{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:55:27Z","timestamp":1777953327033,"version":"3.51.4"},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dengue, with four viral serotypes, causes epidemics in tropical and sub-tropical regions. Allopathic antiviral therapies and a vaccine of general use are lacking. The homeopathic medicine Apis mellifica, advised in anaphylaxis from honeybee sting, is proposed to address the life-threatening dengue shock syndrome, which develops from dengue hemorrhagic fever and has features of anaphylaxis. In both dengue and anaphylaxis, immunoglobulin E activates, and released vasoactive mediators (importantly histamine, tryptase and platelet-activating factor) cause, a vascular permeability enabling shock. In dengue, another mechanism, namely antibody-dependent enhancement, due to secondary infection with a heterologous dengue serotype, is associated with release of vasoactive mediators. The homeopathic medicine Apis mellifica indicates plasma leak, shock, and the serous effusion that is noted in dengue patients, and is a suggested prophylactic and therapeutic medicine for dengue shock syndrome.<\/jats:p>","DOI":"10.1055\/s-0041-1734027","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T23:55:20Z","timestamp":1636415720000},"page":"226-231","source":"Crossref","is-referenced-by-count":3,"title":["Dengue Shock Syndrome: Its Similarity with Anaphylaxis and with the Homeopathic Medicine Apis mellifica (European Honeybee)"],"prefix":"10.1055","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-6878","authenticated-orcid":false,"given":"Cornelia","family":"Richardson-Boedler","sequence":"additional","affiliation":[{"name":"Berkeley, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/CMR.11.3.480","article-title":"Dengue and dengue hemorrhagic fever","volume":"11","author":"D J Gubler","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.51910\/ijhdr.v7i25.312","article-title":"Homeopathy and collective health: the case of dengue epidemics","volume":"7","author":"R Marino","year":"2008","journal-title":"Int J High Dilution Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-med-050715-105122","article-title":"Zika, chikungunya, and other emerging vector-borne viral diseases","volume":"69","author":"S C Weaver","year":"2018","journal-title":"Annu Rev Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e0200698","DOI":"10.1371\/journal.pone.0200698","article-title":"The association between obesity and dengue virus (DENV) infection in hospitalised patients","volume":"13","author":"V PK Tan","year":"2018","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/tropicalmed5040170","article-title":"Risk factors for elevated serum lipopolysaccharide in acute dengue and association with clinical disease severity","volume":"5","author":"N LA Shyamali","year":"2020","journal-title":"Trop Med Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00103-019-03060-3","article-title":"Dengue vaccine development: status and future","volume":"63","author":"A Wilder-Smith","year":"2020","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"ref8","first-page":"75","article-title":"Could homeopathy become an alternative therapy in dengue fever? 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