{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:08:48Z","timestamp":1791216528341,"version":"4.1.0"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":155,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Radiol Imaging"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Purpose Our case report presents the first case of suprasellar hemangioblastoma diagnosed preoperatively with dynamic computed tomography angiography (four-dimensional [4D] CTA) in a patient without Von Hippel-Lindau (VHL) disease. We illustrate the imaging characteristics of these exceedingly rare tumors and discuss the role of 4D CTA in confirming this diagnosis and guiding surgical management. Finally, we present a literature review of imaging findings, differential diagnosis, management, and prognosis.<\/jats:p><jats:p>Case A 39-year-old woman known for diabetes mellitus type II and dyslipidemia presented with headache, bitemporal hemianopsia, and mild hyperprolactinemia. Initial diagnosis of suprasellar meningioma separate from pituitary gland was revised to definitive diagnosis of suprasellar hemangioblastoma after 4D CTA.<\/jats:p><jats:p>Conclusion Suprasellar hemangioblastomas are extremely rare, often associated to VHL disease. They present as enhancing as suprasellar mass with prominent intra- and peritumoral vascular flow-voids on magnetic resonance imaging. 4D CTA confirms their vascular nature, demonstrates characteristic rapid shunting with feeding arteries, and enlarged draining veins, and is important in guiding surgical management.<\/jats:p>","DOI":"10.1055\/s-0041-1734335","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T23:01:42Z","timestamp":1630710102000},"page":"499-509","source":"Crossref","is-referenced-by-count":4,"title":["Preoperative Diagnosis of Suprasellar Hemangioblastoma with Four-Dimensional Computed Tomography Angiography: Case Report and Literature Review"],"prefix":"10.1055","volume":"31","author":[{"given":"Yi","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Radiology, McGill University Health Center, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Sirhan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Montreal Neurological Hospital and Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cortes","sequence":"additional","affiliation":[{"name":"Department of Radiology, McGill University Health Center, Montreal, Quebec, Canada"},{"name":"Department of Radiology, Montreal Neurological Hospital and Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"ref1","first-page":"955","volume-title":"Hemangioblastomas of the Central Nervous System","author":"A Metelo","year":"2015"},{"issue":"06","key":"ref2","first-page":"7553","article-title":"Suprasellar hemangioblastoma without von Hippel-Lindau disease: a case report and literature review","volume":"8","author":"Z Li","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/neuonc\/nos133","article-title":"Supratentorial hemangioblastoma: clinical features, prognosis, and predictive value of location for von Hippel-Lindau disease","volume":"14","author":"S A Mills","year":"2012","journal-title":"Neuro-oncol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0009-9260(81)80276-0","article-title":"Supratentorial haemangioblastoma: the diagnostic roles of computed tomography and angiography","volume":"32","author":"G V O'Reilly","year":"1981","journal-title":"Clin Radiol"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0090-3019(84)90010-7","article-title":"Suprasellar hemangioblastoma","volume":"22","author":"F Grisoli","year":"1984","journal-title":"Surg Neurol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3171\/jns.1996.85.4.0591","article-title":"Gamma knife radiosurgery in 11 hemangioblastomas","volume":"85","author":"M Niemel\u00f6","year":"1996","journal-title":"J Neurosurg"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.3171\/jns.2000.92.6.1028","article-title":"Resection of suprasellar tumors by using a modified transsphenoidal approach. Report of four cases","volume":"92","author":"J Kouri","year":"2000","journal-title":"J Neurosurg"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0090-3019(01)00482-7","article-title":"Suprasellar hemangioblastoma in a patient with von Hippel-Lindau disease confirmed by germline mutation study: case report and review of the literature","volume":"56","author":"T Goto","year":"2001","journal-title":"Surg Neurol"},{"issue":"07","key":"ref9","first-page":"679","article-title":"A case of suprasellar hemangioblastoma with thoracic meningioma [in Japanese]","volume":"29","author":"M Ikeda","year":"2001","journal-title":"No Shinkei Geka"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0899-7071(02)00537-5","article-title":"Suprasellar hemangioblastoma in Von Hippel-Lindau disease: a case report","volume":"27","author":"J J Wasenko","year":"2003","journal-title":"Clin Imaging"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jocn.2004.02.025","article-title":"Sav A, Pamir MN. Suprasellar haemangioblastoma. Report of two cases and review of the literature","volume":"12","author":"S Peker","year":"2005","journal-title":"J Clin Neurosci"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.clineuro.2006.11.007","article-title":"Pituitary stalk hemangioblastoma: the fourth case report and review of the literature","volume":"109","author":"E Fomekong","year":"2007","journal-title":"Clin Neurol Neurosurg"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/WNO.0b013e318183c633","article-title":"Suprasellar hemangioblastoma","volume":"28","author":"S Miyata","year":"2008","journal-title":"J Neuroophthalmol"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3171\/2008.4.17532","article-title":"Pituitary stalk hemangioblastomas in von Hippel-Lindau disease","volume":"110","author":"R R Lonser","year":"2009","journal-title":"J Neurosurg"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1227\/01.NEU.0000374846.86409.A7","article-title":"Natural history of supratentorial hemangioblastomas in von Hippel-Lindau disease","volume":"67","author":"M Peyre","year":"2010","journal-title":"Neurosurgery"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1017\/S0317167100010945","article-title":"Pituitary infundibulum hemangioblastoma detected by dynamic enhancement MRI","volume":"37","author":"Y Cao","year":"2010","journal-title":"Can J Neurol Sci"},{"issue":"496","key":"ref17","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1186\/1752-1947-5-496","article-title":"Manifestation of a sellar hemangioblastoma due to pituitary apoplexy: a case report","volume":"5","author":"R T Sch\u00f6r","year":"2011","journal-title":"J Med Case Reports"},{"issue":"04","key":"ref18","first-page":"176","article-title":"Sellar hemangioblastoma mimicking a macroadenoma","volume":"21","author":"P Ajler","year":"2012","journal-title":"Acta Neurol Taiwan"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2176\/nmc.cr2011-0016","article-title":"Suprasellar hemangioblastoma mimicking a craniopharyngioma: result of extended endoscopic transsphenoidal approach-case report","volume":"53","author":"T Xie","year":"2013","journal-title":"Neurol Med Chir (Tokyo"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3340\/jkns.2015.57.6.465","article-title":"Sporadic hemangioblastoma in the pituitary stalk: a case report and review of the literature","volume":"57","author":"G I Lee","year":"2015","journal-title":"J Korean Neurosurg Soc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"693.e7","DOI":"10.1016\/j.wneu.2015.12.030","article-title":"Infundibular hemangioblastoma in a patient with neurofibromatosis type 1: case report and review of the literature","volume":"88","author":"J Kosty","year":"2016","journal-title":"World Neurosurg"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/s-0036-1582016","article-title":"Suprasellar hemangioblastoma unrelated to von Hippel-Lindau disease successfully treated through extended transsphenoidal approach: diagnostic value of Von Hippel-Lindau disease gene-derived protein","volume":"78","author":"J Wenting","year":"2017","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"40822","DOI":"10.1038\/srep40822","article-title":"Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target","volume":"7","author":"S Sizdahkhani","year":"2017","journal-title":"Sci Rep"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3941\/jrcr.v11i5.2981","article-title":"Sporadic hemangioblastoma arising from the infundibulum","volume":"11","author":"M N Pakdaman","year":"2017","journal-title":"J Radiol Case Rep"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.clineuro.2018.03.010","article-title":"Surgical approach for suprasellar hemangioblastomas preserving the pituitary stalk: review of the literature and report of a further case","volume":"168","author":"N Alshafai","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.wneu.2018.03.114","article-title":"Suprasellar hemangioblastoma with reversible edema-like change along the optic tract: a case report and literature review","volume":"114","author":"Y Hattori","year":"2018","journal-title":"World Neurosurg"},{"key":"ref27","first-page":"197","volume-title":"Craniopharyngiomas","author":"G Zada","year":"2016"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3171\/jns.1995.83.2.0206","article-title":"Papillary craniopharyngioma: a clinicopathological study of 48 cases","volume":"83","author":"T B Crotty","year":"1995","journal-title":"J Neurosurg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-3-319-22855-6_28","volume-title":"Meningioma of the sellar and parasellar region","author":"G Zada","year":"2016"},{"issue":"07","key":"ref30","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11604-016-0550-6","article-title":"Variants of meningiomas: a review of imaging findings and clinical features","volume":"34","author":"A Kunimatsu","year":"2016","journal-title":"Jpn J Radiol"},{"key":"ref31","first-page":"271","volume-title":"Hemangiopericytoma","author":"G Zada","year":"2016"},{"key":"ref32","first-page":"425","article-title":"Recurrent sellar and suprasellar hemangiopericytoma","volume":"41","author":"M H Han","year":"2007","journal-title":"J Korean Neurosurg Soc"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00701-007-1474-9","article-title":"Suprasellar haemangiopericytoma-challenges in diagnosis and treatment","volume":"150","author":"R Jalali","year":"2008","journal-title":"Acta Neurochir (Wien"},{"issue":"03","key":"ref34","first-page":"464","article-title":"Chordoid glioma: a neoplasm unique to the hypothalamus and anterior third ventricle","volume":"22","author":"M G Pomper","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00701-018-3465-4","article-title":"Clinical applications of dynamic CT angiography for intracranial lesions","volume":"160","author":"S Gupta","year":"2018","journal-title":"Acta Neurochir (Wien"},{"issue":"01","key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2014.10.JNS141055","article-title":"Al-Mefty O, Mukundan S Jr, Dunn IF. Utility of dynamic computed tomography angiography in the preoperative evaluation of skull base tumors","volume":"123","author":"W L Bi","year":"2015","journal-title":"J Neurosurg"},{"issue":"07","key":"ref37","first-page":"1187","article-title":"Detection and characterization of very small cerebral aneurysms by using 2D and 3D helical CT angiography","volume":"23","author":"J P Villablanca","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1177\/0284185113520153","article-title":"Flow artifact in the anterior communicating artery resembling aneurysm on the time of flight MR angiogram","volume":"55","author":"D Takhtani","year":"2014","journal-title":"Acta Radiol"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"i44","DOI":"10.1093\/neuonc\/noy143","article-title":"International Consortium on Meningiomas. 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