelet indices in patients with neurodegenerative diseases: mean platelet volume was increased in patients with Parkinson's disease","volume":"2013","author":"A Ko\u00e7er","year":"2013","journal-title":"Curr Gerontol Geriatr Res"},{"issue":"12","key":"ref113","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1161\/01.STR.22.12.1607","article-title":"Platelet aggregation in patients with Parkinson's disease","volume":"22","author":"P Sharma","year":"1991","journal-title":"Stroke"},{"issue":"03","key":"ref114","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/09537100902721746","article-title":"Inhibition of platelet aggregation by 1-methyl-4-phenyl pyridinium ion (MPP+) through ATP depletion: evidence for the reduced platelet activities in Parkinson's disease","volume":"20","author":"K M Lim","year":"2009","journal-title":"Platelets"},{"issue":"04","key":"ref115","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3233\/JAD-2002-4406","article-title":"Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects","volume":"4","author":"Q X Li","year":"2002","journal-title":"J Alzheimers Dis"},{"issue":"07","key":"ref116","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1182\/blood.V100.7.2506","article-title":"Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets","volume":"100","author":"S M Park","year":"2002","journal-title":"Blood"},{"issue":"10","key":"ref117","doi-asserted-by":"crossref","first-page":"788","DOI":"10.18632\/aging.100695","article-title":"Eryptosis as a marker of Parkinson's disease","volume":"6","author":"E Pretorius","year":"2014","journal-title":"Aging (Albany NY)"},{"issue":"173","key":"ref118","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3389\/fimmu.2019.01731","article-title":"Platelets and immune responses during thromboinflammation","volume":"10","author":"M Mezger","year":"2019","journal-title":"Rev Front Immunol"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3389\/fimmu.2019.01320","article-title":"Regulation of innate immune responses by platelets","volume":"10","author":"L S Ribeiro","year":"2019","journal-title":"Front Immunol"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"548631","DOI":"10.3389\/fimmu.2020.548631","article-title":"Platelets as mediators of neuroinflammation and thrombosis","volume":"11","author":"E Rawish","year":"2020","journal-title":"Front Immunol"},{"issue":"03","key":"ref121","doi-asserted-by":"crossref","first-page":"e58979","DOI":"10.1371\/journal.pone.0058979","article-title":"Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation","volume":"8","author":"I Sotnikov","year":"2013","journal-title":"PLoS One"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbi.2016.09.021","article-title":"Platelet CD40L induces activation of astrocytes and microglia in hypertension","volume":"59","author":"S A Bhat","year":"2017","journal-title":"Brain Behav Immun"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bbi.2018.09.009","article-title":"Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury","volume":"74","author":"M Dukhinova","year":"2018","journal-title":"Brain Behav Immun"},{"issue":"10","key":"ref124","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/jnnp-2017-316201","article-title":"Peripheral inflammatory markers in Alzheimer's disease: a systematic review and meta-analysis of 175 studies","volume":"88","author":"K SP Lai","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"05","key":"ref125","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/jnnp-2018-319148","article-title":"Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies","volume":"90","author":"X N Shen","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"ref126","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1001\/jamaneurol.2016.2742","article-title":"Aberrations in peripheral inflammatory cytokine levels in Parkinson disease: a systematic review and meta-analysis","volume":"73","author":"X Y Qin","year":"2016","journal-title":"JAMA Neurol"},{"issue":"11","key":"ref127","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/s41590-018-0232-x","article-title":"Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration","volume":"19","author":"J K Ryu","year":"2018","journal-title":"Nat Immunol"},{"issue":"04","key":"ref128","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1074\/jbc.M113.518126","article-title":"The interaction of integrin \u03b1IIb\u03b23 with fibrin occurs through multiple binding sites in the \u03b1IIb \u03b2-propeller domain","volume":"289","author":"N P Podolnikova","year":"2014","journal-title":"J Biol Chem"},{"issue":"07","key":"ref129","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1182\/blood-2008-02-142125","article-title":"Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets","volume":"112","author":"B Boylan","year":"2008","journal-title":"Blood"},{"issue":"05","key":"ref130","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood-2015-02-629717","article-title":"Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation","volume":"126","author":"E Mammadova-Bach","year":"2015","journal-title":"Blood"},{"issue":"13","key":"ref131","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1182\/blood-2015-04-641654","article-title":"Fibrin activates GPVI in human and mouse platelets","volume":"126","author":"O M Alshehri","year":"2015","journal-title":"Blood"},{"issue":"02","key":"ref132","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1189\/jlb.0708400","article-title":"Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases","volume":"85","author":"J M van Gils","year":"2009","journal-title":"J Leukoc Biol"},{"issue":"10","key":"ref133","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.4049\/jimmunol.1300354","article-title":"Lipopolysaccharide stimulates platelets through an IL-1\u03b2 autocrine loop","volume":"191","author":"G T Brown","year":"2013","journal-title":"J Immunol"},{"issue":"04","key":"ref134","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/cvr\/cvw162","article-title":"Expression and function of IL-1R8 (TIR8\/SIGIRR): a regulatory member of the IL-1 receptor family in platelets","volume":"111","author":"A Anselmo","year":"2016","journal-title":"Cardiovasc Res"},{"issue":"20","key":"ref135","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1182\/blood-2013-05-504449","article-title":"Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation","volume":"122","author":"E D Hottz","year":"2013","journal-title":"Blood"},{"issue":"01","key":"ref136","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbrc.2016.12.161","article-title":"The NLRP3 inflammasome and bruton's tyrosine kinase in platelets co-regulate platelet activation, aggregation, and in vitro thrombus formation","volume":"483","author":"P Murthy","year":"2017","journal-title":"Biochem Biophys Res 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Haemost"},{"issue":"07","key":"ref143","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/jth.12612","article-title":"Platelets provoke distinct dynamics of immune responses by differentially regulating CD4+ T-cell proliferation","volume":"12","author":"L Zhu","year":"2014","journal-title":"J Thromb Haemost"},{"issue":"16","key":"ref144","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1182\/blood-2015-04-640300","article-title":"Platelet microparticles inhibit IL-17 production by regulatory T cells through P-selectin","volume":"127","author":"S Dinkla","year":"2016","journal-title":"Blood"},{"issue":"04","key":"ref145","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bbrc.2011.04.080","article-title":"IL-17A increases ADP-induced platelet aggregation","volume":"408","author":"F Maione","year":"2011","journal-title":"Biochem Biophys Res 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Sci"},{"issue":"01","key":"ref149","doi-asserted-by":"crossref","first-page":"15483","DOI":"10.1038\/s41598-018-33768-2","article-title":"Platelets isolated from an Alzheimer mouse damage healthy cortical vessels and cause inflammation in an organotypic ex vivo brain slice model","volume":"8","author":"K M Kniewallner","year":"2018","journal-title":"Sci Rep"},{"issue":"08","key":"ref150","doi-asserted-by":"crossref","first-page":"982","DOI":"10.2174\/156720512803251156","article-title":"Matrix metalloproteinase-2 and epidermal growth factor are decreased in platelets of Alzheimer patients","volume":"9","author":"T Hochstrasser","year":"2012","journal-title":"Curr Alzheimer Res"},{"issue":"07","key":"ref151","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/sj.bjp.0705997","article-title":"Platelet-leukocyte aggregation induced by PAR agonists: regulation by nitric oxide and matrix metalloproteinases","volume":"143","author":"A W Chung","year":"2004","journal-title":"Br J Pharmacol"},{"issue":"06","key":"ref152","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1055\/s-0037-1614906","article-title":"Differential regulation of platelet aggregation by matrix metalloproteinases-9 and -2","volume":"82","author":"C Fernandez-Patron","year":"1999","journal-title":"Thromb Haemost"},{"issue":"03","key":"ref153","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1538-7836.2007.02871.x","article-title":"MMP-2 regulates human platelet activation by interacting with integrin alphaIIbbeta3","volume":"6","author":"W S Choi","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"05","key":"ref154","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/sj.bjp.0704345","article-title":"Pharmacological characteristics of solid-phase von Willebrand factor in human platelets","volume":"134","author":"A Radomski","year":"2001","journal-title":"Br J Pharmacol"},{"issue":"01","key":"ref155","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1160\/TH13-03-0248","article-title":"Intracellular matrix metalloproteinase-2 (MMP-2) regulates human platelet activation via hydrolysis of talin","volume":"111","author":"G Soslau","year":"2014","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref156","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/j.1538-7836.2010.03837.x","article-title":"CD40 ligand shedding is regulated by interaction between matrix metalloproteinase-2 and platelet integrin alpha(IIb)beta(3)","volume":"8","author":"W S Choi","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"07","key":"ref157","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1182\/blood-2016-06-724245","article-title":"A novel mechanism regulating human platelet activation by MMP-2-mediated PAR1 biased signaling","volume":"129","author":"M Sebastiano","year":"2017","journal-title":"Blood"},{"issue":"02","key":"ref158","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cell.2009.02.018","article-title":"Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site","volume":"137","author":"V Trivedi","year":"2009","journal-title":"Cell"},{"issue":"01","key":"ref159","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/sj.bjp.0705917","article-title":"Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies","volume":"143","author":"J R Sheu","year":"2004","journal-title":"Br J Pharmacol"},{"key":"ref160","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2006.03.031","article-title":"Inhibitory mechanisms of activated matrix metalloproteinase-9 on platelet activation","volume":"537","author":"Y M Lee","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbi.2019.06.042","article-title":"Toll-like receptors and their therapeutic potential in Parkinson's disease and \u03b1-synucleinopathies","volume":"81","author":"A Kouli","year":"2019","journal-title":"Brain Behav Immun"},{"key":"ref162","doi-asserted-by":"crossref","first-page":"577362","DOI":"10.1016\/j.jneuroim.2020.577362","article-title":"Toll-like receptors in Alzheimer's disease","volume":"348","author":"S Momtazmanesh","year":"2020","journal-title":"J Neuroimmunol"},{"issue":"09","key":"ref163","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.3390\/ijms19092603","article-title":"Heat shock proteins in Alzheimer's disease: role and targeting","volume":"19","author":"C Campanella","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"03","key":"ref164","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/jnc.14450","article-title":"High-mobility group box 1 in Parkinson's disease: from pathogenesis to therapeutic approaches","volume":"146","author":"E Angelopoulou","year":"2018","journal-title":"J Neurochem"},{"issue":"02","key":"ref165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/cells9020383","article-title":"Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): from risk factors to therapeutic targeting","volume":"9","author":"Y N Paudel","year":"2020","journal-title":"Cells"},{"key":"ref166","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fimmu.2015.00083","article-title":"The inflammatory role of platelets via their TLRs and Siglec receptors","volume":"6","author":"F Cognasse","year":"2015","journal-title":"Front Immunol"},{"issue":"04","key":"ref167","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"S R Clark","year":"2007","journal-title":"Nat Med"},{"issue":"01","key":"ref168","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2141.2008.06999.x","article-title":"Toll-like receptor 4 ligand can differentially modulate the release of cytokines by human platelets","volume":"141","author":"F Cognasse","year":"2008","journal-title":"Br J Haematol"},{"issue":"03","key":"ref169","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.clim.2012.09.004","article-title":"Human platelets can discriminate between various bacterial LPS isoforms via TLR4 signaling and differential cytokine secretion","volume":"145","author":"J Berthet","year":"2012","journal-title":"Clin Immunol"},{"issue":"02","key":"ref170","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s00134-006-0488-8","article-title":"Lipopolysaccharide induces sCD40L release through human platelets TLR4, but not TLR2 and TLR9","volume":"33","author":"F Cognasse","year":"2007","journal-title":"Intensive Care Med"},{"issue":"03","key":"ref171","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.thromres.2012.04.017","article-title":"Periodontopathogens induce expression of CD40L on human platelets via TLR2 and TLR4","volume":"130","author":"A Assinger","year":"2012","journal-title":"Thromb Res"},{"key":"ref172","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.atherosclerosis.2019.12.017","article-title":"Internalization of microparticles by platelets is partially mediated by toll-like receptor 4 and enhances platelet thrombogenicity","volume":"294","author":"D Jerez-Dolz","year":"2020","journal-title":"Atherosclerosis"},{"issue":"17","key":"ref173","doi-asserted-by":"crossref","first-page":"6150","DOI":"10.3390\/ijms21176150","article-title":"Revisiting platelets and toll-like receptors (TLRs): at the interface of vascular immunity and thrombosis","volume":"21","author":"K Hally","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref174","doi-asserted-by":"crossref","first-page":"1179573517709278","DOI":"10.1177\/1179573517709278","article-title":"Tumor necrosis factor \u03b1 inhibition for Alzheimer's disease","volume":"9","author":"R Chang","year":"2017","journal-title":"J Cent Nerv Syst Dis"},{"issue":"08","key":"ref175","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1136\/annrheumdis-2015-208442","article-title":"Anti-TNF\u03b1 agents curb platelet activation in patients with rheumatoid arthritis","volume":"75","author":"A A Manfredi","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"01","key":"ref176","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1038\/s41598-018-20220-8","article-title":"The inflammatory effects of TNF-\u03b1 and complement component 3 on coagulation","volume":"8","author":"M J Page","year":"2018","journal-title":"Sci Rep"},{"issue":"06","key":"ref177","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1182\/blood-2005-03-1247","article-title":"Tumor necrosis factor-alpha as trigger of platelet activation in patients with heart failure","volume":"106","author":"P Pignatelli","year":"2005","journal-title":"Blood"},{"issue":"03","key":"ref178","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/cvr\/cvn040","article-title":"Tumour necrosis factor alpha upregulates platelet CD40L in patients with heart failure","volume":"78","author":"P Pignatelli","year":"2008","journal-title":"Cardiovasc Res"},{"issue":"08","key":"ref179","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1080\/09537104.2019.1588241","article-title":"Tumor necrosis factor alpha has a crucial role in increased reactive oxygen species production in platelets of mice injected with lipopolysaccharide","volume":"30","author":"A CA Naime","year":"2019","journal-title":"Platelets"},{"issue":"05","key":"ref180","doi-asserted-by":"crossref","first-page":"R225","DOI":"10.1186\/ar4064","article-title":"Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2","volume":"14","author":"J Pircher","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.thromres.2018.10.008","article-title":"Platelet activity is negatively modulated by tumor necrosis factor alpha through reductions of cytosolic calcium levels and integrin alphaIIbbeta3 phosphorylation","volume":"172","author":"P HL Bonfitto","year":"2018","journal-title":"Thromb Res"},{"issue":"09","key":"ref182","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1182\/blood.2019000200","article-title":"TNF-\u03b1-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging","volume":"134","author":"P Davizon-Castillo","year":"2019","journal-title":"Blood"},{"key":"ref183","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3389\/fimmu.2014.00649","article-title":"Platelets and infection\u2014an emerging role of platelets in viral infection","volume":"5","author":"A Assinger","year":"2014","journal-title":"Front Immunol"},{"issue":"82","key":"ref184","first-page":"82","article-title":"Platelets and infections\u2014complex interactions with bacteria","volume":"6","author":"H Hamzeh-Cognasse","year":"2015","journal-title":"Rev Front Immunol"},{"key":"ref185","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fmed.2018.00121","article-title":"Platelets in immune response to virus and immunopathology of viral infections","volume":"5","author":"E D Hottz","year":"2018","journal-title":"Front Med (Lausanne)"},{"issue":"06","key":"ref186","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrmicro3269","article-title":"Platelets: at the nexus of antimicrobial defence","volume":"12","author":"M R Yeaman","year":"2014","journal-title":"Nat Rev Microbiol"},{"issue":"03","key":"ref187","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1055\/s-0040-1708827","article-title":"A champion of host defense: a generic large-scale cause for platelet dysfunction and depletion in infection","volume":"46","author":"M J Page","year":"2020","journal-title":"Semin Thromb Hemost"},{"issue":"08","key":"ref188","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.2631","article-title":"Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance","volume":"14","author":"C H Wong","year":"2013","journal-title":"Nat Immunol"},{"issue":"12","key":"ref189","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/ni.2140","article-title":"A platelet-mediated system for shuttling blood-borne bacteria to CD8\u03b1+ dendritic cells depends on glycoprotein GPIb and complement C3","volume":"12","author":"A Verschoor","year":"2011","journal-title":"Nat Immunol"},{"key":"ref190","doi-asserted-by":"crossref","first-page":"571083","DOI":"10.3389\/fimmu.2020.571083","article-title":"On the role of platelet-generated amyloid beta peptides in certain amyloidosis health complications","volume":"11","author":"M Inyushin","year":"2020","journal-title":"Front Immunol"},{"issue":"11","key":"ref191","doi-asserted-by":"crossref","first-page":"e0186981","DOI":"10.1371\/journal.pone.0186981","article-title":"Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling","volume":"12","author":"M E Lopes Pires","year":"2017","journal-title":"PLoS One"},{"key":"ref192","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cellimm.2018.04.002","article-title":"LPS enhances platelets aggregation via TLR4, which is related to mitochondria damage caused by intracellular ROS, but not extracellular ROS","volume":"328","author":"G Feng","year":"2018","journal-title":"Cell Immunol"},{"issue":"12","key":"ref193","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1182\/blood.V97.12.3790","article-title":"Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity","volume":"97","author":"A Lourbakos","year":"2001","journal-title":"Blood"},{"issue":"01","key":"ref194","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/09537100120104863","article-title":"Aggregation of human platelets by gingipain-R from Porphyromonas gingivalis cells and membrane vesicles","volume":"13","author":"K Pham","year":"2002","journal-title":"Platelets"},{"issue":"01","key":"ref195","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/omi.12067","article-title":"The role of Porphyromonas gingivalis gingipains in platelet activation and innate immune modulation","volume":"30","author":"K Klarstr\u00f6m Engstr\u00f6m","year":"2015","journal-title":"Mol Oral Microbiol"},{"issue":"17","key":"ref196","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1182\/blood-2009-11-252643","article-title":"Platelet interleukin-1alpha drives cerebrovascular inflammation","volume":"115","author":"P Thornton","year":"2010","journal-title":"Blood"},{"issue":"02","key":"ref197","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/imm.12892","article-title":"Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIb\u03b1","volume":"154","author":"J A Giles","year":"2018","journal-title":"Immunology"},{"key":"ref198","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.1256478","article-title":"Neutrophils scan for activated platelets to initiate inflammation","volume":"346","author":"V Sreeramkumar","year":"2014","journal-title":"Science"},{"issue":"33","key":"ref199","doi-asserted-by":"crossref","first-page":"E4847","DOI":"10.1073\/pnas.1607710113","article-title":"CCN1\/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation","volume":"113","author":"B A Imhof","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref200","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jneuroim.2010.08.015","article-title":"Platelet activating factor induces blood brain barrier permeability alteration in vitro","volume":"230","author":"W Fang","year":"2011","journal-title":"J Neuroimmunol"},{"issue":"05","key":"ref201","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/jnc.12507","article-title":"Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain","volume":"128","author":"W Fang","year":"2014","journal-title":"J Neurochem"},{"issue":"02","key":"ref202","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/jnc.14983","article-title":"Platelet regulates neuroinflammation and restores blood-brain barrier integrity in a mouse model of traumatic brain injury","volume":"154","author":"C Gao","year":"2020","journal-title":"J Neurochem"},{"key":"ref203","doi-asserted-by":"crossref","first-page":"28447","DOI":"10.1038\/srep28447","article-title":"Thiazine Red(+) platelet inclusions in cerebral blood vessels are first signs in an Alzheimer's Disease mouse model","volume":"6","author":"K M Kniewallner","year":"2016","journal-title":"Sci Rep"},{"key":"ref204","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.brainresbull.2016.11.008","article-title":"Platelets are responsible for the accumulation of \u03b2-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis","volume":"128","author":"L Y Kucheryavykh","year":"2017","journal-title":"Brain Res Bull"},{"issue":"04","key":"ref205","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0022-2143(98)90048-8","article-title":"Brain endothelial cell enzymes cleave platelet-retained amyloid precursor protein","volume":"132","author":"T A Davies","year":"1998","journal-title":"J Lab Clin Med"},{"issue":"12","key":"ref206","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1182\/blood-2009-05-199208","article-title":"Coagulation and innate immune responses: can we view them separately?","volume":"114","author":"M Delvaeye","year":"2009","journal-title":"Blood"},{"issue":"04","key":"ref207","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1182\/blood-2017-01-764910","article-title":"Platelet amyloid precursor protein is a modulator of venous thromboembolism in mice","volume":"130","author":"I Canobbio","year":"2017","journal-title":"Blood"},{"issue":"50","key":"ref208","doi-asserted-by":"crossref","first-page":"18135","DOI":"10.1073\/pnas.0507798102","article-title":"Protease nexin-2\/amyloid beta-protein precursor limits cerebral thrombosis","volume":"102","author":"F Xu","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"46","key":"ref209","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1021\/acs.biochem.0c00450","article-title":"Post-translational modifications of platelet-derived amyloid precursor protein by coagulation factor XIII-A","volume":"59","author":"W S Hur","year":"2020","journal-title":"Biochemistry"},{"issue":"08","key":"ref210","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/acn3.79","article-title":"Phosphodiesterase III inhibitor promotes drainage of cerebrovascular \u03b2-amyloid","volume":"1","author":"T Maki","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"issue":"04","key":"ref211","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/JGP.0b013e31819431ea","article-title":"A combination therapy of donepezil and cilostazol for patients with moderate Alzheimer disease: pilot follow-up study","volume":"17","author":"H Arai","year":"2009","journal-title":"Am J Geriatr Psychiatry"},{"issue":"01","key":"ref212","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1447-0594.2012.00866.x","article-title":"Effects of cilostazol on cognition and regional cerebral blood flow in patients with Alzheimer's disease and cerebrovascular disease: a pilot study","volume":"13","author":"H Sakurai","year":"2013","journal-title":"Geriatr Gerontol Int"},{"issue":"01","key":"ref213","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12883-017-0800-y","article-title":"Cilostazol as an add-on therapy for patients with Alzheimer's disease in Taiwan: a case control study","volume":"17","author":"S Y Tai","year":"2017","journal-title":"BMC Neurol"},{"issue":"04","key":"ref214","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2011.04.068","article-title":"Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid \u03b2-induced cognitive deficits associated with decreased amyloid \u03b2 accumulation","volume":"408","author":"S H Park","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"09","key":"ref215","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.1007\/s12035-018-0923-1","article-title":"Cilostazol mediated Nurr1 and autophagy enhancement: neuroprotective activity in rat rotenone PD model","volume":"55","author":"S A Hedya","year":"2018","journal-title":"Mol Neurobiol"},{"issue":"01","key":"ref216","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1474-4422(07)70293-4","article-title":"Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial","volume":"7","author":"P Bentham","year":"2008","journal-title":"Lancet Neurol"},{"issue":"03","key":"ref217","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.3233\/JAD-160013","article-title":"Influence of low-dose aspirin on cerebral amyloid angiopathy in mice","volume":"52","author":"Y Hattori","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"20","key":"ref218","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1074\/jbc.M006285200","article-title":"Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C","volume":"276","author":"D M Skovronsky","year":"2001","journal-title":"J Biol Chem"},{"issue":"15","key":"ref219","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1097\/00001756-200110290-00024","article-title":"Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation","volume":"12","author":"T Thomas","year":"2001","journal-title":"Neuroreport"},{"issue":"30","key":"ref220","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1523\/JNEUROSCI.0054-18.2018","article-title":"Aspirin induces lysosomal biogenesis and attenuates amyloid plaque pathology in a mouse model of Alzheimer's disease via PPAR\u03b1","volume":"38","author":"S Chandra","year":"2018","journal-title":"J Neurosci"},{"issue":"31","key":"ref221","doi-asserted-by":"crossref","first-page":"E7408","DOI":"10.1073\/pnas.1802021115","article-title":"Aspirin binds to PPAR\u03b1 to stimulate hippocampal plasticity and protect memory","volume":"115","author":"D Patel","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref222","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1212\/WNL.0b013e3181d5a4a3","article-title":"Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis","volume":"74","author":"J J Gagne","year":"2010","journal-title":"Neurology"},{"issue":"10","key":"ref223","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1212\/WNL.0b013e31820f2d79","article-title":"Use of ibuprofen and risk of Parkinson disease","volume":"76","author":"X Gao","year":"2011","journal-title":"Neurology"},{"issue":"02","key":"ref224","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11481-018-9808-3","article-title":"Low-dose aspirin upregulates tyrosine hydroxylase and increases dopamine production in dopaminergic neurons: implications for Parkinson's disease","volume":"14","author":"S B Rangasamy","year":"2019","journal-title":"J Neuroimmune Pharmacol"},{"issue":"10","key":"ref225","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/mds.28189","article-title":"Nonsteroidal anti-inflammatory use and LRRK2 Parkinson's disease penetrance","volume":"35","author":"M San Luciano","year":"2020","journal-title":"Mov Disord"},{"issue":"74","key":"ref226","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fcvm.2017.00074","article-title":"Platelet-derived microvesicles in cardiovascular diseases","volume":"4","author":"M TK Zaldivia","year":"2017","journal-title":"Rev Front Cardiovasc Med"},{"issue":"04","key":"ref227","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.eurger.2016.05.001","article-title":"Elevated platelet microparticles levels are associated with lipidic oxidation and inflammatory profiles in Alzheimer's disease","volume":"7","author":"G S Gon\u00e7alves","year":"2016","journal-title":"Eur Geriatr Med"},{"issue":"04","key":"ref228","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1055\/s-0038-1648906","article-title":"Amyloid beta-protein precursor-rich platelet microparticles in thrombotic disease","volume":"72","author":"S Nomura","year":"1994","journal-title":"Thromb Haemost"},{"key":"ref229","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1749-6632.2002.tb04836.x","article-title":"Platelet microparticles as carriers of soluble Alzheimer's amyloid beta (sAbeta)","volume":"977","author":"E Matsubara","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"ref230","doi-asserted-by":"crossref","first-page":"577027","DOI":"10.1016\/j.jneuroim.2019.577027","article-title":"Microparticles are related to cognitive and functional status from normal aging to dementia","volume":"336","author":"C A Magalh\u00e3es","year":"2019","journal-title":"J Neuroimmunol"},{"issue":"05","key":"ref231","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jalz.2014.06.003","article-title":"Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease","volume":"11","author":"C Laske","year":"2015","journal-title":"Alzheimers Dement"},{"issue":"01","key":"ref232","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11011-017-0149-3","article-title":"Plasma microparticles in Alzheimer's disease: the role of vascular dysfunction","volume":"33","author":"S Hosseinzadeh","year":"2018","journal-title":"Metab Brain Dis"},{"key":"ref233","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbr.2013.09.019","article-title":"Elevated CSF and plasma microparticles in a rat model of streptozotocin-induced cognitive impairment","volume":"256","author":"S Hosseinzadeh","year":"2013","journal-title":"Behav Brain Res"},{"issue":"06","key":"ref234","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.neuron.2019.01.014","article-title":"Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an Alzheimer's disease model","volume":"101","author":"M Merlini","year":"2019","journal-title":"Neuron"},{"key":"ref235","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neubiorev.2020.02.022","article-title":"Fibrinogen and risk of dementia: a systematic review and meta-analysis","volume":"112","author":"Z Zhou","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"issue":"01","key":"ref236","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000260070","article-title":"Association of fibrinogen with Parkinson disease in elderly Japanese-American men: a prospective study","volume":"34","author":"K T Wong","year":"2010","journal-title":"Neuroepidemiology"},{"issue":"04","key":"ref237","doi-asserted-by":"crossref","first-page":"e95684","DOI":"10.1371\/journal.pone.0095684","article-title":"Specific changes of serum proteins in Parkinson's disease patients","volume":"9","author":"W Lu","year":"2014","journal-title":"PLoS One"},{"issue":"07","key":"ref238","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1179\/1743132812Y.0000000063","article-title":"Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson's disease subjects","volume":"34","author":"C L Maarouf","year":"2012","journal-title":"Neurol Res"},{"issue":"08","key":"ref239","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-beta","volume":"9","author":"A Halle","year":"2008","journal-title":"Nat Immunol"},{"issue":"06","key":"ref240","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/jnc.14945","article-title":"Soluble A\u03b2 oligomers and protofibrils induce NLRP3 inflammasome activation in microglia","volume":"155","author":"A Lu\u010di\u016bnait\u0117","year":"2020","journal-title":"J Neurochem"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"M T Heneka","year":"2013","journal-title":"Nature"},{"key":"ref242","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-016-0088-1","article-title":"The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease","volume":"11","author":"M Saresella","year":"2016","journal-title":"Mol Neurodegener"},{"key":"ref243","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature25158","article-title":"Microglia-derived ASC specks cross-seed amyloid-\u03b2 in Alzheimer's disease","volume":"552","author":"C Venegas","year":"2017","journal-title":"Nature"},{"issue":"04","key":"ref244","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00401-018-01957-y","article-title":"Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo","volume":"137","author":"I C Stancu","year":"2019","journal-title":"Acta Neuropathol"},{"key":"ref245","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","article-title":"NLRP3 inflammasome activation drives tau pathology","volume":"575","author":"C Ising","year":"2019","journal-title":"Nature"},{"issue":"01","key":"ref246","doi-asserted-by":"crossref","first-page":"e55375","DOI":"10.1371\/journal.pone.0055375","article-title":"Triggering of inflammasome by aggregated \u03b1-synuclein, an inflammatory response in synucleinopathies","volume":"8","author":"G Codolo","year":"2013","journal-title":"PLoS One"},{"issue":"04","key":"ref247","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s11064-017-2185-0","article-title":"The NLRP3 inflammasome is involved in the pathogenesis of Parkinson's disease in rats","volume":"42","author":"Z Mao","year":"2017","journal-title":"Neurochem Res"},{"issue":"465","key":"ref248","doi-asserted-by":"crossref","first-page":"eaah4066","DOI":"10.1126\/scitranslmed.aah4066","article-title":"Inflammasome inhibition prevents \u03b1-synuclein pathology and dopaminergic neurodegeneration in mice","volume":"10","author":"R Gordon","year":"2018","journal-title":"Sci Transl Med"},{"key":"ref249","doi-asserted-by":"crossref","first-page":"577089","DOI":"10.1016\/j.jneuroim.2019.577089","article-title":"Inflammasome and \u03b1-synuclein in Parkinson's disease: a cross-sectional study","volume":"338","author":"K Chatterjee","year":"2020","journal-title":"J Neuroimmunol"},{"issue":"01","key":"ref250","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12974-019-1670-6","article-title":"Systemic activation of NLRP3 inflammasome and plasma \u03b1-synuclein levels are correlated with motor severity and progression in Parkinson's disease","volume":"17","author":"Z Fan","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"05","key":"ref251","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.4049\/jimmunol.1200947","article-title":"IFN-\u03b3 production by amyloid \u03b2-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease","volume":"190","author":"T C Browne","year":"2013","journal-title":"J Immunol"},{"issue":"01","key":"ref252","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neurobiolaging.2013.07.025","article-title":"Respiratory infection promotes T cell infiltration and amyloid-\u03b2 deposition in APP\/PS1 mice","volume":"35","author":"R M McManus","year":"2014","journal-title":"Neurobiol Aging"},{"issue":"10","key":"ref253","doi-asserted-by":"crossref","first-page":"e75786","DOI":"10.1371\/journal.pone.0075786","article-title":"Th17 cell-mediated neuroinflammation is involved in neurodegeneration of a\u03b21-42-induced Alzheimer's disease model rats","volume":"8","author":"J Zhang","year":"2013","journal-title":"PLoS One"},{"key":"ref254","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3389\/fimmu.2018.01213","article-title":"Imbalance of circulating Th17 and regulatory T cells in Alzheimer's disease: a case control study","volume":"9","author":"T J Oberstein","year":"2018","journal-title":"Front Immunol"},{"issue":"01","key":"ref255","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12974-018-1380-5","article-title":"Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease","volume":"16","author":"I St-Amour","year":"2019","journal-title":"J Neuroinflammation"},{"issue":"01","key":"ref256","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.stem.2018.06.015","article-title":"Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease","volume":"23","author":"A Sommer","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref257","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2017.03.045","article-title":"Increased abundance of myeloid-derived suppressor cells and Th17 cells in peripheral blood of newly-diagnosed Parkinson's disease patients","volume":"648","author":"S Chen","year":"2017","journal-title":"Neurosci Lett"},{"issue":"01","key":"ref258","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12974-018-1248-8","article-title":"Parkinson's disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1\/Th2\/T17 and Treg in drug-na\u00efve and drug-treated patients","volume":"15","author":"N Kustrimovic","year":"2018","journal-title":"J Neuroinflammation"},{"key":"ref259","doi-asserted-by":"crossref","first-page":"104575","DOI":"10.1016\/j.nbd.2019.104575","article-title":"RANTES-induced invasion of Th17 cells into substantia nigra potentiates dopaminergic cell loss in MPTP mouse model of Parkinson's disease","volume":"132","author":"D Dutta","year":"2019","journal-title":"Neurobiol Dis"},{"issue":"03","key":"ref260","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/alzrt44","article-title":"Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease","volume":"2","author":"E Stomrud","year":"2010","journal-title":"Alzheimers Res Ther"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neulet.2015.04.014","article-title":"Plasma gelsolin and matrix metalloproteinase 3 as potential biomarkers for Alzheimer disease","volume":"595","author":"M Peng","year":"2015","journal-title":"Neurosci Lett"},{"issue":"24","key":"ref262","doi-asserted-by":"crossref","first-page":"15078","DOI":"10.1074\/jbc.M114.610931","article-title":"Sequential amyloid-\u03b2 degradation by the matrix metalloproteases MMP-2 and MMP-9","volume":"290","author":"M Hernandez-Guillamon","year":"2015","journal-title":"J Biol Chem"},{"issue":"02","key":"ref263","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.expneurol.2012.07.018","article-title":"Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation","volume":"237","author":"G N\u00fcbling","year":"2012","journal-title":"Exp Neurol"},{"issue":"02","key":"ref264","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JAD-142460","article-title":"Abnormal expression and distribution of MMP2 at initial stages of Alzheimer's disease-related pathology","volume":"46","author":"B Terni","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"ref265","doi-asserted-by":"crossref","first-page":"370526","DOI":"10.1155\/2013\/370526","article-title":"MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease","volume":"2013","author":"Y C Chung","year":"2013","journal-title":"Mediators Inflamm"},{"issue":"16","key":"ref266","doi-asserted-by":"crossref","first-page":"14168","DOI":"10.1074\/jbc.M111.222430","article-title":"Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death","volume":"286","author":"D H Choi","year":"2011","journal-title":"J Biol Chem"},{"issue":"03","key":"ref267","doi-asserted-by":"crossref","first-page":"949","DOI":"10.5966\/sctm.2016-0111","article-title":"The cleavage effect of mesenchymal stem cell and its derived matrix metalloproteinase-2 on extracellular \u03b1-synuclein aggregates in Parkinsonian Models","volume":"6","author":"S H Oh","year":"2017","journal-title":"Stem Cells Transl Med"},{"issue":"01","key":"ref268","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1096\/fj.06-5865com","article-title":"A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation","volume":"21","author":"Y S Kim","year":"2007","journal-title":"FASEB J"},{"issue":"01","key":"ref269","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1471-4159.2008.05399.x","article-title":"A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells","volume":"106","author":"D H Choi","year":"2008","journal-title":"J Neurochem"},{"issue":"22","key":"ref270","doi-asserted-by":"crossref","first-page":"16444","DOI":"10.1074\/jbc.M109.093799","article-title":"Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress","volume":"285","author":"E M Kim","year":"2010","journal-title":"J Biol Chem"},{"issue":"02","key":"ref271","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.bbrc.2017.09.129","article-title":"Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide","volume":"493","author":"J Kim","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"ref272","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1172\/JCI96209","article-title":"Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology","volume":"128","author":"S B Rangasamy","year":"2018","journal-title":"J Clin Invest"},{"issue":"17","key":"ref273","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.18632\/aging.102260","article-title":"Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease","volume":"11","author":"C Zhou","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"01","key":"ref274","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12974-017-0802-0","article-title":"Aging and amyloid \u03b2 oligomers enhance TLR4 expression, LPS-induced Ca2+ responses, and neuron cell death in cultured rat hippocampal neurons","volume":"14","author":"M Calvo-Rodr\u00edguez","year":"2017","journal-title":"J Neuroinflammation"},{"key":"ref275","doi-asserted-by":"crossref","first-page":"31895","DOI":"10.1038\/srep31895","article-title":"HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease","volume":"6","author":"K Fujita","year":"2016","journal-title":"Sci Rep"},{"issue":"05","key":"ref276","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/s11064-019-02748-x","article-title":"Imbalance of microglial TLR4\/TREM2 in LPS-treated APP\/PS1 transgenic mice: a potential link between Alzheimer's disease and systemic inflammation","volume":"44","author":"J Zhou","year":"2019","journal-title":"Neurochem Res"},{"key":"ref277","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fnins.2020.00444","article-title":"Inhibition of TLR4 induces M2 microglial polarization and provides neuroprotection via the NLRP3 inflammasome in Alzheimer's disease","volume":"14","author":"W Cui","year":"2020","journal-title":"Front Neurosci"},{"issue":"01","key":"ref278","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12974-020-01738-z","article-title":"Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer's disease mice","volume":"17","author":"N Lax","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"02","key":"ref279","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00401-016-1648-8","article-title":"Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology","volume":"133","author":"N Dzamko","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"04","key":"ref280","doi-asserted-by":"crossref","first-page":"e00948","DOI":"10.1002\/brb3.948","article-title":"High expression of the HMGB1-TLR4 axis and its downstream signaling factors in patients with Parkinson's disease and the relationship of pathological staging","volume":"8","author":"Y Yang","year":"2018","journal-title":"Brain Behav"},{"issue":"01","key":"ref281","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-018-0276-2","article-title":"Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating \u03b1-synuclein transmission and neuroinflammation","volume":"13","author":"C Kim","year":"2018","journal-title":"Mol Neurodegener"},{"issue":"12","key":"ref282","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/s41401-019-0280-2","article-title":"TLR4 deficiency has a protective effect in the MPTP\/probenecid mouse model of Parkinson's disease","volume":"40","author":"Q H Shao","year":"2019","journal-title":"Acta Pharmacol Sin"},{"key":"ref283","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbi.2018.12.003","article-title":"TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model","volume":"76","author":"M Campolo","year":"2019","journal-title":"Brain Behav Immun"},{"issue":"06","key":"ref284","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1159\/000485947","article-title":"Glaucocalyxin B alleviates lipopolysaccharide-induced Parkinson's disease by inhibiting TLR\/NF-\u03baB and activating Nrf2\/HO-1 pathway","volume":"44","author":"W Xu","year":"2017","journal-title":"Cell Physiol Biochem"},{"issue":"02","key":"ref285","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ptr.6221","article-title":"Calycosin attenuates MPTP-induced Parkinson's disease by suppressing the activation of TLR\/NF-\u03baB and MAPK pathways","volume":"33","author":"J Yang","year":"2019","journal-title":"Phytother Res"},{"key":"ref286","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.lfs.2019.02.037","article-title":"Cordycepin mitigates MPTP-induced Parkinson's disease through inhibiting TLR\/NF-\u03baB signaling pathway","volume":"223","author":"C Cheng","year":"2019","journal-title":"Life Sci"},{"key":"ref287","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2017.05.016","article-title":"Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2\/MyD88\/NF-\u03baB signaling pathway","volume":"356","author":"J H Koo","year":"2017","journal-title":"Neuroscience"},{"issue":"05","key":"ref288","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/gutjnl-2018-316844","article-title":"Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice","volume":"68","author":"P Perez-Pardo","year":"2019","journal-title":"Gut"},{"key":"ref289","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbi.2018.02.005","article-title":"Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: gut microbiota, glial reaction and TLR4\/TNF-\u03b1 signaling pathway","volume":"70","author":"M F Sun","year":"2018","journal-title":"Brain Behav Immun"},{"issue":"20","key":"ref290","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1523\/JNEUROSCI.2484-16.2017","article-title":"Peripheral tumor necrosis factor-alpha (TNF-\u03b1) modulates amyloid pathology by regulating blood-derived immune cells and glial response in the brain of AD\/TNF transgenic mice","volume":"37","author":"E Paouri","year":"2017","journal-title":"J Neurosci"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neurobiolaging.2019.10.013","article-title":"Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-\u03b1 in APOE4 carriers","volume":"86","author":"J A Contreras","year":"2020","journal-title":"Neurobiol Aging"},{"issue":"05","key":"ref292","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/gps.4871","article-title":"TNF alpha inhibitors in Alzheimer's disease: a systematic 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of IL-27 in patients with Parkinson disease and their correlation with disease severity","volume":"166","author":"E Kouchaki","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"issue":"03","key":"ref296","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3233\/JPD-140410","article-title":"Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro\u00ae1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats","volume":"4","author":"C J Barnum","year":"2014","journal-title":"J Parkinsons Dis"},{"issue":"08","key":"ref297","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/jamaneurol.2018.0605","article-title":"Anti-tumor necrosis factor therapy and incidence of Parkinson disease among patients with inflammatory bowel disease","volume":"75","author":"I Peter","year":"2018","journal-title":"JAMA Neurol"},{"key":"ref298","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jneuroim.2008.09.017","article-title":"Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)","volume":"206","author":"R Zhang","year":"2009","journal-title":"J Neuroimmunol"},{"key":"ref299","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fcimb.2017.00318","article-title":"Secretory products of the human GI tract microbiome and their potential impact on Alzheimer's disease (AD): detection of lipopolysaccharide (LPS) in AD hippocampus","volume":"7","author":"Y Zhao","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"ref300","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3389\/fnagi.2017.00407","article-title":"Lipopolysaccharide (LPS) accumulates in neocortical neurons of Alzheimer's disease (AD) brain and impairs transcription in human neuronal-glial primary co-cultures","volume":"9","author":"Y Zhao","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3389\/fimmu.2017.01064","article-title":"Microbiome-derived lipopolysaccharide enriched in the perinuclear region of Alzheimer's disease brain","volume":"8","author":"Y Zhao","year":"2017","journal-title":"Front Immunol"},{"issue":"22","key":"ref302","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1212\/WNL.0000000000003391","article-title":"Gram-negative bacterial molecules associate with Alzheimer disease pathology","volume":"87","author":"X Zhan","year":"2016","journal-title":"Neurology"},{"issue":"01","key":"ref304","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1038\/s41598-019-42286-8","article-title":"Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice","volume":"9","author":"J Zhao","year":"2019","journal-title":"Sci Rep"},{"issue":"03","key":"ref305","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3233\/JAD-190295","article-title":"Lipopolysaccharide-binding protein, soluble CD14, and the long-term risk of Alzheimer's disease: a nested case-control pilot study of older community dwellers from the three-city cohort","volume":"71","author":"P Andr\u00e9","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"02","key":"ref306","first-page":"86","article-title":"Lipopolysaccharide endotoxemia induces amyloid-\u03b2 and p-tau formation in the rat brain","volume":"8","author":"L M Wang","year":"2018","journal-title":"Am J Nucl Med Mol Imaging"},{"issue":"09","key":"ref307","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1440-1827.2002.01385.x","article-title":"Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages","volume":"52","author":"K Tanji","year":"2002","journal-title":"Pathol Int"},{"issue":"08","key":"ref308","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/mds.25736","article-title":"Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease","volume":"29","author":"L P Kelly","year":"2014","journal-title":"Mov Disord"},{"issue":"06","key":"ref309","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/glia.22479","article-title":"NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration","volume":"61","author":"L Qin","year":"2013","journal-title":"Glia"},{"issue":"34","key":"ref310","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1073\/pnas.1610099113","article-title":"Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein \u03b1-synuclein","volume":"113","author":"W Wang","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"30891","DOI":"10.1038\/srep30891","article-title":"Exposure to bacterial endotoxin generates a distinct strain of \u03b1-synuclein fibril","volume":"6","author":"C Kim","year":"2016","journal-title":"Sci Rep"},{"issue":"05","key":"ref312","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1021\/acschemneuro.8b00733","article-title":"Lipopolysaccharide from gut microbiota modulates \u03b1-synuclein aggregation and alters its biological function","volume":"10","author":"D Bhattacharyya","year":"2019","journal-title":"ACS Chem Neurosci"},{"issue":"10","key":"ref313","first-page":"4942","article-title":"LPS induces dopamine depletion and iron accumulation in substantia nigra in rat models of Parkinson's disease","volume":"11","author":"J Huo","year":"2018","journal-title":"Int J Clin Exp Pathol"},{"key":"ref314","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3389\/fncel.2018.00529","article-title":"Idebenone alleviates neuroinflammation and modulates microglial polarization in LPS-stimulated BV2 cells and MPTP-induced Parkinson's disease mice","volume":"12","author":"A Yan","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"ref315","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.3389\/fimmu.2018.02527","article-title":"Polydatin prevents lipopolysaccharide (LPS)-induced Parkinson's disease via regulation of the AKT\/GSK3\u03b2-Nrf2\/NF-\u03baB signaling axis","volume":"9","author":"B Huang","year":"2018","journal-title":"Front Immunol"},{"issue":"01","key":"ref316","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12035-019-01759-7","article-title":"Gallic acid attenuated LPS-induced neuroinflammation: protein aggregation and necroptosis","volume":"57","author":"Y L Liu","year":"2020","journal-title":"Mol Neurobiol"},{"issue":"01","key":"ref317","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer's disease brains: evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"S S Dominy","year":"2019","journal-title":"Sci Adv"},{"issue":"10","key":"ref318","doi-asserted-by":"crossref","first-page":"e0204941","DOI":"10.1371\/journal.pone.0204941","article-title":"Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice","volume":"13","author":"V Ilievski","year":"2018","journal-title":"PLoS One"},{"issue":"04","key":"ref319","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3233\/JAD-200393","article-title":"Alzheimer's disease-like neurodegeneration in Porphyromonas gingivalis infected neurons with persistent expression of active gingipains","volume":"75","author":"U Haditsch","year":"2020","journal-title":"J Alzheimers Dis"},{"issue":"02","key":"ref320","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s13311-018-0611-x","article-title":"Anti-herpetic medications and reduced risk of dementia in patients with herpes simplex virus infections\u2014a Nationwide, Population-Based Cohort Study in Taiwan","volume":"15","author":"N S Tzeng","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neulet.2007.09.077","article-title":"Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation","volume":"429","author":"M A Wozniak","year":"2007","journal-title":"Neurosci Lett"},{"issue":"12","key":"ref322","doi-asserted-by":"crossref","first-page":"2323.e13","DOI":"10.1016\/j.neurobiolaging.2010.06.009","article-title":"HSV-1 promotes Ca2+ -mediated APP phosphorylation and A\u03b2 accumulation in rat cortical neurons","volume":"32","author":"R Piacentini","year":"2011","journal-title":"Neurobiol Aging"},{"issue":"02","key":"ref323","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3233\/JAD-2009-0963","article-title":"Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1","volume":"16","author":"M A Wozniak","year":"2009","journal-title":"J Alzheimers Dis"},{"issue":"05","key":"ref324","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/jnr.23003","article-title":"Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells","volume":"90","author":"G Alvarez","year":"2012","journal-title":"J Neurosci Res"},{"issue":"01","key":"ref325","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.2449","article-title":"Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques","volume":"217","author":"M A Wozniak","year":"2009","journal-title":"J Pathol"},{"issue":"04","key":"ref326","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3233\/JAD-150652","article-title":"Protective effect of amyloid-\u03b2 peptides against herpes simplex virus-1 infection in a neuronal cell culture model","volume":"50","author":"K Bourgade","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"01","key":"ref327","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuron.2018.06.030","article-title":"Alzheimer's disease-associated \u03b2-amyloid is rapidly seeded by herpesviridae to protect against brain infection","volume":"99","author":"W A Eimer","year":"2018","journal-title":"Neuron"},{"key":"ref328","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jneuroim.2016.01.007","article-title":"Humoral cross reactivity between \u03b1-synuclein and herpes simplex-1 epitope in Parkinson's disease, a triggering role in the disease?","volume":"291","author":"E Caggiu","year":"2016","journal-title":"J 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