{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:42Z","timestamp":1740126822250,"version":"3.37.3"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"13","funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"crossref","award":["PICT-2018-4275 (PI: L\u00f3pez Camelo JS)"],"award-info":[{"award-number":["PICT-2018-4275 (PI: L\u00f3pez Camelo JS)"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"crossref","award":["PICT-2018-4285 (PI: Lucas G. Gimenez)"],"award-info":[{"award-number":["PICT-2018-4285 (PI: Lucas G. Gimenez)"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to describe lethality of birth defects (BDs) in newborns categorized by gestational age and birth weight and to identify BDs associated with prematurity.<\/jats:p><jats:p>\n            Study Design\u2003Live born infants (n\u2009=\u200916,452) with isolated BDs classified by severity, and 42,511 healthy controls were assigned to categories: adequate growth, preterm, or small for gestational age (SGA). Proportion of cases and BDs' lethality rates were obtained by category and compared with controls.<\/jats:p><jats:p>\n            Results\u2003Overall fewer malformed than nonmalformed infants were of adequate growth, while the opposite occurred in the preterm and SGA categories where gastroschisis and esophageal atresia were among the most outstanding defects. For most severe BDs, the early neonatal death rate was higher than control values in all categories; for mild defects, except cleft lip in the preterm category, they did not differ. Diaphragmatic hernia showed the highest lethality values, while those of spina bifida were among the lowest. Talipes, hypospadias, and septal heart defects were mild defects significantly associated with prematurity.<\/jats:p><jats:p>\n            Conclusion\u2003Although reasons, such as induced preterm delivery of fetuses with certain anomalies, could partially account for their high prematurity rates, susceptibility to preterm birth might exist through underlying mechanisms related with the defects. The identification of BDs associated with prematurity should serve to improve measures that prevent preterm birth especially of fetuses at risk.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1735867","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T22:51:21Z","timestamp":1633992681000},"page":"1406-1412","source":"Crossref","is-referenced-by-count":3,"title":["Lethality of Birth Defects in Live Born Infants Categorized by Gestational Age and Birth Weight"],"prefix":"10.1055","volume":"40","author":[{"given":"Monica","family":"Rittler","sequence":"additional","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Gen\u00e9tica, Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"},{"name":"Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC), Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"},{"name":"Secci\u00f3n Gen\u00e9tica M\u00e9dica, Dpto. Neonatolog\u00eda, Hospital Materno Infantil Ram\u00f3n Sard\u00e1, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hebe","family":"Campa\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Gen\u00e9tica, Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"},{"name":"Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC), Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"},{"name":"Comisi\u00f3n de Investigaciones Cient\u00edficas, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvina","family":"Heisecke","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n, Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Ratowiecki","sequence":"additional","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Gen\u00e9tica, Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"},{"name":"Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC), Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Elias","sequence":"additional","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Gen\u00e9tica, Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"},{"name":"Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC), Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Gimenez","sequence":"additional","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Gen\u00e9tica, Centro de Educaci\u00f3n 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Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"},{"name":"Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC), Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas-Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CEMIC-CONICET), Ciudad Aut\u00f3noma de Buenos Aires, Argentina"},{"name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional (INAGEMP), CEMIC-CONICET, Ciudad Aut\u00f3noma de Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/1468-0009.12376","article-title":"Learning From History About Reducing Infant Mortality: Contrasting the Centrality of Structural Interventions to Early 20th-Century Successes in the United States to Their Neglect in Current Global Initiatives","volume":"97","author":"A Bhatia","year":"2019","journal-title":"Milbank Q"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.siny.2017.02.006","article-title":"Early neonatal death: A challenge worldwide","volume":"22","author":"L Lehtonen","year":"2017","journal-title":"Semin Fetal Neonatal Med"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"F22","DOI":"10.1136\/archdischild-2016-311845","article-title":"Estimating Global Burden of Disease due to congenital anomaly: an analysis of European data","volume":"103","author":"B Boyle","year":"2018","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.15585\/mmwr.mm6902a1","article-title":"Infant Mortality Attributable to Birth Defects - United States, 2003-2017","volume":"69","author":"L M 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