{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:05:37Z","timestamp":1782320737914,"version":"3.54.5"},"reference-count":36,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Iron deficiency is one of the most common nutritional disorders in the world affecting young females of the reproductive age group. Indeed, an ideal screening test should be capable of identifying iron deficiency long before developing anemia. Henceforth, the present study was aimed to determine utility of hepcidin in iron deficiency and to see its correlation with different iron indices.<\/jats:p><jats:p>\n          Methods\u2003This cross-sectional study was conducted in the Department of Biochemistry, SGT Medical College Hospital and Research Institute, Budhera, Gurugram, Haryana, India. It included 200 nonpregnant female students aged between 18 and 25 years. Estimation of hepcidin was by enzyme-linked immunosorbent assay. Quantitative estimation of serum iron, total iron-binding capacity (TIBC), and transferrin saturation was done via semi-autoanalyzer. Statistical analysis was done using SPSS v22.<\/jats:p><jats:p>\n          Results\u2003The reference range of urinary hepcidin established in this study was 110 to 969 ng\/mg creatinine (mean\u2009\u00b1\u2009standard deviation 328.3\u2009\u00b1\u2009195.07 ng\/mg creatinine). Serum hepcidin and urinary hepcidin had a significant correlation with iron indices. Area under the curve of urinary hepcidin was obtained with best combination of diagnostic sensitivity (82.6%) and specificity (83.1%) at a cutoff value of\u2009&gt;\u200915.7 ng\/mL and \u2264 199 ng\/mg, respectively.<\/jats:p><jats:p>\n          Conclusion\u2003Since ferritin, TIBC, transferrin saturation, and hepcidin each represent different aspects of iron metabolism, incorporating hepcidin in the present diagnostics and combined evaluation of these indices may accord enhanced clinical information. Hepcidin would help to stratify the vulnerable young healthy female population in early stages of iron deficiency and guide proper interventions to reduce morbidity.<\/jats:p>","DOI":"10.1055\/s-0041-1735585","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T01:26:32Z","timestamp":1632360392000},"page":"175-182","source":"Crossref","is-referenced-by-count":2,"title":["Role of Serum and Urinary Hepcidin in Young Females of Reproductive Age in North India"],"prefix":"10.25259","volume":"14","author":[{"given":"Shaveta","family":"Laller","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, SGT Medical College and Hospital, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, ESIC Medical College, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Haldar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Academic Block, Vardhman Mahavir Medical College (VMMC and SJH), Ansari Nagar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"ref1","volume-title":"World-Wide Prevalence of Anaemia, 1993 to 2005","author":"World Health Organization","year":"2008"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.5045\/kjh.2012.47.4.286","article-title":"Serum hepcidin levels and iron parameters in children with iron deficiency","volume":"47","author":"H S Choi","year":"2012","journal-title":"Korean J Hematol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0140-6736(07)61235-5","article-title":"Nutritional iron deficiency","volume":"370","author":"M B Zimmermann","year":"2007","journal-title":"Lancet"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1373\/clinchem.2009.140053","article-title":"Hepcidin in human iron disorders: diagnostic implications","volume":"57","author":"J J Kroot","year":"2011","journal-title":"Clin Chem"},{"issue":"09","key":"ref6","first-page":"1434","article-title":"Hepcidin and iron homeostasis. Biochimica et Biophysica Acta (BBA)-","volume":"1823","author":"T Ganz","year":"2012","journal-title":"Molecular Cell Research."},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood-2003-03-0672","article-title":"Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation","volume":"102","author":"T Ganz","year":"2003","journal-title":"Blood"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3324\/haematol.11705","article-title":"Hepcidin: from discovery to differential diagnosis","volume":"93","author":"E H Kemna","year":"2008","journal-title":"Haematologica"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"E Nemeth","year":"2004","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000243791","article-title":"The role of hepcidin in iron metabolism","volume":"122","author":"E Nemeth","year":"2009","journal-title":"Acta Haematol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","article-title":"Hepcidin and iron regulation, 10 years later","volume":"117","author":"T Ganz","year":"2011","journal-title":"Blood"},{"key":"ref12","first-page":"844","volume-title":"Iron Deficiency and other hypoproliferative anaemias","author":"J W Adamson","year":"2012","edition":"18th ed."},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.beha.2004.08.022","article-title":"Diagnosis and management of iron-deficiency anaemia","volume":"18","author":"J D Cook","year":"2005","journal-title":"Best Pract Res Clin Haematol"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"G199","DOI":"10.1152\/ajpgi.00412.2005","article-title":"Iron imports. IV. Hepcidin and regulation of body iron metabolism","volume":"290","author":"T Ganz","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bcmd.2007.07.009","article-title":"Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin","volume":"40","author":"E V Valore","year":"2008","journal-title":"Blood Cells Mol Dis"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1074\/jbc.M008922200","article-title":"Hepcidin, a urinary antimicrobial peptide synthesized in the liver","volume":"276","author":"C H Park","year":"2001","journal-title":"J Biol Chem"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1182\/blood-2008-02-139915","article-title":"Immunoassay for human serum hepcidin","volume":"112","author":"T Ganz","year":"2008","journal-title":"Blood"},{"issue":"37","key":"ref18","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.3748\/wjg.15.4617","article-title":"An update on iron physiology","volume":"15","author":"M Mu\u00f1oz","year":"2009","journal-title":"World J Gastroenterol"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.critrevonc.2007.06.006","article-title":"Pathophysiology of anemia and erythrocytosis","volume":"64","author":"V M Hodges","year":"2007","journal-title":"Crit Rev Oncol Hematol"},{"issue":"25","key":"ref20","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1182\/blood-2011-02-337907","article-title":"Serum hepcidin: reference ranges and biochemical correlates in the general population","volume":"117","author":"T E Galesloot","year":"2011","journal-title":"Blood"},{"issue":"25","key":"ref21","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1182\/blood-2011-02-337907","article-title":"Serum hepcidin: reference ranges and biochemical correlates in the general population","volume":"117","author":"T E Galesloot","year":"2011","journal-title":"Blood"},{"issue":"07","key":"ref22","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1172\/JCI32701","article-title":"Hepcidin regulation: ironing out the details","volume":"117","author":"I De Domenico","year":"2007","journal-title":"J Clin Invest"},{"issue":"01","key":"ref23","first-page":"14","article-title":"Study of serum iron, TIBC, transferrin saturation and ferritin in iron deficiency anaemia in tertiary care hospital","volume":"3","author":"A Veena","year":"2013","journal-title":"IJPBS"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2796.1989.tb01408.x","article-title":"Iron deficiency: definition and diagnosis","volume":"226","author":"J D Cook","year":"1989","journal-title":"J Intern Med"},{"issue":"06","key":"ref25","first-page":"518","article-title":"Study of iron status in female medical students","volume":"2","author":"S Modi","year":"2013","journal-title":"IJBAMR"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.3390\/nu6115103","article-title":"Micronutrient status in female university students: iron, zinc, copper, selenium, vitamin B12 and folate","volume":"6","author":"F Fayet-Moore","year":"2014","journal-title":"Nutrients"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.18203\/2320-6012.ijrms20204245","article-title":"Study the role of hepcidin in diagnosis of iron deficiency anemia in young females of northern India","volume":"8","author":"S K Bansal","year":"2020","journal-title":"Int J Res Med Sci."},{"issue":"08","key":"ref29","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3324\/haematol.2010.037960","article-title":"Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors","volume":"96","author":"S R Pasricha","year":"2011","journal-title":"Haematologica"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5348\/ijbti-2017-28-OA-1","article-title":"Hepcidin testing; establishing reference values for the Namibian blood donor population","volume":"7","author":"M Gonzo","year":"2017","journal-title":"Int J Blood Transfus Immunohematol."},{"issue":"09","key":"ref31","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/ki.2009.21","article-title":"Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease","volume":"75","author":"D R Ashby","year":"2009","journal-title":"Kidney Int"},{"issue":"03","key":"ref32","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/ndt\/gfp546","article-title":"Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate","volume":"25","author":"H PE Peters","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"02","key":"ref33","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3945\/ajcn.2008.26589","article-title":"Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women","volume":"89","author":"M F Young","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"03","key":"ref34","first-page":"451","article-title":"Hepcidin and iron status among pregnant women in Bangladesh","volume":"17","author":"K J Schulze","year":"2008","journal-title":"Asia Pac J Clin Nutr"},{"issue":"02","key":"ref35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/ejh.ejh_9_19","article-title":"Urinary hepcidin concentration in assessment of iron homeostasis in pediatrics","volume":"44","author":"S G Al Sharkawy","year":"2019","journal-title":"The Egyptian Journal of Haematology."},{"issue":"01","key":"ref36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1824-7288-37-37","article-title":"Urinary hepcidin level as an early predictor of iron deficiency in children: a case control study","volume":"37","author":"M Sanad","year":"2011","journal-title":"Ital J Pediatr"},{"issue":"03","key":"ref37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/JMISR.JMISR_52_18","article-title":"The role of urinary hepcidin in early detection of iron deficiency anemia","volume":"1","author":"H Mouhamed","year":"2018","journal-title":"Journal of Medicine in Scientific Research."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3923\/ajcn.2015.9.16","article-title":"Urinary hepcidin in diagnosis of iron deficiency anemia","volume":"7","author":"M M Al-Mazahi","year":"2015","journal-title":"Asian J Clin Nutr"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1735585.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:19:48Z","timestamp":1703405988000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/role-of-serum-and-urinary-hepcidin-in-young-females-of-reproductive-age-in-north-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":36,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,8,16]]},"published-print":{"date-parts":[[2022,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1735585","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,22]]}}}