{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:35:15Z","timestamp":1780965315366,"version":"3.54.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Pituitary adenoma coexists with intracranial aneurysms in 2.3 to 3.6% of cases, and intracranial aneurysms are thought to be incidental. On the other hand, older age and cavernous sinus invasion are reported to increase the rate of coexistence, so these two diseases may be related.<\/jats:p><jats:p>\n          Methods\u2003Ten males and 14 females with the coexistence of pituitary adenomas and intracranial aneurysms were retrospectively investigated among 923 patients (2.6%). Patients were subdivided into two groups: those with direct attachment of cerebral aneurysms to the pituitary adenomas and those without direct attachment. The clinical characteristics, therapeutic strategies, and possible effects of vascular remodeling factors were investigated.<\/jats:p><jats:p>\n          Results\u2003Twelve patients had functioning pituitary adenomas, and cavernous sinus invasion was identified in 7 of 24 patients. Five of these 7 patients were treated with priority for the cerebral aneurysm until 2007, whereas 14 of 17 patients without involvement of the aneurysm tip in the tumor were treated with priority for the pituitary adenoma in the later period. Among vascular remodeling factors, strong expression of vascular endothelial growth factor (VEGF) was significantly associated with the coexistence of pituitary adenoma and cerebral aneurysm (p\u2009&lt;\u20090.05).<\/jats:p><jats:p>\n          Conclusion\u2003Intracranial aneurysms were found to coexist in 2.6% of cases of surgically treated pituitary adenomas. VEGF-induced arterial wall remodeling may be part of the mechanism of association between pituitary adenomas and cerebral aneurysms, suggesting possible causative mechanism.<\/jats:p>","DOI":"10.1055\/s-0041-1739232","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T23:37:32Z","timestamp":1640043452000},"page":"555-560","source":"Crossref","is-referenced-by-count":6,"title":["Pituitary Adenomas Associated with Intracranial Aneurysms: the Clinical Characteristics, Therapeutic Strategies, and Possible Effects of Vascular Remodeling Factors"],"prefix":"10.1055","volume":"83","author":[{"given":"Yoshikazu","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kohnan Hospital, Taihaku-ku, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University Hospital, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiji","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/02688697.2018.1429571","article-title":"Neurosurgical image: giant pituitary adenoma and multiple aneurysms","volume":"33","author":"H Agarwal","year":"2019","journal-title":"Br J Neurosurg"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1055\/s-0033-1364166","article-title":"Subarachnoid hemorrhage due to rupture of an intracavernous carotid artery aneurysm coexisting with a prolactinoma under cabergoline treatment","volume":"75","author":"N Akutsu","year":"2014","journal-title":"J Neurol Surg Rep"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s11102-009-0198-7","article-title":"Overview of vascular complications of pituitary surgery with special emphasis on unexpected abnormality","volume":"13","author":"M Berker","year":"2010","journal-title":"Pituitary"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3171\/2011.12.JNS11875","article-title":"Coexistence of intracranial aneurysm in 800 patients with surgically confirmed pituitary adenoma","volume":"116","author":"M C Oh","year":"2012","journal-title":"J Neurosurg"},{"issue":"03","key":"ref5","first-page":"469","article-title":"Pituitary macroadenoma coexistent with a posterior circulation aneurysm leading to subarachnoidal hemorrhage during transsphenoidal surgery","volume":"25","author":"Z Habibi","year":"2015","journal-title":"Turk Neurosurg"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1210\/jc.2010-2721","article-title":"Increased rate of intracranial saccular aneurysms in acromegaly: an MR angiography study and review of the literature","volume":"96","author":"R Manara","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11102-012-0404-x","article-title":"Prevalence of cerebral aneurysm in patients with acromegaly","volume":"16","author":"S Oshino","year":"2013","journal-title":"Pituitary"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.jocn.2011.11.032","article-title":"Expanded endonasal endoscopic approach for resection of a growth hormone-secreting pituitary macroadenoma coexistent with a cavernous carotid artery aneurysm","volume":"19","author":"X Xia","year":"2012","journal-title":"J Clin Neurosci"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3171\/2011.9.JNS11380","article-title":"Cerebral aneurysms with intrasellar extension: a systematic review of clinical, anatomical, and treatment characteristics","volume":"116","author":"B W Hanak","year":"2012","journal-title":"J Neurosurg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.wneu.2016.11.150","article-title":"Clinical features, management considerations and outcomes in case series of patients with parasellar intracranial aneurysms undergoing anterior skull base surgery","volume":"99","author":"D M Raper","year":"2017","journal-title":"World Neurosurg"},{"issue":"07","key":"ref11","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis","volume":"10","author":"M H Vlak","year":"2011","journal-title":"Lancet Neurol"},{"issue":"09","key":"ref12","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1038\/jcbfm.2012.84","article-title":"Biology of intracranial aneurysms: role of inflammation","volume":"32","author":"N Chalouhi","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"E21","DOI":"10.3171\/2019.5.FOCUS19234","article-title":"Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms","volume":"47","author":"J Fr\u00f6sen","year":"2019","journal-title":"Neurosurg Focus"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/0963689718815824","article-title":"Inflammatory smooth muscle cells induced endothelial cell alterations to influence cerebral aneurysm progression via regulation of integrin and VEGF expression","volume":"28","author":"P Liu","year":"2019","journal-title":"Cell Transplant"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3109\/07435800.2013.774411","article-title":"Clinicopathological investigation of vascular endothelial growth factor and von Hippel-Lindau gene-related protein expression in immunohistochemically negative pituitary adenoma: possible involvement in tumor aggressiveness","volume":"38","author":"Y Shimoda","year":"2013","journal-title":"Endocr Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.wneu.2016.10.093","article-title":"Meta-analysis of microarray-based expression profiles to identify differentially expressed genes in intracranial aneurysms","volume":"97","author":"Z Xu","year":"2017","journal-title":"World Neurosurg"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3171\/2019.4.FOCUS19214","article-title":"Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms","volume":"47","author":"X Zhang","year":"2019","journal-title":"Neurosurg Focus"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jnr.22696","article-title":"Changes and function of circulating endothelial progenitor cells in patients with cerebral aneurysm","volume":"89","author":"H Wei","year":"2011","journal-title":"J Neurosci Res"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s10143-005-0411-8","article-title":"VEGF plasma levels in non-ruptured intracranial aneurysms","volume":"29","author":"I E Sandalcioglu","year":"2006","journal-title":"Neurosurg Rev"},{"issue":"26","key":"ref20","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1056\/NEJMoa1113260","article-title":"The natural course of unruptured cerebral aneurysms in a Japanese cohort","volume":"366","author":"A Morita","year":"2012","journal-title":"N Engl J Med"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3171\/2014.9.JNS141088","article-title":"Sellar and parasellar tumor removal without discontinuing antithrombotic therapy","volume":"123","author":"Y Ogawa","year":"2015","journal-title":"J Neurosurg"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0041-1739232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T15:11:52Z","timestamp":1666365112000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0041-1739232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,20]]},"references-count":21,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2022,10,19]]},"published-print":{"date-parts":[[2022,11]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0041-1739232","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,20]]}}}