{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:20:14Z","timestamp":1790281214722,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"04","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glob Med Genet"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite many years of research, radical treatment of Alzheimer's disease (AD) has still not been found. Amyloid-\u03b2 (A\u03b2) peptide is known to play an important role in the pathogenesis of this disease. AD is characterized by three main changes occurring in the central nervous system: (1) A\u03b2 plaque accumulation that prevents synaptic communication, (2) the accumulation of hyperphosphorylated tau proteins that inhibit the transport of molecules inside neurons, and (3) neuronal cell loss of the limbic system. Mechanisms leading to A\u03b2 accumulation in AD are excessive A\u03b2 production as a result of mutations in amyloid precursor protein or genes, and impairment of clearance of A\u03b2 due to changes in A\u03b2 aggregation properties and\/or A\u03b2 removal processes. Human ATP-binding cassette (ABC) transporters are expressed in astrocyte, microglia, neuron, brain capillary endothelial cell, choroid plexus, choroid plexus epithelial cell, and ventricular ependymal cell. ABC transporters have essential detoxification and neuroprotective roles in the brain. The expression and functional changes in ABC transporters contribute to the accumulation of A\u03b2 peptide. In conclusion, the review was aimed to summarize and highlight accumulated evidence in the literature focusing on the changing functions of human ABC transporter members, in AD pathogenesis and progression.<\/jats:p>","DOI":"10.1055\/s-0041-1735541","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T23:21:32Z","timestamp":1631920892000},"page":"149-155","source":"Crossref","is-referenced-by-count":9,"title":["The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease"],"prefix":"10.1016","volume":"08","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-5070","authenticated-orcid":false,"given":"Asli","family":"Aykac","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Near East University, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8075-3672","authenticated-orcid":false,"given":"Ahmet \u00d6zer","family":"Sehirli","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Dentistry, Near East University, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.14336\/AD.2019.0519","article-title":"Alteration in the function and expression of SLC and ABC transporters in the neurovascular unit in Alzheimer's disease and the clinical significance","volume":"11","author":"Y Jia","year":"2020","journal-title":"Aging Dis"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2165\/00002512-200724110-00001","article-title":"Is long-term treatment of Alzheimer's disease with cholinesterase inhibitor therapy justified?","volume":"24","author":"B Seltzer","year":"2007","journal-title":"Drugs Aging"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1021\/cn300077c","article-title":"Role of ABC transporters in the pathogenesis of Alzheimer's disease","volume":"3","author":"A H Abuznait","year":"2012","journal-title":"ACS Chem Neurosci"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1523\/JNEUROSCI.4165-12.2013","article-title":"Deletion of Abca7 increases cerebral amyloid-\u03b2 accumulation in the J20 mouse model of Alzheimer's disease","volume":"33","author":"W S Kim","year":"2013","journal-title":"J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"J Hardy","year":"2002","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fpsyt.2012.00054","article-title":"ABC transporter and the Alzheimer's disease enigma","volume":"3","author":"A Wolf","year":"2012","journal-title":"Front Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.nbd.2014.04.001","article-title":"Alzheimer's and ABC transporters\u2013new opportunities for diagnostics and treatment","volume":"72","author":"J Pahnke","year":"2014","journal-title":"Neurobiol Dis"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1471-4159.2004.02385.x","article-title":"Clearing amyloid through the blood-brain barrier","volume":"89","author":"B V Zlokovic","year":"2004","journal-title":"J Neurochem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0076-6879(98)92011-0","article-title":"Cloning of novel ABC transporter genes","volume":"292","author":"R Allikmets","year":"1998","journal-title":"Methods Enzymol"},{"issue":"07","key":"ref10","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1101\/gr.184901","article-title":"The human ATP-binding cassette (ABC) transporter superfamily","volume":"11","author":"M Dean","year":"2001","journal-title":"Genome Res"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/1479-7364-3-3-281","article-title":"Human ATP-binding cassette (ABC) transporter family","volume":"3","author":"V Vasiliou","year":"2009","journal-title":"Hum Genomics"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2174\/138920111795164020","article-title":"ABC transporters in the CNS - 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