{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:59:47Z","timestamp":1740149987229,"version":"3.37.3"},"reference-count":28,"publisher":"American Academy of Audiology","issue":"9","funder":[{"name":"Emerging Research Grant from the Hearing Health Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j am acad audiol"],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:p><jats:bold>Abstract<\/jats:bold>  <jats:bold>Background<\/jats:bold>\u2003Numerous cardiometabolic factors may underlie risk of hearing loss. Modifiable risk factors such as non-optimal blood pressure (BP) are of interest. <jats:bold>Purpose<\/jats:bold>\u2003To investigate early auditory evoked potentials (AEPs) in persons\n with nonoptimal BP. <jats:bold>Research Design<\/jats:bold>\u2003A cross-sectional nonexperimental study was performed. <jats:bold>Study Sample<\/jats:bold>\u2003Fifty-two adults (18\u201055 years) served as subjects. Individuals were classified as having optimal (systolic [S] BP\u2009&lt;\u2009120 and diastolic\n [D] BP\u2009&lt;\u200980\u2009mm Hg, <jats:italic>n<\/jats:italic>\u2009=\u200925) or non-optimal BP (SBP \u2265=120 or DBP \u2265=80\u2009mm Hg or antihypertensive use, <jats:italic>n<\/jats:italic>\u2009=\u200927). Thirteen subjects had hypertension (HTN) (SBP \u2265130 or DBP \u226580\u2009mm Hg or use of antihypertensives).\n <jats:bold>Data Collection and Analysis<\/jats:bold>\u2003Behavioral thresholds from 0.25 to 16\u2009kHz were collected. Threshold auditory brain stem responses (ABRs) were recorded using rarefaction clicks (17.7\/second) from 80\u2009dB nHL to wave V threshold. Electrocochleograms were obtained with 90\u2009dB\n nHL 7.1\/second alternating clicks and assessed for summating and compound action potentials (APs). Outcomes were compared via independent samples <jats:italic>t<\/jats:italic> tests. Linear mixed effects models for behavioral thresholds and ABR wave latencies were constructed to account for potential confounders.\n <jats:bold>Results<\/jats:bold>\u2003Wave I and III latencies were comparable between optimal and non-optimal BP groups. Wave I was prolonged in hypertensive versus optimal BP subjects at stimulus level 70\u2009dB nHL (<jats:italic>p<\/jats:italic>\u2009=\u20090.016). ABR wave V latencies were prolonged in non-optimal BP\n at stimulus level 80\u2009dB nHL (<jats:italic>p<\/jats:italic>\u2009=\u20090.048) and in HTN at levels of 80, 50, and 30\u2009dB nHL (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.050). DBP was significantly correlated with wave V latency (<jats:italic>r<\/jats:italic>\u2009=\u20090.295; <jats:italic>p<\/jats:italic>\u2009=\u20090.039). No differences\n in ABR amplitudes were observed between optimal and non-optimal BP subjects. Electrocochleographic study showed statistically comparable action and summating potential amplitudes between optimal and non-optimal BP subjects. AP latencies were also similar between the groups. Analysis using\n a set baseline amplitude of 0 \u03bcV showed that hypertensive subjects had higher summating (<jats:italic>p<\/jats:italic>\u2009=\u20090.038) and AP (<jats:italic>p<\/jats:italic>\u2009=\u20090.047) amplitudes versus optimal BP subjects; AP latencies were comparable. <jats:bold>Conclusion<\/jats:bold>\u2003Elevated BP and more specifically,\n HTN was associated with subtle AEP abnormalities. This study provides preliminary evidence that nonoptimal BP, and more specifically HTN, may be related to auditory neural dysfunction; larger confirmatory studies are warranted.<\/jats:p>","DOI":"10.1055\/s-0041-1733970","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T23:41:09Z","timestamp":1645141269000},"page":"576-587","source":"Crossref","is-referenced-by-count":0,"title":["Electrocochleography and Auditory Brainstem Responses in Persons with Non-Optimal Blood Pressure"],"prefix":"10.3766","volume":"32","author":[{"given":"Rachael R.","family":"Baiduc","sequence":"first","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, University of Colorado Boulder, Boulder, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin M.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, University of Colorado Boulder, Boulder, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Lemons","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, University of Colorado Boulder, Boulder, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Vance","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, University of Colorado Boulder, Boulder, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2087","reference":[{"issue":"19","key":"ref1","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.jacc.2017.11.005","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: Executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"P K Whelton","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"ref2","first-page":"135","article-title":"Presbycusis study of a relatively noise-free population in the Sudan","volume":"50","author":"S Rosen","year":"1962","journal-title":"Trans Am Otol Soc"},{"issue":"03","key":"ref3","first-page":"152","article-title":"Risk factors related to age-associated hearing loss in the speech frequencies","volume":"7","author":"L J Brant","year":"1996","journal-title":"J Am Acad Audiol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"e028392","DOI":"10.1136\/bmjopen-2018-028392","article-title":"Association between hypertension and hearing impairment in health check-ups among Japanese workers: a cross-sectional study","volume":"9","author":"M Umesawa","year":"2019","journal-title":"BMJ Open"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/jamaoto.2015.0889","article-title":"Hearing impairment prevalence and associated risk factors in the Hispanic Community Health Study\/Study of Latinos","volume":"141","author":"K J Cruickshanks","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ypmed.2011.08.012","article-title":"Modifiable determinants of hearing impairment in adults","volume":"53","author":"W Zhan","year":"2011","journal-title":"Prev Med"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/MAO.0b013e318192483c","article-title":"Risk factors for hearing loss in US adults: data from the National Health and Nutrition Examination Survey, 1999 to 2002","volume":"30","author":"Y Agrawal","year":"2009","journal-title":"Otol Neurotol"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/01050399309046025","article-title":"Epidemiology of hearing disorders. 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