{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:22:05Z","timestamp":1775074925970,"version":"3.50.1"},"reference-count":20,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"03","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003The aim of the present retrospective study was to investigate the effectiveness of single-dose gonadotropin releasing hormone (GnRH) antagonist administration, the day after human chorionic gonadotropin (hCG) triggering for final oocyte maturation, on the prevention of premature luteinization in patients with diminished ovarian reserve in in-vitro fertilization (IVF) cycles. The secondary objective of the study was to search the effect of this protocol on pregnancy outcomes.<\/jats:p><jats:p>Methods\u2003This is a retrospective study including 267 infertile patients who have single antral follicle seen with ultrasonography on the 2nd or 3rd day of the menstrual cycle before starting IVF treatment. We randomized patients into two groups. The case group comprised patients who had single-dose GnRH antagonist injection the day after hCG triggering formed, and the patients who had the standard treatment regime formed the control group. In both groups, the oocytes were collected 36\u2009hours after hCG injection.<\/jats:p><jats:p>Results\u2003The premature ovulation rate was significantly low in the case group compared with the control group (6.86 versus 20.6% per scheduled cycle) (p\u2009=\u20090.022). Also, the oocyte retrieval rate (93.14 versus 67.87% per scheduled cycle) (p\u2009=\u20090.013), the oocyte maturity rate (79.42 versus 47.87%) (p\u2009=\u20090.041), the fertilization rate (65.68 versus 34.54%) (p\u2009=\u20090.018), and the embryo transfer rate per scheduled cycle (44.11 versus 18.78%) (p\u2009=\u20090.003) were higher in the GnRH antagonist group than in the control group.<\/jats:p><jats:p>Conclusion\u2003The administration of GnRH antagonist the day after hCG trigger in IVF treatments of patients with diminished ovarian reserve enabled a significant decrease in the rate of premature ovulation but had no effect on live birth rate.<\/jats:p>","DOI":"10.1055\/s-0041-1736297","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T23:53:28Z","timestamp":1644450808000},"page":"245-250","source":"Crossref","is-referenced-by-count":5,"title":["Prevention of Premature Ovulation by Administration of Gonadotropin Releasing Hormone Antagonist the day After Ovulation Triggering in Diminished Ovarian Reserve Patients"],"prefix":"10.61622","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-9405","authenticated-orcid":false,"given":"Bulat Aytek","family":"Sik","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology and Infertility, Sisli Kolan International Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9416-6153","authenticated-orcid":false,"given":"Ozan","family":"Ozolcay","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology and Infertility, Istanbul IVF Centre, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6660-4964","authenticated-orcid":false,"given":"Yilda Arzu","family":"Aba","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Bandirma Onyedi Eyl\u00fcl University, Bal\u0131kesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2895-575X","authenticated-orcid":false,"given":"Alper","family":"Sismanoglu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology and Infertility, Sisli Kolan International Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8750-8955","authenticated-orcid":false,"given":"Sifa","family":"Savas","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology and Infertility, Istanbul IVF Centre, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1311-6278","authenticated-orcid":false,"given":"Serkan","family":"Oral","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology and Infertility, Sisli Kolan International Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/GCO.0000000000000452","article-title":"What is new in the management of poor ovarian response in IVF?","volume":"30","author":"A Vaiarelli","year":"2018","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"02","key":"ref2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/humupd\/8.2.129","article-title":"Efficacy of natural cycle IVF: a review of the literature","volume":"8","author":"M J Pelinck","year":"2002","journal-title":"Hum Reprod Update"},{"issue":"01","key":"ref3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/s0015-0282(00)01638-1","article-title":"Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation","volume":"75","author":"M Fluker","year":"2001","journal-title":"Fertil Steril"},{"key":"ref4","first-page":"4","article-title":"Gonadotrophin-releasing hormone antagonists for assisted reproductive technology","author":"H G Al-Inany","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1093\/humrep\/15.7.1490","article-title":"Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective, safe and convenient: results of a controlled, randomized, multicentre trial. 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