{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:39:59Z","timestamp":1777610399867,"version":"3.51.4"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":117,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Radiol Imaging"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Differentiating Graves\u2019 disease from thyroiditis can be at times clinically challenging. The gold standard test (thyroid nuclear imaging scan) is expensive, not routinely available, and has radiation exposure. Color Doppler ultrasonography of thyroid represents a suitable alternate which can be used for differentiating these conditions by studying thyroid blood flow parameters.<\/jats:p><jats:p>\n          Aim We aimed to investigate the use of thyroid blood flow parameters\u2019 assessment of the superior thyroid artery (STA) and common carotid artery (CCA) with color Doppler ultrasonography for differentiating Graves\u2019 disease from thyroiditis.<\/jats:p><jats:p>\n          Materials and Methods This is a cross-sectional study on 111 patients with newly diagnosed thyrotoxicosis (82 with Graves\u2019 disease and 29 with thyroiditis) and 45 years of age and sex-matched healthy controls. All patients underwent detailed clinical and necessary investigations. Color Doppler ultrasonography of the thyroid gland and spectral flow analysis of both superior thyroid arteries was done using standard protocol. Sensitivity and specificity for mean peak systolic velocity of STA (STA-PSV) cut-offs were calculated using receiver operating characteristic curves.<\/jats:p><jats:p>\n          Results Patients with Graves\u2019 disease have significantly higher free tri-iodothyronine (FT3) levels, free thyroxine (FT4) levels, antithyroid stimulating hormone receptor antibody (TRAb) levels, and thyroid volume as compared with those with thyroiditis. The mean STA-PSV of patients with Graves\u2019 disease was significantly higher than thyroiditis and control group. Mean STA-PSV greater than 54.3 cm\/s had 82.9% sensitivity and 86.2% specificity in diagnosing Graves\u2019 disease. Mean PSV-STA\/PSV-CCA ratio of 0.40 was 80.5% sensitive and 86.2% specific for Graves\u2019 disease.<\/jats:p><jats:p>\n          Conclusion Mean STA-PSV has high sensitivity and specificity in differentiating Graves\u2019 disease from thyroiditis and can be used routinely in clinical practice as a cheap and invaluable diagnostic tool.<\/jats:p>","DOI":"10.1055\/s-0041-1734360","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T01:17:53Z","timestamp":1627435073000},"page":"311-317","source":"Crossref","is-referenced-by-count":13,"title":["Diagnostic Utility of Mean Peak Systolic Velocity of Superior Thyroid Artery in Differentiating Graves\u2019 Disease from Thyroiditis"],"prefix":"10.1055","volume":"31","author":[{"given":"Pradosh K.","family":"Sarangi","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasmita","family":"Parida","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Pandit Raghunath Murmu Medical College and Hospital, Baripada, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swayamsidha","family":"Mangaraj","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binoy K.","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Maharaja Krishna Chandra Gajapati Medical College and Hospital, Berhampur, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayashree","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basanta M.","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.4158\/EP11170.RA","article-title":"Role of ultrasonography in the differential diagnosis of thyrotoxicosis: a noninvasive, cost-effective, and widely available but underutilized diagnostic tool","volume":"18","author":"A S Alzahrani","year":"2012","journal-title":"Endocr Pract"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12902-019-0388-x","article-title":"Mean peak systolic velocity of superior thyroid artery for the differential diagnosis of thyrotoxicosis: a diagnostic meta-analysis","volume":"19","author":"X Peng","year":"2019","journal-title":"BMC Endocr Disord"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1089\/thy.2005.15.1249","article-title":"Measurement of thyroid blood flow area is useful for diagnosing the cause of thyrotoxicosis","volume":"15","author":"S Kurita","year":"2005","journal-title":"Thyroid"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4158\/EP13300.OR","article-title":"The diagnostic utility of color doppler ultrasonography, Tc-99m pertechnetate uptake, and tsh-receptor antibody for differential diagnosis of Graves\u2019 disease and silent thyroiditis: A comparative study","volume":"20","author":"S S Zuhur","year":"2014","journal-title":"Endocr Pract"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/BF03349833","article-title":"Thyroid blood flow evaluation by color-flow Doppler sonography distinguishes Graves\u2019 disease from Hashimoto\u2019s thyroiditis","volume":"18","author":"P Vitti","year":"1995","journal-title":"J Endocrinol Invest"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/thy.2010.0417","article-title":"American Thyroid Association; American Association of Clinical Endocrinologists. 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Systematic review and meta-analysis","volume":"12","author":"R Tozzoli","year":"2012","journal-title":"Autoimmun Rev"}],"container-title":["Indian Journal of Radiology and Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1734360.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T23:13:30Z","timestamp":1631747610000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1734360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":19,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2021,9,15]]},"published-print":{"date-parts":[[2021,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1734360","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0971-3026","1998-3808"],"issn-type":[{"value":"0971-3026","type":"print"},{"value":"1998-3808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}