{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:49:14Z","timestamp":1783079354831,"version":"3.54.6"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003The role of surgery in management of sinonasal rhabdomyosarcoma (SNRMS) has traditionally been limited, owing to anatomic and technological challenges and the established role of systemic therapy. Herein, we report our institutional experience with surgical management of SNRMS, with a particular focus on operative approaches, extent and outcomes.<\/jats:p><jats:p>\n          Design\u2003This study is a retrospective cohort study.<\/jats:p><jats:p>\n          Setting\u2003This study was conducted at a single-institution, academic center.<\/jats:p><jats:p>\n          Participants\u2003Patients of any age with histologically confirmed RMS of the nasal cavity, maxillary, ethmoid, frontal, or sphenoid sinus, nasolacrimal duct, or nasopharynx presenting between 1994 and 2020 were included in this study.<\/jats:p><jats:p>\n          Main Outcome Measures\u2003Demographics, tumor characteristics, operative settings, complications and recurrence, and survival outcomes were the primary outcomes of this study.<\/jats:p><jats:p>\n          Results\u2003Our study cohort comprised of 29 patients (mean [range] age: 27.0 [3.1\u201365.7], n\u2009=\u200912 [41%] female). Tumors of the nasal cavity (n\u2009=\u200910, 35%) and ethmoid sinuses (n\u2009=\u200910, 35%) and those with alveolar histology (n\u2009=\u200921, 72%) predominated. Patients who had surgery as part of their treatment (n\u2009=\u200913, 45%) had improved distant metastasis-free survival (DMFS) overall (hazard ratio [HR]: 0.32, 95% CI: 0.11, 0.98, p\u2009=\u20090.05) as compared with those who did not have surgery. Surgical approaches included open (n\u2009=\u20097), endoscopic (n\u2009=\u20094), and combined (n\u2009=\u20092). Eight of these 13 patients (62%) had an R0 resection. Additionally, surgical salvage of recurrent disease was employed in five patients (17%).<\/jats:p><jats:p>\n          Conclusion\u2003SNRMS is an aggressive malignancy with a high rate of recurrence and spread requiring a multidisciplinary approach for optimal outcomes. Our data supports an expanding role for surgery for SNRMS given its feasibility, tolerability, and potential to improve outcomes.<\/jats:p>","DOI":"10.1055\/s-0041-1736590","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T23:52:35Z","timestamp":1636415555000},"page":"350-358","source":"Crossref","is-referenced-by-count":8,"title":["Surgical Management of Rhabdomyosarcoma of the Nasal Cavity and Paranasal Sinuses: Analysis of Operative Indications, Settings, and Outcomes"],"prefix":"10.1055","volume":"83","author":[{"given":"Lulia A.","family":"Kana","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Bellile","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Chugh","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"McKean","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States"},{"name":"Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1177\/0194599811417063","article-title":"Head and neck rhabdomyosarcoma: a critical analysis of population-based incidence and survival data","volume":"145","author":"J H Turner","year":"2011","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/1357714021000066359","article-title":"Surgical principles for children\/adolescents with newly diagnosed rhabdomyosarcoma: a report from the soft tissue sarcoma committee of the children's oncology group","volume":"6","author":"D A Rodeberg","year":"2002","journal-title":"Sarcoma"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/mpo.1259","article-title":"Treatment of children and adolescents with localized parameningeal sarcoma: experience of the Intergroup Rhabdomyosarcoma Study Group protocols IRS-II through -IV, 1978-1997","volume":"38","author":"R B Raney","year":"2002","journal-title":"Med Pediatr Oncol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1001\/archotol.126.4.468","article-title":"Pediatric rhabdomyosarcoma of the head and neck: is there a place for surgical management?","volume":"126","author":"H Daya","year":"2000","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1470-2045(05)01733-X","article-title":"Treatment for childhood rhabdomyosarcoma: the cost of cure","volume":"6","author":"M C Stevens","year":"2005","journal-title":"Lancet Oncol"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11864-006-0028-3","article-title":"Pediatric rhabdomyosarcoma of the head and neck","volume":"7","author":"M B Gillespie","year":"2006","journal-title":"Curr Treat Options Oncol"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/1097-0142(19880115)61:2<209::AID-CNCR2820610202>3.0.CO;2-L","article-title":"The Intergroup Rhabdomyosarcoma Study-I. 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