{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:18:40Z","timestamp":1754396320510},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type 1 von Willebrand disease (VWD) is the most common subtype of VWD, comprising 75% of VWD patients. We provide a systematic review of type 1 VWD in pregnancy. Our objective was to evaluate the rate of postpartum hemorrhage (PPH) in patients with known type 1 VWD. The primary outcome was rate of PPH. Primary PPH was defined as a cumulative blood loss \u22651,000\u2009mL, or blood loss accompanied by signs and symptoms of hypovolemia within 24\u2009hours postpartum or requiring blood products. Secondary PPH was defined as significant bleeding 24\u2009hours to 12 weeks postpartum. Relevant articles published in English pertaining to VWD and pregnancy were identified without any time or study limitations. Seven articles (n\u2009=\u2009144 pregnancies) met inclusion criteria. The rate of primary PPH was 4\/144 (2.8%). The secondary PPH rate was reported in four studies, and occurred in 7\/48 pregnancies (14.6%), ranging from 2 to 19 days postpartum. In conclusion, according to this systematic review, the frequency of primary PPH in pregnancies with known type 1 VWD is 2.8%. This is similar to the overall PPH rates of 3% reported in the literature. Although the sample size was small, secondary PPH occurred in almost 15% of pregnancies, while in the overall obstetrical population this occurs in approximately 1% of cases. Patients with known type 1 VWD may not be at increased risk of primary PPH, though they appear to bear increased risk of secondary PPH.<\/jats:p>","DOI":"10.1055\/s-0041-1736572","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T23:53:27Z","timestamp":1636415607000},"page":"219-228","source":"Crossref","is-referenced-by-count":4,"title":["Postpartum Hemorrhage in Patients with Type 1 von Willebrand Disease: A Systematic Review"],"prefix":"10.1055","volume":"48","author":[{"given":"Rebecca A.M.","family":"Pierce-Williams","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona M.","family":"Makhamreh","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania"},{"name":"Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Blakey-Cheung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, South Shore University Hospital, Bay Shore, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zimeng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda B.","family":"Al-Kouatly","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel 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