{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:14:02Z","timestamp":1793934842159,"version":"4.8.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Objective\u2003Describe the association between cardiac dysfunction and death or moderate-to-severe abnormalities on brain magnetic resonance imaging (MRI) in neonates undergoing therapeutic hypothermia for hypoxic ischemic encephalopathy (HIE).<\/jats:p>\n                  <jats:p>Study Design\u2003Retrospective study in neonates with moderate or severe HIE undergoing therapeutic hypothermia between 2008 and 2017. Primary outcome was death or moderate-to-severe brain injury using the Barkovich score. Conventional and speckle-tracking echocardiography measures were extracted from available echocardiograms to quantify right (RV) and left (LV) ventricular functions.<\/jats:p>\n                  <jats:p>Results\u2003A total of 166 newborns underwent therapeutic hypothermia of which 53 (36.5%) had echocardiography performed. Ten (19%) died prior to hospital discharge, and 11 (26%) had moderate-to-severe brain injury. There was no difference in chronologic age at echocardiography between the normal and adverse outcome groups (22 [\u00b119] vs. 28 [\u00b121] hours, p\u2009=\u20090.35). Cardiac findings in newborns with abnormal outcome included lower systolic and diastolic blood pressure (BP) at echocardiography (p\u2009=\u20090.004) and decreased tricuspid annular plane systolic excursion (a marker of RV systolic function; p\u2009=\u20090.01), while the ratio of systolic pulmonary artery (PA) pressure to systolic BP indicated isosystemic pressures (&gt;2\/3 systemic) in both groups. A multilogistic regression analysis, adjusting for weight and seizure status, indicated an association between abnormal outcome and LV function by longitudinal strain, as well as by ejection fraction.<\/jats:p>\n                  <jats:p>Conclusion\u2003Newborns who died or had moderate\u2013to-severe brain injury had a higher incidence of cardiac dysfunction but similar PA pressures when compared with those who survived with mild or no MRI abnormalities.<\/jats:p>\n                  <jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0041-1735618","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T18:48:40Z","timestamp":1631040520000},"page":"1336-1344","source":"Crossref","is-referenced-by-count":16,"title":["Cardiac Dysfunction in Neonatal HIE Is Associated with Increased Mortality and Brain Injury by MRI"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-0964","authenticated-orcid":false,"given":"Gabriel","family":"Altit","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Center, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia L.","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital Stanford, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina V.","family":"Guimaraes","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology, Lucile Packard Children's Hospital Stanford, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Bhombal","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital Stanford, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Sivakumar","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine Stanford University, Lucile Packard Children's Hospital, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital Stanford, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Chock","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital Stanford, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisa V.","family":"Meurs","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital Stanford, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"ref1","first-page":"H100","article-title":"Effects of cord compression on fetal blood flow distribution and O2 delivery","volume":"252","author":"J Itskovitz","year":"1987","journal-title":"Am J 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