{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:11:59Z","timestamp":1768273919591,"version":"3.49.0"},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background\u2003Glioblastoma (GBM) is the most common and aggressive primary brain neoplasia in adults. Seizure is a common manifestation in GBM. Up to 25 to 60% of patients with GBM have seizures. We aim to summarize all the relevant clinical, surgical, radiologic, and molecular features of a cohort of patients suffering from GBM-related epilepsy and measure the outcome, to understand the possible existence of a clinical\/phenotypical specificity of this subgroup of patients.<\/jats:p><jats:p>Methods\u2003We retrospectively analyzed a cohort of 177 patients affected by isocitrate dehydrogenase wild-type (IDH-WT) GBM; 49 patients presented seizure at onset (SaO) and 128 were seizure free (SF). We investigated the relationship between seizures and other prognostic factors of GBMs.<\/jats:p><jats:p>Results\u2003A statistically significant association between the location of the lesions in the parietal lobe and seizures was observed. The left side was more commonly affected. Interestingly, there was a statistical relationship between tumors involving the subventricular zone (SVZ) and SaO patients. The tumors were also smaller on average at diagnosis, and generalized SaOs were associated with longer overall survival.<\/jats:p><jats:p>Conclusions\u2003The typical patient with IDH-WT GBM with SaO is a young (&lt;55 year) male without a history of headache. The lesion is typically small to medium in size and located in the temporoparietal dominant lobe, with a high tendency to involve the SVZ.<\/jats:p>","DOI":"10.1055\/s-0041-1735515","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T23:48:40Z","timestamp":1637279320000},"page":"351-360","source":"Crossref","is-referenced-by-count":13,"title":["IDH Wild-type Glioblastoma Presenting with Seizure: Clinical Specificity, and Oncologic and Surgical Outcomes"],"prefix":"10.1055","volume":"83","author":[{"given":"Alessandro","family":"Pesce","sequence":"additional","affiliation":[{"name":"\u201cSanta Maria Goretti\u201d Hospital, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-5534","authenticated-orcid":false,"given":"Daniele","family":"Armocida","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Human Neurosciences, \u201cSapienza\u201d University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Paglia","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Human Neurosciences, \u201cSapienza\u201d University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Human Neurosciences, \u201cSapienza\u201d University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Frati","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Human Neurosciences, \u201cSapienza\u201d University, Rome, Italy"},{"name":"IRCCS \u201cNeuromed\u201d Pozzilli (IS), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"D'Andrea","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u201cSpaziani\u201d Hospital, Frosinone, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Salvati","sequence":"additional","affiliation":[{"name":"IRCCS \u201cNeuromed\u201d Pozzilli (IS), Italy"},{"name":"Department of Mental and Neurological, Dental and Sensory Organs Health, Tor Vergata University, Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Santoro","sequence":"additional","affiliation":[{"name":"\u201cSanta Maria Goretti\u201d Hospital, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/B978-0-12-802997-8.00005-0","article-title":"Histologic classification of gliomas","volume":"134","author":"A Perry","year":"2016","journal-title":"Handb Clin 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