{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:32:10Z","timestamp":1782257530448,"version":"3.54.5"},"reference-count":14,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"12","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003In the present study, we report a case of primary adenoid cystic carcinoma (ACC) of the Bartholin gland with high-grade transformation (HGT). Adenoid cystic carcinoma of the Bartholin gland is a rare tumor and HGT has only been reported in head and neck tumors.<\/jats:p><jats:p>\n          Case Report\u2003A 77-year-old woman with a non-ulcerated vulvar lesion on the topography of the right Bartholin gland. The patient was submitted to tumor resection followed by V\u2013Y island flap and adjuvant radiotherapy. The histopathological examination revealed primary ACC of the Bartholin gland, with areas of HGT and extensive perineural invasion. The immunohistochemical study with p53 showed a diffuse and strong positive reaction in areas with HGT. After 24 months of follow-up, the patient presented distant metastases and died, despite having undergone to chemotherapy.<\/jats:p><jats:p>\n          Conclusion\u2003As far as we know, this case is the first description in the literature of HGT in ACC of the Bartholin gland, and HGT appears to be associated with tumor aggressiveness.<\/jats:p>","DOI":"10.1055\/s-0041-1736301","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T23:32:30Z","timestamp":1640129550000},"page":"980-984","source":"Crossref","is-referenced-by-count":7,"title":["High-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland: Case Report"],"prefix":"10.61622","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4562-3784","authenticated-orcid":false,"given":"Aline Evangelista","family":"Santiago","sequence":"additional","affiliation":[{"name":"Gynecology Department, Universidade Estadual Paulista \u201cJu\u0301lio de Mesquita Filho\u201d, Botucatu, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5036-3702","authenticated-orcid":false,"given":"Nicky","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Gynecology Department, Univeridade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1891-1457","authenticated-orcid":false,"given":"Bernardo Ferreira de Paula","family":"Ricardo","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital MaterDei, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2336-5999","authenticated-orcid":false,"given":"Eduardo Batista","family":"C\u00e2ndido","sequence":"additional","affiliation":[{"name":"Gynecology Department, Univeridade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"},{"name":"Gynecology Department, Hospital MaterDei, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-7232","authenticated-orcid":false,"given":"Rafaela de Souza","family":"Furtado","sequence":"additional","affiliation":[{"name":"Gynecology Department, Univeridade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8486-7861","authenticated-orcid":false,"given":"Agnaldo Lopes da","family":"Silva Filho","sequence":"additional","affiliation":[{"name":"Gynecology Department, Universidade Estadual Paulista \u201cJu\u0301lio de Mesquita Filho\u201d, Botucatu, SP, Brazil"},{"name":"Gynecology Department, Univeridade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"},{"name":"Gynecology Department, Hospital MaterDei, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1136\/jcp.14.3.232","article-title":"Tumours of salivary tissue","volume":"14","author":"J M Cameron","year":"1961","journal-title":"J Clin Pathol"},{"issue":"02","key":"ref2","doi-asserted-by":"publisher","first-page":"300060519863540","DOI":"10.1177\/0300060519863540","article-title":"Adenoid cystic carcinoma of the Bartholin's gland: a case report and literature review","volume":"48","author":"Y Chang","year":"2020","journal-title":"J Int Med Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1784949","DOI":"10.1155\/2019\/1784949","article-title":"Naing k, Jaaback K, Thachil T. 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