{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:33:13Z","timestamp":1793493193219,"version":"4.5.0"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>Objective\u2003Hypoxic\u2013ischemic encephalopathy (HIE) is the second cause of neonatal deaths and one of the main conditions responsible for long-term neurological disability. Contrary to past belief, children with mild HIE can also experience long-term neurological sequelae. The aim of this systematic review is to determine the predictive value of long-term neurological outcome of (electroencephalogram) EEG\/amplitude-integrated electroencephalogram (aEEG) in children who complained mild HIE.<\/jats:p>\n                  <jats:p>Study Design\u2003From a first search on PubMed, Google Scholar, and clinicalTrials.gov databases, only five articles were considered suitable for this study review. A statistical meta-analysis with the evaluation of odds ratio was performed on three of these studies.<\/jats:p>\n                  <jats:p>Results\u2003No correlation was found between the characteristics of the electrical activity of the brain obtained through EEG\/aEEG in infants with mild HIE and subsequent neurological involvement.<\/jats:p>\n                  <jats:p>Conclusion\u2003EEG\/aEEG monitoring in infants with mild HIE cannot be considered a useful tool in predicting their neurodevelopmental outcome, and its use for this purpose is reported as barely reliable.<\/jats:p>\n                  <jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0041-1736593","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T19:44:18Z","timestamp":1634672658000},"page":"833-838","source":"Crossref","is-referenced-by-count":6,"title":["Mild Hypoxic\u2013Ischemic Encephalopathy: Can Neurophysiological Monitoring Predict Unfavorable Neurological Outcome? A Systematic Review and Meta-analysis"],"prefix":"10.1055","volume":"40","author":[{"given":"Raffaele","family":"Falsaperla","sequence":"additional","affiliation":[{"name":"Division of Pediatrics and Pediatric Emergency, University Hospital Policlinico \u201cRodolico-San Marco,\u201d Catania, Italy"},{"name":"Division of Neonatal Intensive Care and Neonatology, University Hospital Policlinico \u201cRodolico-San Marco,\u201d Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9365-3075","authenticated-orcid":false,"given":"Sarah","family":"Sciuto","sequence":"additional","affiliation":[{"name":"Division of Pediatrics and Child Neuropsychiatry, Department of Clinical and Experimental Medicine, Pediatrics Postgraduate Residency Program, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Gio\u00e8","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Hospital of Lentini, Lentini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sciuto","sequence":"additional","affiliation":[{"name":"Division of Pediatrics and Child Neuropsychiatry, Department of Clinical and Experimental Medicine, Pediatrics Postgraduate Residency Program, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pisani","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, University Hospital of Children \u201cPietro Barilla,\u201d Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Pavone","sequence":"additional","affiliation":[{"name":"Division of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Division of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.earlhumdev.2018.02.008","article-title":"A review of the conundrum of mild hypoxic-ischemic encephalopathy: Current challenges and moving forward","volume":"120","author":"L Chalak","year":"2018","journal-title":"Early Hum Dev"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. 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