{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:51:55Z","timestamp":1761709915388,"version":"3.37.3"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Angiol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elastic compressions are standard treatment for leg ulcers of venous etiology. The effect of compressions on ulcers of mixed (arterial or venous) etiology, however, has rarely been studied. The objective of this study was to evaluate the variation in transcutaneous oxygen pressure (TcPO2) in patients with ulcers of mixed arterial or venous etiology treated with 1 month of compression. This prospective cohort study was conducted at a university hospital in France. Patient eligibility was for those attending a consultation of a work-up of a leg ulcer of mixed arterial-venous etiology lasting at least 4 to 6 weeks. Compressions were prescribed according to the hemodynamic status and were evaluated by the ankle-brachial index and toe-brachial index using a decision-making algorithm based on French national guidelines. Quality of life was assessed using the Short-Form 36-Item (SF-36) questionnaire. In total, 32 patients were included between September 30, 2018 and May 31, 2019. A difference was observed between TcPO2 before compression (49.3\u2009\u00b1\u200913.01\u2009mm Hg) and after 1 month (51.2\u2009\u00b1\u200915.05\u2009mm Hg), average change 1.9\u2009\u00b1\u20092.04\u2009mm Hg (p\u2009=\u20090.025). The average ulcer size prior to compression was 49\u2009\u00b1\u2009102\u2009cm2 versus 37\u2009\u00b1\u200994\u2009cm2 after 1 month of effective compression, corresponding to a reduction of 12\u2009\u00b1\u20098\u2009cm2 (p\u2009&lt;\u20090.001). There was a reduction in the bodily pain dimension of the SF-36. Compressions adapted to the hemodynamic status led to an increase in TcPO2, a reduction in wound size, and an improvement to bodily pain in patients with leg ulcers of mixed arterial-venous etiology.<\/jats:p>","DOI":"10.1055\/s-0041-1735204","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T22:35:56Z","timestamp":1630449356000},"page":"034-039","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Efficacy and Safety of Long-Term Compression in Patients with Mixed Arterial and Venous Etiology Ulcers in the Leg"],"prefix":"10.1055","volume":"31","author":[{"given":"Sophie","family":"Elhomsy","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Centre Hospitalier de Troyes, Troyes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Chrusciel","sequence":"additional","affiliation":[{"name":"Department of Public Health, Centre Hospitalier de Troyes, Troyes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0925-6948","authenticated-orcid":false,"given":"St\u00e9phane","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Public Health, Centre Hospitalier de Troyes, Troyes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Elhomsy","sequence":"additional","affiliation":[{"name":"Palliative Care Unit, Dijon Teaching Hospital, Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Guillaumat","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Caen Teaching Hospital, Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jaad.2014.10.048","article-title":"What's new: management of venous leg ulcers: approach to venous leg ulcers","volume":"74","author":"A Alavi","year":"2016","journal-title":"J Am Acad Dermatol"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1365-2133.2003.05222.x","article-title":"Causes, investigation and treatment of leg ulceration","volume":"148","author":"J R Mekkes","year":"2003","journal-title":"Br J Dermatol"},{"issue":"04","key":"ref3","first-page":"60","article-title":"A predictive model for venous ulceration in older adults: results of a retrospective cohort study","volume":"56","author":"P Y Takahashi","year":"2010","journal-title":"Ostomy Wound Manage"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/bjs.5757","article-title":"Management of mixed arterial and venous leg ulcers","volume":"94","author":"M L Humphreys","year":"2007","journal-title":"Br J Surg"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1610-0387.2010.07535.x","article-title":"Etiology of chronic leg ulcers in 31,619 patients in Germany analyzed by an expert survey","volume":"9","author":"A K\u00f6rber","year":"2011","journal-title":"J Dtsch Dermatol Ges"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.7326\/0003-4819-138-4-200302180-00012","article-title":"Managing the patient with venous ulcers","volume":"138","author":"T de Araujo","year":"2003","journal-title":"Ann Intern Med"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1742-481X.2012.01089.x","article-title":"Cost-of-illness of leg ulcers in the community","volume":"11","author":"M Augustin","year":"2014","journal-title":"Int Wound J"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1024\/0301-1526\/a000083","article-title":"Quality of life and satisfaction of patients with leg ulcers\u2013results of a community-based study","volume":"40","author":"K Herberger","year":"2011","journal-title":"Vasa"},{"key":"ref9","first-page":"CD000265","article-title":"Compression for venous leg ulcers","volume":"11","author":"S O'Meara","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"57","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta18570","article-title":"VenUS IV (Venous leg Ulcer Study IV) - compression hosiery compared with compression bandaging in the treatment of venous leg ulcers: a randomised controlled trial, mixed-treatment comparison and decision-analytic model","volume":"18","author":"R L Ashby","year":"2014","journal-title":"Health Technol Assess"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jvs.2011.07.071","article-title":"Compression therapy in mixed ulcers increases venous output and arterial perfusion","volume":"55","author":"G Mosti","year":"2012","journal-title":"J Vasc Surg"},{"issue":"09","key":"ref12","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1111\/jdv.14390","article-title":"Compression therapy for venous leg ulcers: risk factors for adverse events and complications, contraindications - a review of present guidelines","volume":"31","author":"A Andriessen","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"24","key":"ref13","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1161\/CIR.0b013e318276fbcb","article-title":"Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association","volume":"126","author":"V Aboyans","year":"2012","journal-title":"Circulation"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jvs.2013.03.044","article-title":"The toe-brachial index in the diagnosis of peripheral arterial disease","volume":"58","author":"C H\u00f8yer","year":"2013","journal-title":"J Vasc Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/153857440003400307","article-title":"Transcutaneous oximetry, laser Doppler fluxmetry, and capillary microscopy: variability in patients with advanced atherosclerotic disease of the lower extremity","volume":"34","author":"H M Klomp","year":"2000","journal-title":"Vasc Surg"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/014107688607901111","article-title":"Transcutaneous measurements of oxygen tension at edges of leg ulcers: preliminary communication","volume":"79","author":"R Mani","year":"1986","journal-title":"J R Soc Med"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7150\/ijms.7548","article-title":"A comparative clinical study on five types of compression therapy in patients with venous leg ulcers","volume":"11","author":"P Dolibog","year":"2013","journal-title":"Int J Med Sci"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jmv.2013.05.006","article-title":"Compression therapy in 100 consecutive patients with venous leg ulcers","volume":"38","author":"A Stansal","year":"2013","journal-title":"J Mal Vasc"}],"container-title":["International Journal of Angiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1735204.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T10:48:15Z","timestamp":1673174895000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1735204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":18,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,2,25]]},"published-print":{"date-parts":[[2022,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1735204","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1061-1711","1615-5939"],"issn-type":[{"type":"print","value":"1061-1711"},{"type":"electronic","value":"1615-5939"}],"subject":[],"published":{"date-parts":[[2021,8,31]]}}}