{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:51Z","timestamp":1740126831867,"version":"3.37.3"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Introduction\u2003The activation of the hypothalamic\u2013pituitary\u2013gonadal axis that occurs in male minipuberty during the first 5 months of life is important for early germ cell development. Orchidopexy during minipuberty may improve fertility potential as the germinative epithelium may benefit from the naturally occurring gonadotropin stimulation. We hypothesize that most boys with congenital nonsyndromic cryptorchidism display normal reproductive hormonal profiles and histological findings during minipuberty.<\/jats:p><jats:p>Methods\u2003We included boys with congenital nonsyndromic cryptorchidism who underwent orchidopexy at less than 160 days of age, having no potential for spontaneous resolution clinically. At surgery, testicular biopsies and reproductive hormones were collected and compared with normal reference values. We measured the germ cells (G\/T) and type A dark spermatogonia number per tubule.<\/jats:p><jats:p>Results\u2003Thirty-five boys aged 37 to 159 (median age: 124) days at orchidopexy were included, five were bilateral. G\/T was below the normal lower range in 26% (9\/35) of the cases. In six of these cases, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were above 97.5 percentile, whereas one case had FSH below 2.5 percentile. Totally, 97% (33\/34, one FSH was missing) exhibited a normal LH\/FSH ratio. LH was more often above 97.5 percentile than FSH: 34% (12\/35) versus 3% (1\/34, p\u2009&lt;\u20090.001). Inhibin B was below 2.5 percentile in 17% (6\/35) of cases who all proved FSH above normal mean and four had LH above normal mean.<\/jats:p><jats:p>Conclusion\u2003Generally, reproductive hormonal profiles of the cryptorchid boys exhibited normal minipubertal pattern. Thus, 26% of the boys had reduced germ cell number, and transient hypogonadotropic hypogonadism could be suspected in few cases.<\/jats:p>","DOI":"10.1055\/s-0041-1739416","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T23:51:47Z","timestamp":1638316307000},"page":"026-033","source":"Crossref","is-referenced-by-count":3,"title":["The Majority of Boys Having Orchidopexy for Congenital Nonsyndromic Cryptorchidism during Minipuberty Exhibited Normal Reproductive Hormonal Profiles"],"prefix":"10.1055","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-0625","authenticated-orcid":false,"given":"Simone","family":"Hildorf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea E.","family":"Hildorf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Clasen-Linde","sequence":"additional","affiliation":[{"name":"Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Cortes","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Walther-Larsen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anesthesiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruili","family":"Li","sequence":"additional","affiliation":[{"name":"Douglas Stephens Surgical Research Group, Murdoch Children's Research Institute, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Hutson","sequence":"additional","affiliation":[{"name":"Department of Urology, the Royal Children's Hospital, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorgen","family":"Thorup","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, 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Kolon","year":"2014","journal-title":"J Urol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/JU.0000000000000615","article-title":"Fertility potential is compromised in 20% to 25% of boys with nonsyndromic cryptorchidism despite orchiopexy within the first year of life","volume":"203","author":"S Hildorf","year":"2020","journal-title":"J Urol"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1136\/adc.2008.150219","article-title":"The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort","volume":"94","author":"C L Acerini","year":"2009","journal-title":"Arch Dis Child"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/JU.0000000000001350","article-title":"The fertility potential is impaired in boys with bilateral ascending testes","volume":"205","author":"S Hildorf","year":"2021","journal-title":"J Urol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fendo.2019.00489","article-title":"Postnatal testicular activity in healthy boys and boys with cryptorchidism","volume":"10","author":"T Kuiri-H\u00e4nninen","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1016\/S0022-5347(05)64223-1","article-title":"The ascending testis and the testis undescended since birth share the same histopathology","volume":"168","author":"S L Rusnack","year":"2002","journal-title":"J Urol"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jpedsurg.2016.08.006","article-title":"The diagnostic impact of testicular biopsies for intratubular germ cell neoplasia in cryptorchid boys and the subsequent risk of testicular cancer in men with prepubertal surgery for syndromic or non-syndromic cryptorchidism","volume":"52","author":"L Osterballe","year":"2017","journal-title":"J Pediatr Surg"},{"issue":"08","key":"ref10","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1210\/jc.2018-00482","article-title":"Sex differences in reproductive hormones during mini-puberty in infants with normal and disordered sex development","volume":"103","author":"T H Johannsen","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"07","key":"ref12","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.fertnstert.2016.09.002","article-title":"Establishing reference values for age-related spermatogonial quantity in prepubertal human testes: a systematic review and meta-analysis","volume":"106","author":"I Masliukaite","year":"2016","journal-title":"Fertil Steril"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.02.012","article-title":"During infancy low levels of follicle-stimulating hormone may result in high rate of germ cell apoptosis","author":"S Hildorf","year":"2021","journal-title":"J Pediatr Surg"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2020.11.007","article-title":"Acquired undescended testis: when does the ascent occur?","author":"L Dinkelbach","year":"2020","journal-title":"J Pediatr Surg"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0022-5347(01)67029-0","article-title":"Quantitative histology of germ cells in the undescended testes of human fetuses, neonates and infants","volume":"154","author":"D Cortes","year":"1995","journal-title":"J Urol"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1699-0463.1998.tb00245.x","article-title":"Cryptorchidism as a caudal developmental field defect. A new description of cryptorchidism associated with malformations and dysplasias of the kidneys, the ureters and the spine from T10 to S5","volume":"106","author":"D Cortes","year":"1998","journal-title":"APMIS"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000497374","article-title":"Sertoli cell number correlates with serum inhibin B in infant cryptorchid boys","volume":"13","author":"S Hildorf","year":"2019","journal-title":"Sex Dev"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1210\/jc.2012-2325","article-title":"Boys with undescended testes: endocrine, volumetric and morphometric studies on testicular function before and after orchidopexy at nine months or three years of age","volume":"97","author":"C Kollin","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/jc.2004-2318","article-title":"Hormonal changes in 3-month-old cryptorchid boys","volume":"91","author":"A M Suomi","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-2001-15484","article-title":"Testicular descent: when to interfere?","volume":"11","author":"A F Hamza","year":"2001","journal-title":"Eur J Pediatr Surg"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0022-3476(80)80477-X","article-title":"Plasma gonadotropin and testosterone values in infants with cryptorchidism","volume":"97","author":"D Gendrel","year":"1980","journal-title":"J Pediatr"},{"issue":"S 02","key":"ref22","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1007\/BF00452857","article-title":"The pituitary-gonadal axis in cryptorchid infants and children","volume":"146","author":"J C Job","year":"1987","journal-title":"Eur J Pediatr"},{"issue":"05","key":"ref23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2605.2008.00877.x","article-title":"The hypothalamus-pituitary-testis axis in boys during the first six months of life: a comparison of cryptorchidism and hypospadias cases with controls","volume":"32","author":"F H Pierik","year":"2009","journal-title":"Int J Androl"},{"issue":"06","key":"ref24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3109\/00365599.2011.609833","article-title":"Bilateral vanished testes diagnosed with a single blood sample showing very high gonadotropins (follicle-stimulating hormone and luteinizing hormone) and very low inhibin B","volume":"45","author":"J Thorup","year":"2011","journal-title":"Scand J Urol Nephrol"},{"issue":"05","key":"ref25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S2213-2600(17)30116-9","article-title":"Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe","volume":"5","author":"W Habre","year":"2017","journal-title":"Lancet Respir Med"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"e0240891","DOI":"10.1371\/journal.pone.0240891","article-title":"Attention deficit hyperactivity disorder and educational level in adolescent and adult individuals after anesthesia and abdominal surgery during infancy","volume":"15","author":"C Arana H\u00e5kanson","year":"2020","journal-title":"PLoS One"},{"issue":"06","key":"ref27","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1460-9592.2000.0531a.x","article-title":"Analgesia following paediatric day-surgical orchidopexy and herniotomy","volume":"10","author":"D Ho","year":"2000","journal-title":"Paediatr 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