{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:56:05Z","timestamp":1782298565674,"version":"3.54.5"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["NNF SA170030576"],"award-info":[{"award-number":["NNF SA170030576"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim\u2003Congenital monorchism is considered a condition in which an initially normal testis has existed but subsequently atrophied and disappeared due to a third trimester catastrophe (presumably torsion). Since inhibin B concentrations appear related to Sertoli and germ cells number, we evaluated pre- and postoperative inhibin B of boys with congenital monorchism to determine whether the well-known hypertrophy of the contralateral testis was reflected in inhibin B concentrations.<\/jats:p><jats:p>\n          Materials and Methods\u2003Twenty-seven boys consecutively diagnosed with congenital monorchism (median age 12 months) underwent follow-up with reproductive hormones 1 year postoperatively (median age 25 months). The results were compared with inhibin B of 225 boys with congenital nonsyndromic unilateral cryptorchidism, by converting values to multiple of the median (MoM) for age in normal boys.<\/jats:p><jats:p>\n          Results\u2003Ten boys (37%) had blind-ending vessels and ductus deferens (vanished testis) and the remaining (63%) had testicular remnants. At the time of diagnostic procedure, monorchid boys did not have significantly lower inhibin B (median 114, range 20\u2013208) than unilateral cryptorchid boys (136, 47\u2013393) (p\u2009=\u20090.27). During follow-up, MoM values of inhibin B increased in monorchid boys (median 0.59 to 0.98) and in unilateral cryptorchid boys (0.69 to 0.89) (both p\u2009&lt;\u20090.0001). Compared with the concentration at surgery, an additional 44% monorchid boys had inhibin B MoM values higher than 1.0, whereas only additional 23% of unilateral cryptorchid boys exhibited such values (p\u2009=\u20090.04).<\/jats:p><jats:p>\n          Conclusion\u2003Generally, inhibin B MoM values were normalized during follow-up in boys with congenital monorchism, reflecting compensatory hypertrophy within the first 2.5 years of life. The compensatory capacity to increase was better in monorchism than in unilateral cryptorchidism.<\/jats:p>","DOI":"10.1055\/s-0041-1739417","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T23:51:47Z","timestamp":1638316307000},"page":"034-041","source":"Crossref","is-referenced-by-count":4,"title":["Serial Inhibin B Measurements in Boys with Congenital Monorchism Indicate Compensatory Testicular Hypertrophy in Early Infancy"],"prefix":"10.1055","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-0625","authenticated-orcid":false,"given":"Simone","family":"Hildorf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Clasen-Linde","sequence":"additional","affiliation":[{"name":"Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Cortes","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Fossum","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Pediatric Surgery, Women's and Children's Health, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorgen","family":"Thorup","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4274\/Jcrpe.728","article-title":"Vanishing testes: a literature review","volume":"4","author":"\u00d6 Pirgon","year":"2012","journal-title":"J Clin Res Pediatr Endocrinol"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2559.1991.tb00033.x","article-title":"Testicular regression syndrome\u2013a pathological study of 77 cases","volume":"19","author":"N M 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