{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:48:31Z","timestamp":1790660911482,"version":"4.1.0"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":135,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Radiol Imaging"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leukoencephalopathy, cerebral calcifications, and cysts (LCC) form a very rare association which is named as \u201cLabrune syndrome\u201d after Labrune who reported the first case in 1996. To the best of our knowledge only eight to 10 cases have been reported in literature to date. We report a case of a 26-year-old male with onset of neurological symptoms in late adolescence (at 19 years of age) and presented with complains of continued seizures for 7 years, giddiness with imbalance, and slowly progressive motor symptoms. MRI brain revealed multiple calcifications in bilateral basal ganglia, cerebral white matter, multiple cystic lesions in the supratentorial white matter, and abnormal diffused bilateral white matter T2 hyperintensity suggesting leukoencephalopathy. Histopathological evaluation revealed prominent congested blood vessels suggestive of angiomatous changes and cystic areas suggestive of secondary gliosis.<\/jats:p>","DOI":"10.1055\/s-0041-1736398","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T23:30:34Z","timestamp":1636846234000},"page":"772-775","source":"Crossref","is-referenced-by-count":3,"title":["Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts"],"prefix":"10.1055","volume":"31","author":[{"given":"Anagha R.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Radiology, NMR Scan Centre, Hubli, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita U.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1212\/WNL.46.5.1297","article-title":"Extensive brain calcifications, leukodystrophy, and formation of parenchymal cysts: a new progressive disorder due to diffuse cerebral microangiopathy","volume":"46","author":"P Labrune","year":"1996","journal-title":"Neurology"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1212\/01.WNL.0000119341.59445.CF","article-title":"Leukoencephalopathy, cerebral calcifications, and cysts: new observations","volume":"62","author":"L M Nagae-Poetscher","year":"2004","journal-title":"Neurology"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/088307380101600205","article-title":"Vacuolating megalencephalic leukoencephalopathy in 12 Israeli patients","volume":"16","author":"B Ben-Zeev","year":"2001","journal-title":"J Child Neurol"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/088307389300800205","article-title":"Alexander's disease: clues to diagnosis","volume":"8","author":"C L Pridmore","year":"1993","journal-title":"J Child Neurol"},{"issue":"09","key":"ref5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s002340000363","article-title":"On the pathogenesis of brain tumour cysts: a volumetric study of tumour, oedema and cyst","volume":"42","author":"P N Lohle","year":"2000","journal-title":"Neuroradiology"},{"key":"ref6","first-page":"353","article-title":"Clinical and diagnostic approaches to neurocysticercosis","volume":"54","author":"V Turkulov","year":"2001","journal-title":"Med Pregl"},{"issue":"01","key":"ref7","first-page":"107","article-title":"Central nervous system cryptococcosis: parenchymal calcification and large gelatinous pseudocysts","volume":"18","author":"K S Caldemeyer","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1212\/01.wnl.0000244470.06748.18","article-title":"An adult case of leukoencephalopathy with intracranial calcifications and cysts","volume":"67","author":"J R Corboy","year":"2006","journal-title":"Neurology"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ajmg.a.32080","article-title":"Cerebroretinal microangiopathy with calcifications and cysts (CRMCC)","volume":"146A","author":"T A Briggs","year":"2008","journal-title":"Am J Med Genet A"}],"container-title":["Indian Journal of Radiology and Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1736398.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T23:38:28Z","timestamp":1636846708000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1736398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":9,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2021,11,13]]},"published-print":{"date-parts":[[2021,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1736398","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0971-3026","1998-3808"],"issn-type":[{"value":"0971-3026","type":"print"},{"value":"1998-3808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}