{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:09Z","timestamp":1781179089574,"version":"3.54.1"},"reference-count":10,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder that develops from the stem cell compartment. The classical translocation (BCR-ABL1) is present in approximately 95% of CML patients. Through disease progression, clonal evolution with additional chromosomal abnormalities (ACAs) start appearing. Although relatively rare, chromosomal abnormalities can exist or develop in the Philadelphia (Ph)-negative clones, which may lead to the evolution of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). We hereby present a case of AML which emerged from a Ph-negative clone in a patient with a history of CML who was in deep molecular response. The possible mechanisms of ACAs have been discussed.<\/jats:p>","DOI":"10.1055\/s-0041-1739178","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T20:05:09Z","timestamp":1647979509000},"page":"175-177","source":"Crossref","is-referenced-by-count":0,"title":["Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response\u2014An Unusual Case Report"],"prefix":"10.25259","volume":"11","author":[{"given":"Goranthala","family":"Bharathi Devi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9776-6920","authenticated-orcid":false,"given":"Perumal Kalaiyarasi","family":"Jayachandran","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhansi Rani","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Bommannan","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Sundersingh","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood.V65.5.1039.1039","article-title":"Chronic myelogenous leukemia: recent advances","volume":"65","author":"R E Champlin","year":"1985","journal-title":"Blood"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1182\/blood-2013-05-501569","article-title":"European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013","volume":"122","author":"M Baccarani","year":"2013","journal-title":"Blood"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1182\/blood-2007-01-070045","article-title":"Chromosomal abnormalities in Philadelphia chromosome negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase","volume":"110","author":"E Jabbour","year":"2007","journal-title":"Blood"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cdd.2010.106","article-title":"A positive role for c-Abl in Atm and Atr activation in DNA damage response","volume":"18","author":"X Wang","year":"2011","journal-title":"Cell Death Differ"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1182\/blood-2002-07-2053","article-title":"Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority","volume":"101","author":"T Bumm","year":"2003","journal-title":"Blood"},{"issue":"08","key":"ref6","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/sj.leu.2403399","article-title":"Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia","volume":"18","author":"C Terre","year":"2004","journal-title":"Leukemia"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1182\/blood-2006-04-017400","article-title":"Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia","volume":"108","author":"C Kovitz","year":"2006","journal-title":"Blood"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1038\/leu.2014.272","article-title":"Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status","volume":"28","author":"M Schmidt","year":"2014","journal-title":"Leukemia"},{"issue":"07","key":"ref9","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/cncr.22936","article-title":"The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells","volume":"110","author":"M WN Deininger","year":"2007","journal-title":"Cancer"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1182\/blood.V85.12.3636.bloodjournal85123636","article-title":"Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages","volume":"85","author":"R Bhatia","year":"1995","journal-title":"Blood"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1739178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:12:30Z","timestamp":1781176350000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/secondary-acute-myeloid-leukemia-in-a-chronic-myeloid-leukemia-patient-in-deep-molecular-response-an-unusual-case-report\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":10,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,12,2]]},"published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1739178","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,22]]}}}