{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:13:29Z","timestamp":1793121209699,"version":"4.5.0"},"reference-count":91,"publisher":"Georg Thieme Verlag KG","issue":"05\/06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Reprod Med"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Androgen priming with either dehydroepiandrosterone (DHEA) or testosterone has been suggested as an adjunct to improve in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). Numerous studies have investigated the effects of both DHEA and testosterone on IVF outcome. The results were inconsistent, and the quality of most studies is substandard. Meta-analyses have consistently reported that DHEA does appear to significantly improve IVF outcome in women with predicted or proven poor ovarian response (POR), but these have included some normal responders and\/or nonrandomized studies. Our meta-analyses including randomized controlled trials (RCTs) incorporating only women with DOR or POR suggest that DHEA confers no benefit. While meta-analyses of RCTs on the use of testosterone in women with DOR or POR showed an improved IVF outcome, most studies included are of low quality with high risk of bias. When analysis of data from studies of only low-risk bias was performed, such a benefit with testosterone was not observed. Although recruitment may well be a challenge, a large, well-designed RCT is, however, still warranted to investigate whether or not androgen priming with either DHEA or testosterone should be recommended as an adjuvant treatment for women with DOR or POR undergoing IVF.<\/jats:p>","DOI":"10.1055\/s-0041-1735646","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T22:39:40Z","timestamp":1631227180000},"page":"207-219","source":"Crossref","is-referenced-by-count":5,"title":["The Use of Androgen Priming in Women with Reduced Ovarian Reserve Undergoing Assisted Reproductive Technology"],"prefix":"10.1055","volume":"39","author":[{"given":"Alison","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Surgery, University Hospitals of Leicester NHS Trust, Leicester Fertility Centre, Infirmary Square, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-9376","authenticated-orcid":false,"given":"Kanna","family":"Jayaprakasan","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Surgery, University Hospitals of Derby and Burton NHS Foundation Trust, Royal Derby Hospital, Derby, United Kingdom"},{"name":"CARE Fertility Nottingham, Nottingham Business Park, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1093\/humrep\/deh285","article-title":"Ovarian reserve and reproductive age may be determined from measurement of ovarian volume by transvaginal sonography","volume":"19","author":"W H Wallace","year":"2004","journal-title":"Hum Reprod"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1098\/rspb.1963.0055","article-title":"A quantitative and cytological study of germ cells in human ovaries","volume":"158","author":"T G Baker","year":"1963","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000140595","article-title":"Quantitative morphological investigations of the follicular system in women; variations at different ages","volume":"14","author":"E Block","year":"1952","journal-title":"Acta Anat (Basel)"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1210\/jcem-65-6-1231","article-title":"Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion","volume":"65","author":"S J Richardson","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1093\/oxfordjournals.humrep.a019422","article-title":"A model conforming the decline in follicle numbers to the age of menopause in women","volume":"11","author":"M J Faddy","year":"1996","journal-title":"Hum Reprod"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/humupd\/dmi006","article-title":"Fertility and ageing","volume":"11","author":"D T Baird","year":"2005","journal-title":"Hum Reprod Update"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0015-0282(16)60854-3","article-title":"Effect of maternal age and number of in vitro fertilization procedures on pregnancy outcome","volume":"52","author":"S L Padilla","year":"1989","journal-title":"Fertil Steril"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fendo.2019.00094","article-title":"Advanced maternal age in IVF: still a challenge? 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