{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T19:12:16Z","timestamp":1760987536915,"version":"3.37.3"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antiglutamic acid decarboxylase (GAD65) encephalitis is rare and few pediatric cases have been reported, with variable clinical presentations. A 14-year-old female adolescent was managed in our department. She had been treated for several months for drug-resistant temporal lobe epilepsy and gradually presented major anterograde amnesia with confusion. Upon her arrival at the University Hospital Centre, she showed a classical form of stiff person syndrome. The brain magnetic resonance imaging showed bitemporal hyperintensities and hypertrophy of the amygdala. The blood and cerebrospinal fluid were positive for GAD65 antibodies. At 2 years of immunosuppressive treatment and rehabilitation, the course showed partial improvement of the memory and neuropsychiatric impairment, and epilepsy that continued to be active. GAD65 antibodies are associated with various neurological syndromes, and this presentation combining limbic encephalitis and stiff person syndrome is the first pediatric form published to date; there are also few cases described in adults.<\/jats:p>","DOI":"10.1055\/s-0041-1739134","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:20:36Z","timestamp":1639527636000},"page":"136-139","source":"Crossref","is-referenced-by-count":2,"title":["Stiff Person Syndrome and Encephalitis with GAD Antibodies with Severe Anterograde Amnesia in an Adolescent: A Case Study and Literature Review"],"prefix":"10.1055","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0335-3704","authenticated-orcid":false,"given":"L\u00e9a","family":"Herbulot","sequence":"additional","affiliation":[{"name":"Neuropaediatric Unit, H\u00f4pital des Enfants, CHU Toulouse [Children's Hospital, Toulouse University Hospital], Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00e9","family":"Bost","sequence":"additional","affiliation":[{"name":"Immunology Laboratory, IFB [Federal Institute of Biology], CHU Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Viguier","sequence":"additional","affiliation":[{"name":"Neuropaediatric Unit, H\u00f4pital des Enfants, CHU Toulouse [Children's Hospital, Toulouse University Hospital], Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Faure-Marie","sequence":"additional","affiliation":[{"name":"Referral Center for Language and Learning Disorders, H\u00f4pital des Enfants, CHU Toulouse, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elo\u00efse","family":"Baudou","sequence":"additional","affiliation":[{"name":"Neuropaediatric Unit, H\u00f4pital des Enfants, CHU Toulouse [Children's Hospital, Toulouse University Hospital], Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Cheuret","sequence":"additional","affiliation":[{"name":"Neuropaediatric Unit, H\u00f4pital des Enfants, CHU Toulouse [Children's Hospital, Toulouse University Hospital], Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1474-4422(15)00401-9","article-title":"A clinical approach to diagnosis of autoimmune encephalitis","volume":"15","author":"F Graus","year":"2016","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jaut.2019.04.007","article-title":"The neurological syndromes associated with glutamic acid decarboxylase antibodies","volume":"101","author":"J F 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