{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:47:43Z","timestamp":1760986063870,"version":"3.37.3"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":75,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg J (N Y)"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Central compartment lymph node dissection (CLND) is a part of the surgical management of differentiated thyroid cancer (DTC). Therapeutic CLND is done to address clinically significant central compartment nodes in patients with DTC, while prophylactic CLND is performed in the presence of high-risk features in the absence of clinically significant neck nodes. Removal of thymus\u2014unilateral or bilateral\u2014during CLND to achieve complete clearance of level VI and VII lymph node stations and address thymic metastasis is debatable.<\/jats:p><jats:p>\n          Objective\u2003The present systematic review was conducted to summarize the evidence, delineating the role of thymectomy during CLND in patients with DTC.<\/jats:p><jats:p>\n          Methods\u2003Electronic databases of PubMed, Embase, and Cochrane were searched from their inception to July 2020 using keywords\u2014thyroid neoplasms or tumors, thyroidectomy, and thymectomy\u2014to identify the articles describing the role of thymectomy during CLND in DTC. A pooled analysis of surgicopathological outcomes was performed using metaprop command in STATA software version 16.<\/jats:p><jats:p>\n          Result\u2003A total of three studies and 347 patients\u2014total thyroidectomy (TT) with bilateral thymectomy in 154, TT with unilateral thymectomy in 166, and TT alone in 27 patients with DTC\u2014were included in the systematic review. The pooled frequency of thymic metastasis was a mere 2% in patients undergoing either unilateral or bilateral thymectomy. The routine addition of thymectomy does not result in better lymph node clearance. Unilateral and bilateral thymectomy were associated with high chances of transient hypocalcemia (12.0% and 56.1%, respectively).<\/jats:p><jats:p>\n          Conclusion\u2003Routine thymectomy is not warranted during CLND, considering minimal oncological benefit and high risk of postoperative hypocalcemia.<\/jats:p>","DOI":"10.1055\/s-0041-1736669","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:35:19Z","timestamp":1639614919000},"page":"e307-e313","source":"Crossref","is-referenced-by-count":4,"title":["Risk Benefit Analysis of Routine Thymectomy for Differentiated Thyroid Cancers: A Systematic Review"],"prefix":"10.1055","volume":"07","author":[{"given":"Pallvi","family":"Kaul","sequence":"additional","affiliation":[{"name":"Department of ENT and Head Neck Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Kaul","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Government Medical College, Jammu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-5012","authenticated-orcid":false,"given":"Dharma Ram","family":"Poonia","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Jakhetiya","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Geetanjali Medical College Hospital, Udaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-4234","authenticated-orcid":false,"given":"Vipin","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of ENT and Head Neck Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9760-5484","authenticated-orcid":false,"given":"Pankaj Kumar","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"F Bray","year":"2018","journal-title":"CA Cancer J 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