{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:41Z","timestamp":1740126821420,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"14","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD34208"],"award-info":[{"award-number":["HD34208"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD53097"],"award-info":[{"award-number":["HD53097"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40545"],"award-info":[{"award-number":["HD40545"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40560"],"award-info":[{"award-number":["HD40560"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD27869"],"award-info":[{"award-number":["HD27869"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40485"],"award-info":[{"award-number":["HD40485"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40512"],"award-info":[{"award-number":["HD40512"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD27915"],"award-info":[{"award-number":["HD27915"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40544"],"award-info":[{"award-number":["HD40544"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40500"],"award-info":[{"award-number":["HD40500"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD68282"],"award-info":[{"award-number":["HD68282"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD68268"],"award-info":[{"award-number":["HD68268"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD27917"],"award-info":[{"award-number":["HD27917"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD21410"],"award-info":[{"award-number":["HD21410"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD36801"],"award-info":[{"award-number":["U10 HD36801"]}]},{"name":"Neoventa Medical"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to evaluate whether intrapartum fetal electrocardiogram (ECG) tracings with ST-elevation or depression occur more frequently in each stage of labor in small-for-gestational age (SGA) or large-for-gestational age (LGA), as compared with appropriate-for-gestational age (AGA) fetuses.<\/jats:p><jats:p>\n            Study Design\u2003We conducted a secondary analysis of a large, multicenter trial in which laboring patients underwent fetal ECG waveform-analysis. We excluded participants with diabetes mellitus and major fetal anomalies. Birth weight was categorized as SGA (&lt;10th percentile), LGA (&gt;90th percentile), or AGA (10\u201390th percentile) by using a gender and race\/ethnicity specific nomogram. In adjusted analyses, the frequency of ECG tracings with ST-depression or ST-elevation without depression was compared according to birthweight categories and labor stage.<\/jats:p><jats:p>\n            Results\u2003Our study included 4,971 laboring patients in the first stage and 4,074 in the second stage. During the first stage of labor, there were no differences in the frequency of ST-depression in SGA fetuses compared with AGA fetuses (6.7 vs. 5.5%; adjusted odds ratio [aOR]: 1.41, 95% confidence interval [CI]: 0.93\u20132.13), or in ST-elevation without depression (35.8 vs. 34.1%; aOR: 1.17, 95% CI: 0.94\u20131.46). During the second stage, there were no differences in the frequency of ST-depression in SGA fetuses compared with AGA fetuses (1.6 vs. 2.0%; aOR: 0.69, 95% CI: 0.27\u20131.73), or in ST-elevation without depression (16.2 vs. 18.1%; aOR: 0.90, 95% CI: 0.67\u20131.22). During the first stage of labor, there were no differences in the frequency of ST-depression in LGA fetuses compared with AGA fetuses (6.3 vs. 5.5%; aOR: 0.97, 95% CI: 0.60\u20131.57), or in ST-elevation without depression (33.1 vs. 34.1%; aOR: 0.80, 95% CI: 0.62\u20131.03); during the second stage of labor, the frequency of ST-depression in LGA compared with AGA fetuses (2.5 vs. 2.0%, aOR: 1.36, 95% CI: 0.61\u20133.03), and in ST-elevation without depression (15.5 vs. 18.1%; aOR: 0.83, 95% CI: 0.58\u20131.18) were similar as well.<\/jats:p><jats:p>\n            Conclusion\u2003The frequency of intrapartum fetal ECG tracings with ST-events is similar among SGA, AGA, and LGA fetuses.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1735285","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T22:34:30Z","timestamp":1630449270000},"page":"1465-1471","source":"Crossref","is-referenced-by-count":0,"title":["Intrapartum Fetal Electrocardiogram in Small- and Large-for-Gestational Age Fetuses"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-0102","authenticated-orcid":false,"given":"Lena","family":"Braginsky","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, George Washington University Biostatistics Center, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George R.","family":"Saade","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9455-3973","authenticated-orcid":false,"given":"Michael W.","family":"Varner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean C.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, McGovern Medical School-Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"John M.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan T.N.","family":"Tita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University, New York City, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward K.S.","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwight J.","family":"Rouse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser Y.","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Stanford University, Stanford, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoram","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve N.","family":"Caritis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41372-018-0047-5","article-title":"Risk factors and prognostic significance of altered left ventricular geometry in preterm infants","volume":"38","author":"S Choudhry","year":"2018","journal-title":"J 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Perez-Cruz","year":"2018","journal-title":"Fetal Diagn Ther"},{"issue":"06","key":"ref27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/jmf.11.6.385.390","article-title":"Subclinical myocardial injury in small-for-gestational-age neonates","volume":"11","author":"T Chaiworapongsa","year":"2002","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"07","key":"ref28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1515\/jpm-2014-0305","article-title":"Values of T\/QRS ratio in pregnancies complicated by intrauterine growth restriction","volume":"44","author":"T Fuchs","year":"2016","journal-title":"J Perinat Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2017.00437","article-title":"Evaluation of abdominal fetal electrocardiography in early intrauterine growth restrictionvaluation of abdominal fetal electrocardiography in early intrauterine growth restriction","volume":"8","author":"C L Velayo","year":"2017","journal-title":"Front Physiol"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12884-017-1392-7","article-title":"Evidence of lower oxygen reserves during labour in the growth restricted human foetus: a retrospective study","volume":"17","author":"S Parisi","year":"2017","journal-title":"BMC Pregnancy Childbirth"}],"container-title":["American Journal of 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