{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:12Z","timestamp":1781179092573,"version":"3.54.1"},"reference-count":10,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Olfactory neuroblastoma is a rare epithelial malignancy arising from the odorant receptors in the nasal mucosa or along the cribriform plate of the ethmoid bone. Clinical presentation includes nasal stuffiness, local pain, epistaxis, anosmia, visual impairment, proptosis, headache, and seizures. Radiologic imaging with CT or MRI, an ophthalmic evaluation, and histopathologic confirmation with immunohistochemistry are parts of the initial diagnostic workup. Although surgery, chemotherapy, and radiation have an equally important role in the management, earlier stages may preferably be treated with surgery or radiotherapy and the later stages with a multimodality approach.<\/jats:p>\n                  <jats:p>Materials and Methods\u2003We conducted a retrospective review of 13 patients diagnosed with olfactory neuroblastoma, registered at Mehdi Nawaz Jung Regional Cancer Center over a decade (2010\u20132019). We analyzed the age and sex distribution, performance status at presentation, clinical symptomatology, and the Kadish stage. In addition, the therapeutic aspects of patients were studied.<\/jats:p>\n                  <jats:p>Results\u2003The most common presentation noted was nasal stuffiness, followed by epistaxis and proptosis. The majority of patients had good performance status at presentation. Ten patients presented with a Kadish stage C, while the remaining patients presented with Kadish stage B. Cervical nodal metastasis was seen in three patients, four patients received multimodality treatment with neoadjuvant chemoradiotherapy followed by surgery, two patients received neoadjuvant chemotherapy followed by radiation, two patients received only surgery, and one patient received surgery followed by adjuvant radiation. Conformal radiation techniques were used to deliver doses as high as 50 to 66 Gy in 2\u2009Gy per fraction. Two patients presented with distant metastasis during follow-up, one with bone metastasis, and the other with retroperitoneal nodal metastasis; they received palliative chemotherapy and conformal radiation to the primary site.<\/jats:p>\n                  <jats:p>Conclusion\u2003This study concludes that neoadjuvant chemotherapy followed by radiation gives the best outcomes. It has been observed that in multi-modality treatment, radiotherapy played a significant role in improving overall survival and better outcomes. Multidisciplinary discussions provide a better sequencing of management.<\/jats:p>","DOI":"10.1055\/s-0041-1739181","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T21:00:56Z","timestamp":1660683656000},"page":"336-339","source":"Crossref","is-referenced-by-count":2,"title":["Experiences and Outcomes in Olfactory Neuroblastoma Over A Decade at a Tertiary Cancer Center"],"prefix":"10.25259","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-7219","authenticated-orcid":false,"given":"Himabindu","family":"Korra","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, MNJ Institute of Oncology & Regional Cancer Centre, Osmania Medical College, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Benjamin","family":"Gandi","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, MNJ Institute of Oncology & Regional Cancer Centre, Osmania Medical College, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathyusha","family":"Nanuvala","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, MNJ Institute of Oncology & Regional Cancer Centre, Osmania Medical College, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarathi","family":"Ardha","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, MNJ Institute of Oncology & Regional Cancer Centre, Osmania Medical College, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1055\/s-0032-1321512","article-title":"Long-term outcome of esthesioneuroblastoma: hyams grade predicts patient survival","volume":"73","author":"J J Van Gompel","year":"2012","journal-title":"J Neurol Surg B Skull Base"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/1097-0142(197603)37:3<1571::AID-CNCR2820370347>3.0.CO;2-L","article-title":"Olfactory neuroblastoma. A clinical analysis of 17 cases","volume":"37","author":"S Kadish","year":"1976","journal-title":"Cancer"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.amjoto.2015.02.008","article-title":"Multidisciplinary treatment of olfactory neuroblastoma: Patterns of failure and management of recurrence","volume":"36","author":"G J Petruzzelli","year":"2015","journal-title":"Am J Otolaryngol"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1055\/s-0032-1311754","article-title":"Craniofacial surgery for esthesioneuroblastoma: report of an international collaborative study","volume":"73","author":"S G Patel","year":"2012","journal-title":"J Neurol Surg B Skull Base"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijrobp.2015.07.1294","article-title":"Treatment modalities and outcomes of esthesioneuroblastoma in a single institution","volume":"93","author":"Z Yin","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/hed.20127","article-title":"Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center","volume":"27","author":"E M Diaz Jr","year":"2005","journal-title":"Head Neck"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11060-008-9645-y","article-title":"Retrospective review of adjuvant chemotherapy for esthesioneuroblastoma","volume":"90","author":"A B Porter","year":"2008","journal-title":"J Neurooncol"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00405-012-2280-4","article-title":"Survival and failure outcomes in locally advanced esthesioneuroblastoma: a single centre experience of 15 patients","volume":"270","author":"R Kumar","year":"2013","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1748-717X-6-41","article-title":"Improved survival following surgery and radiation therapy for olfactory neuroblastoma: analysis of the SEER database","volume":"6","author":"M E Platek","year":"2011","journal-title":"Radiat Oncol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1227\/NEU.0b013e31827fcdc2","article-title":"Stereotactic radiosurgical salvage treatment for locally recurrent esthesioneuroblastoma","volume":"72","author":"J J Van Gompel","year":"2013","journal-title":"Neurosurgery"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1739181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:12:35Z","timestamp":1781176355000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/experiences-and-outcomes-in-olfactory-neuroblastoma-over-a-decade-at-a-tertiary-cancer-center\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":10,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,2,6]]},"published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1739181","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]}}}