{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T04:34:30Z","timestamp":1771907670183,"version":"3.50.1"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n            Objective\u2003The objective of this study was to determine the degree of progressive posthemorrhagic ventricular dilatation (PHVD) that is associated with a significant decrease in regional cerebral oxygen saturation (rScO2) in premature infants at risk for periventricular\u2013intraventricular hemorrhage (PIVH).<\/jats:p><jats:p>\n            Study Design\u2003Cranial ultrasound (US) and near-infrared spectroscopy (NIRS) measurements of rScO2 were performed on inborn infants with birth weights less than 1,250\u2009g on admission and at 1, 4, and 8 weeks of age. Infants with severe PIVH were studied weekly. A 1-hour average of rScO2 was compared with the frontal\u2013occipital horn ratio (FOHR) measured the same day. Generalized linear models were used to analyze the relationship between FOHR and rScO2, by severity of PIVH, and adjusted for gestational age. Cut-off points of 0.55 for FOHR and 45% for rScO2 were used to calculate odds ratios (OR) and 95% confidence intervals (CI).<\/jats:p><jats:p>\n            Results\u2003The study cohort included 63 infants with normal US, 15 with grade-1 or -2 PIVH (mild group), and 21 with grade-3 or -4 PIVH (severe group). Increases in FOHR in the severe group were associated with decreases in rScO2 at 1 week (p\u2009=\u20090.036), 4 weeks (p\u2009=\u20090.013), and 8 weeks of life (p\u2009=\u20090.001) compared with the normal and mild groups. Infants with FOHR greater than 0.55 were 92% more likely to have rScO2 less than 45% when compared with infants with FOHR less than 0.55 (OR\u2009=\u20090.08, 95% CI: [0.04, 0.13], p\u2009&lt;\u20090.001).<\/jats:p><jats:p>\n            Conclusion\u2003Progressive PHVD (FOHR\u2009&gt;\u20090.55) is a strong predictor of compromised cerebral oxygenation. A combination of rScO2 and FOHR measurements may aid in identifying infants with PHVD that would benefit from early intervention.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0041-1736533","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T22:42:39Z","timestamp":1634856159000},"page":"1446-1453","source":"Crossref","is-referenced-by-count":6,"title":["Decreased Cerebral Oxygenation in Premature Infants with Progressive Posthemorrhagic Ventricular Dilatation May Help with Timing of Intervention"],"prefix":"10.1055","volume":"40","author":[{"given":"Angelina","family":"June","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Heck","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Neonatal\u2013Perinatal Medicine, Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turaj","family":"Vazifedan","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Thomas","family":"Bass","sequence":"additional","affiliation":[{"name":"Division of Neonatal\u2013Perinatal Medicine, Department of Pediatrics, Eastern Virginia Medical School, Children's Hospital of King's Daughters, Norfolk, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/archdischild-2018-316664","article-title":"Improving incidence trends of severe intraventricular haemorrhages in preterm infants <32 weeks gestation: a cohort study","volume":"105","author":"K T Yeo","year":"2020","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1055\/s-2007-964868","article-title":"Disabilities in children with hydrocephalus\u2013a population-based study of children aged between four and twelve years","volume":"37","author":"E K Persson","year":"2006","journal-title":"Neuropediatrics"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1159\/000452840","article-title":"Cerebrospinal fluid shunting complications in children","volume":"52","author":"B W Hanak","year":"2017","journal-title":"Pediatr Neurosurg"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41372-017-0017-3","article-title":"The use of clinical examination and cranial ultrasound in the diagnosis and management of post-hemorrhagic ventricular dilation in extremely premature infants","volume":"38","author":"R Obeid","year":"2018","journal-title":"J Perinatol"},{"issue":"03","key":"ref5","first-page":"207","article-title":"Posthemorrhagic ventricular dilatation-impact on early neurodevelopmental outcome","volume":"30","author":"P Srinivasakumar","year":"2013","journal-title":"Am J Perinatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fphys.2019.00064","article-title":"The relationship between clinical imaging and neurobehavioral assessment in posthemorrhagic ventricular dilation of prematurity","volume":"10","author":"R A Dorner","year":"2019","journal-title":"Front Physiol"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/s41372-018-0209-5","article-title":"Preterm neuroimaging and neurodevelopmental outcome: a focus on intraventricular hemorrhage, post-hemorrhagic hydrocephalus, and associated brain injury","volume":"38","author":"R A Dorner","year":"2018","journal-title":"J Perinatol"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"e698","DOI":"10.1212\/WNL.0000000000004984","article-title":"Posthemorrhagic ventricular dilatation in preterm infants: When best to intervene?","volume":"90","author":"L M Leijser","year":"2018","journal-title":"Neurology"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1136\/adc.56.12.900","article-title":"Measurement of the growth of the lateral ventricles in preterm infants with real-time ultrasound","volume":"56","author":"M I Levene","year":"1981","journal-title":"Arch Dis Child"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"P28","DOI":"10.1016\/j.jpeds.2020.08.014","article-title":"Randomized controlled early versus late ventricular intervention study (ELVIS) in posthemorrhagic ventricular dilatation: outcome at 2 years","volume":"226","author":"M N Cizmeci","year":"2020","journal-title":"J Pediatr"},{"issue":"08","key":"ref11","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1007\/s00134-009-1486-4","article-title":"Tissue oxygenation index measured using spatially resolved spectroscopy correlates with changes in cerebral blood flow in newborn lambs","volume":"35","author":"F Y Wong","year":"2009","journal-title":"Intensive Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pediatrneurol.2017.05.012","article-title":"Changes in cerebral oxygenation in preterm infants with progressive ventricular dilatation","volume":"73","author":"M Kochan","year":"2017","journal-title":"Pediatr Neurol"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/apa.12942","article-title":"Decompressing posthaemorrhagic ventricular dilatation significantly improves regional cerebral oxygen saturation in preterm infants","volume":"104","author":"F Norooz","year":"2015","journal-title":"Acta Paediatr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pediatrneurol.2019.01.005","article-title":"Cerebral hemodynamics during neonatal cerebrospinal fluid removal","volume":"94","author":"S Bembich","year":"2019","journal-title":"Pediatr Neurol"},{"issue":"05","key":"ref15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000028730","article-title":"Frontal and occipital horn ratio: A linear estimate of ventricular size for multiple imaging modalities in pediatric hydrocephalus","volume":"29","author":"B B O'Hayon","year":"1998","journal-title":"Pediatr Neurosurg"},{"key":"ref16","first-page":"517","volume-title":"Intracranial hemorrhage: germinal matrix-intraventricular hemorrhage","author":"J J Volpe","year":"2008","edition":"5th ed."},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41372-017-0007-5","article-title":"Monitoring cerebral oxygenation of preterm infants using a neonatal specific sensor","volume":"38","author":"M Kenosi","year":"2018","journal-title":"J Perinatol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"g7635","DOI":"10.1136\/bmj.g7635","article-title":"Cerebral near infrared spectroscopy oximetry in extremely preterm infants: phase II randomised clinical trial","volume":"350","author":"S Hyttel-Sorensen","year":"2015","journal-title":"BMJ"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41372-021-00942-w","article-title":"Association between early cerebral oxygenation and neurodevelopmental impairment or death in premature infants","volume":"41","author":"A C Katheria","year":"2021","journal-title":"J Perinatol"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/archdischild-2020-318989","article-title":"School-age outcomes following intraventricular haemorrhage in infants born extremely preterm","volume":"106","author":"N L Hollebrandse","year":"2021","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1736533.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T22:31:55Z","timestamp":1695076315000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1736533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,18]]},"references-count":20,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,9,18]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1736533","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,18]]}}}