{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:30:14Z","timestamp":1768285814452,"version":"3.49.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"S 02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Inflammatory pseudotumor (IPT) of the skull base is a rare, locally destructive lesion managed with a variety of treatments. We explore the impact of treatment on outcome and assess the prognosis of IPT.<\/jats:p><jats:p>\n          Methods\u2003This is a retrospective review of IPT of the skull base at a tertiary academic medical center. The primary outcome was radiographic progression after treatment. Outcome versus tumor location was also examined and a prognostic model was developed using a logistic regression.<\/jats:p><jats:p>\n          Results\u2003The demographics of 21 patients with IPT are reported. Treatment consisted of corticosteroids (in 80.1% of patients), disease modifying antirheumatic drugs (DMARDs; 33.3%), surgical resection (28.6%), radiation (23.8%), antibiotics (14.3%), chemotherapy (rituximab; 9.5%), and antivirals (4.8%). At 50.7 months, 50.8% had radiographic progression. Local therapy trended toward having a better response than systemic therapy (p\u2009=\u20090.60). IPT of the orbit required 2.4 treatment modalities, compared with 2.0 for pharyngeal IPT, and 1.3 for posterior skull base masses (p\u2009=\u20090.14). A total of 75% orbital IPT underwent radiographic progression, compared with 71% of pharyngeal IPT and 50% of posterior skull base masses (p\u2009=\u20090.62). Sixteen patients were used to create the logistic model of radiographic progression. The Cox\u2013Snell R\n          2 was 0.71 (p\u2009=\u20090.03). No individual variables were statistically significant.<\/jats:p><jats:p>\n          Conclusion\u2003To our knowledge, this is among the largest sample of cases describing the presentation, treatment, and prognosis of IPT of the skull base. Our data suggest that there may be an improved response with local therapy over systemic therapy and better prognosis among posterolateral skull base masses.<\/jats:p>","DOI":"10.1055\/s-0041-1735558","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T23:08:41Z","timestamp":1631315321000},"page":"e555-e563","source":"Crossref","is-referenced-by-count":5,"special_numbering":"S","title":["Treatment and Prognosis of Inflammatory Pseudotumor of the Skull Base"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-9819","authenticated-orcid":false,"given":"Sidney J.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Medical School, University of Michigan Medical School, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany A.","family":"Glazer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin, Madison, Wisconsin, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cher X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Harvard Medical School, Pediatric Otolaryngology, Massachusetts Eye and Ear, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5574-7385","authenticated-orcid":false,"given":"Gregory","family":"Basura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin L.","family":"McKean","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0096-5588(20)32030-4","article-title":"Two interesting benign lung tumors of contradictory histopathology","volume":"9","author":"H Brunn","year":"1939","journal-title":"J Thorac Surg"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1148\/rg.233025073","article-title":"Inflammatory pseudotumor","volume":"23","author":"L D Narla","year":"2003","journal-title":"Radiographics"},{"issue":"01","key":"ref3","first-page":"55","article-title":"Postinflammatory tumors of the lung; report of 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