{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:17:44Z","timestamp":1740154664457,"version":"3.37.3"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":118,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Radiol Imaging"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Motor neuron diseases cause progressive degeneration of upper and lower motor neurons. No Indian studies are available on diffusion tensor imaging (DTI) findings in these patients.<\/jats:p><jats:p>\n          Aims This study was done to identify white matter tracts that have reduced fractional anisotropy (FA) in motor neuron disease (MND) patients using tract-based spatial statistics and to correlate FA values with Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) score.<\/jats:p><jats:p>\n          Settings and Design A case\u2013control study in a tertiary care hospital.<\/jats:p><jats:p>\n          Materials and Methods We did DTI sequence (20 gradient directions, b-value 1,000) in 15 MND patients (10 men and 5 women; mean age: 46.5 \u00b1 16.5 years; 11 amyotrophic lateral sclerosis [ALS], 2 monomelic amyotrophy, 1 progressive muscular atrophy, and 1 bulbar ALS) and 15 age- and sex-matched controls. The data set from each subject was postprocessed using FSL downloaded from the FMRIB Software Library, Oxford, United Kingdom (http:\/\/www.fmrib.ox.ac.uk\/fsl).<\/jats:p><jats:p>\n          Statistical Analysis The statistical permutation tool \u201crandomize\u201d with 5,000 permutations was used to identify voxels that were different between the patient data set and the control data set. Mean FA values of these voxels were obtained separately for each tract as per \u201cJHU white-matter tractography atlas.\u201d SPSS was used to look to correlate tract-wise mean FA value with ALSFRS-R score.<\/jats:p><jats:p>\n          Results We found clusters of reduced FA values in multiple tracts in the brain of patients with MND. Receiver operating characteristic curves plotted for individual tracts, showed that bilateral corticospinal tract, bilateral anterior thalamic radiation, bilateral uncinate fasciculus, and right superior longitudinal fasciculus were the best discriminators (area under the curve &gt; 0.8, p &lt; 0.01). FA values did not correlate with ALFRS-R severity score.<\/jats:p><jats:p>\n          Conclusion In MND patients, not only the motor tracts, but several nonmotor association tracts are additionally affected, reflecting nonmotor pathological processes in ALS.<\/jats:p>","DOI":"10.1055\/s-0041-1734337","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T23:13:45Z","timestamp":1627514025000},"page":"297-303","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of White Matter Tracts Fractional Anisotropy Using Tract-Based Spatial Statistics and Its correlation with Amyotrophic Lateral Sclerosis Functional Rating Scale Score in Patients with Motor Neuron Disease"],"prefix":"10.1055","volume":"31","author":[{"given":"Amutha Bharathi","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1464-9911","authenticated-orcid":false,"given":"Subathra","family":"Adithan","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagarajan","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India"},{"name":"Department of Neurology, Christian Medical College (CMC), Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/B978-0-12-802973-2.00013-6","article-title":"The epidemiology of amyotrophic lateral sclerosis","volume":"138","author":"E O Talbott","year":"2016","journal-title":"Handb Clin Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"12408","DOI":"10.1038\/ncomms12408","article-title":"Projected increase in amyotrophic lateral sclerosis from 2015 to 2040","volume":"7","author":"K C Arthur","year":"2016","journal-title":"Nat Commun"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jns.2004.08.014","article-title":"Diffusion tensor MRI as a diagnostic tool of upper motor neuron involvement in amyotrophic lateral sclerosis","volume":"227","author":"Y-H Hong","year":"2004","journal-title":"J Neurol Sci"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"e105753","DOI":"10.1371\/journal.pone.0105753","article-title":"Linear associations between clinically assessed upper motor neuron disease and diffusion tensor imaging metrics in amyotrophic lateral sclerosis","volume":"9","author":"J H Woo","year":"2014","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.nicl.2017.02.017","article-title":"Differential involvement of corticospinal tract (CST) fibers in UMN-predominant ALS patients with or without CST hyperintensity: a diffusion tensor tractography study","volume":"14","author":"V Rajagopalan","year":"2017","journal-title":"Neuroimage Clin"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fneur.2019.00193","article-title":"White matter microstructure breakdown in the motor neuron disease spectrum: recent advances using diffusion magnetic resonance imaging","volume":"10","author":"S Basaia","year":"2019","journal-title":"Front Neurol"},{"issue":"01\/02","key":"ref7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"BDNF ALS Study Group (Phase III). The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function","volume":"169","author":"J M Cedarbaum","year":"1999","journal-title":"J Neurol Sci"},{"issue":"09","key":"ref8","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1007\/s00415-012-6420-y","article-title":"White matter pathology in ALS and lower motor neuron ALS variants: a diffusion tensor imaging study using tract-based spatial statistics","volume":"259","author":"J Prudlo","year":"2012","journal-title":"J Neurol"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s13311-010-0011-3","article-title":"Neuroimaging in amyotrophic lateral sclerosis","volume":"8","author":"S Wang","year":"2011","journal-title":"Neurotherapeutics"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3348\/kjr.2011.12.6.651","article-title":"Diffusion tensor imaging: exploring the motor networks and clinical applications","volume":"12","author":"S Ahn","year":"2011","journal-title":"Korean J Radiol"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00062-013-0221-2","article-title":"Diffusion tensor imaging in amyotrophic lateral sclerosis\u2013increased sensitivity with optimized region-of-interest delineation","volume":"24","author":"T Prokscha","year":"2014","journal-title":"Clin Neuroradiol"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1002\/hbm.20794","article-title":"Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis: revisited","volume":"30","author":"C A Sage","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2010.05.067","article-title":"Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in amyotrophic lateral 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Keil","year":"2012","journal-title":"BMC Neurosci"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"0137905","DOI":"10.1371\/journal.pone.0137905","article-title":"Impact of MR acquisition parameters on DTI scalar indexes: a tractography based approach","volume":"10","author":"G Barrio-Arranz","year":"2015","journal-title":"PLoS One"},{"issue":"08","key":"ref24","doi-asserted-by":"crossref","first-page":"e943","DOI":"10.1212\/WNL.0000000000010235","article-title":"A prospective harmonized multicenter DTI study of cerebral white matter degeneration in ALS","volume":"95","author":"S Kalra","year":"2020","journal-title":"Neurology"},{"issue":"06","key":"ref25","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3174\/ajnr.A0488","article-title":"Diffusion anisotropy measurement of brain white matter is affected by voxel size: underestimation occurs in areas with crossing fibers","volume":"28","author":"H Oouchi","year":"2007","journal-title":"AJNR Am J 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