{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:36:28Z","timestamp":1790721388736,"version":"4.1.0"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"05\/06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Unexplained infertility (UI) and recurrent implantation failure (RIF) are diagnoses based on failed pregnancy attempts within current infertility treatment models. Both diagnoses are made when fertility is unexplained based on current diagnostic methods and has no clear cause; UI is diagnosed when testing is inconclusive, and RIF is diagnosed after three failed in vitro fertilization cycles. In both cases, interventions are often introduced without an understanding of the cause of the infertility, frequently leading to frustration for patients and caregivers. Here, we review evidence to support an influence of endometrial factor in patients given these poorly defined diagnoses and possible treatments targeting the endometrium to improve outcomes in these patients.<\/jats:p>","DOI":"10.1055\/s-0041-1735199","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T23:00:03Z","timestamp":1629759603000},"page":"227-232","source":"Crossref","is-referenced-by-count":13,"title":["Endometrial Factor in Unexplained Infertility and Recurrent Implantation Failure"],"prefix":"10.1055","volume":"39","author":[{"given":"Xavier","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Igenomix Foundation, INCLIVA Health Research Institute, Valencia, Spain"},{"name":"Vall Hebron Institut de Recerca (VHIR), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Igenomix Foundation, INCLIVA Health Research Institute, Valencia, Spain"},{"name":"Department of Obstetrics and Gynecology, University of Valencia, Valencia, Spain"},{"name":"Department of Obstetrics and Gynecology, BIDMC, Harvard University, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.fertnstert.2016.02.001","article-title":"Evidence-based approach to unexplained infertility: a systematic review","volume":"105","author":"D D Gunn","year":"2016","journal-title":"Fertil Steril"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/GCO.0000000000000468","article-title":"Implantation failure of endometrial origin: what is new?","volume":"30","author":"J Bellver","year":"2018","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.fertnstert.2003.06.029","article-title":"Why do couples discontinue in vitro fertilization treatment? 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